SC5b-9 Antibody – Mouse Monoclonal

Mouse anti Human SC5b-9 antibody, clone 3R2/0 recognizes the SC5b-9 complex of around 330 kDa. Both the classical and alternative complement pathways result in the formation of the cytolysis inducing C5b-9 complex. This complex is composed of 190 kDa C5b which is bound to cells via 71 kDa C9. Sublytic assembly of C5b-9 on plasma membranes induces cell cycle activation and survival. The binding of C5b-9 to the 75 kDa S-protein (or vitronectin) in the fluid phase prevents C5b-9 from assembling on the plasma membrane, deactivating it and forming the SC5b-9 complex. SC5b-9 is stable in vitro and is therefore a reliable indicator of terminal complement pathway activation. Removal of Sodium Azide is recommended prior to use in functional assays. MyBioSource recommend the use of EQU003 for this purpose. Mouse anti Human SC5b-9 antibody, clone 3R2/0 has been reprted to work in western blotting applications.

Small volumes of anti-SC5b-9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS212916 is an antibody targeting SC5b-9. Also known as MOUSE ANTI HUMAN SC5b-9. Host: Mouse.