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Interferon Gamma Induced Protein 10kDa (IP10) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2129233

MBS2129233 is an antibody targeting IP10. Also known as HRP Linked Monoclonal Antibody to Interferon Gamma Induced Protein 10kDa (IP10). Reactive in Human. Host: Mouse. More details

$225 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Interferon Gamma Induced Protein 10kDa (IP10), Monoclonal Antibody
Full Product Name
HRP Linked Monoclonal Antibody to Interferon Gamma Induced Protein 10kDa (IP10)
Product Gene Name
anti-IP10 antibody
Product Synonym Names
IP10/Interferon Gamma Induced Protein 10kDa; CXCL10; C7; IFI10; INP10; SCYB10; Crg2; GIP10; Mob1; Chemokine CXC Motif Ligand 10; Small Inducible Cytokine Subfamily B(CysXCys)Member 10
Clonality
Monoclonal
Isotype
IgG1 Kappa
Clone Number
C3
Host
Mouse
Species Reactivity
Human
Form/Format
Liquid; 0.01M PBS, pH7.4, containing 0.05% Proclin300, 50% glycerol.
Purity/Purification
Protein A + Protein G affinity chromatography
Concentration
>=1mg/mL (Please refer to the vial label for the specific concentration.) (lot specific)
Specificity
The antibody is a mouse monoclonal antibody raised against IP10. It has been selected for its ability to recognize IP10 in immunohistochemical staining and western blotting.
Preparation and Storage
Store at 2 degree C to 8 degree C for frequent use, 20 degree C for 24 months
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Matching Pairs
Unconjugated Antibody: IP10 Clone #C3 (MBS2138485)
HRP Conjugated Antibody: IP10 Clone #C3 (MBS2129233)
Molecular Weight
10,881 Da
OMIM
147310
3D Structure
ModBase 3D Structure for P02778
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen Type
Prokaryotic Recombinant proteins/RP
Sequence of Immunogen
Val22~Pro98
Conjugation
HRP

Product Categories/Family for anti-IP10 antibody

Cytokine; Tumor immunity; Infection immunity; Primary, HRP labeled
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-IP10 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
Application Notes for anti-IP10 antibody
WB: 0.52ug/mL
IHC: 520ug/mL
ICC: 520ug/mL

Other Notes

Small volumes of anti-IP10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IP10. It may not necessarily be applicable to this product.

NCBI GI #
149999382
NCBI GeneID
3627
NCBI Accession #
NP_001556.2
UniProt Primary Accession #
P02778
UniProt Secondary Accession #
Q96QJ5
UniProt Related Accession #
P02778
GenBank Nucleotide #
NM_001565.3
NCBI Official Full Name
C-X-C motif chemokine 10
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 10
NCBI Official Symbol
CXCL10
NCBI Official Synonym Symbols
C7; IFI10; INP10; IP-10; crg-2; mob-1; SCYB10; gIP-10
UniProt Protein Name
C-X-C motif chemokine 10
UniProt Synonym Protein Names
10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; Small-inducible cytokine B10
UniProt Gene Name
CXCL10
UniProt Synonym Gene Names
INP10; SCYB10; Gamma-IP10; IP-10
UniProt Entry Name
CXL10_HUMAN
NCBI Protein Information
C-X-C motif chemokine 10; gamma IP10; gamma-IP10; small-inducible cytokine B10; interferon-inducible cytokine IP-10; 10 kDa interferon gamma-induced protein; protein 10 from interferon (gamma)-induced cell line; small inducible cytokine subfamily B (Cys-X

NCBI Summary for IP10

This gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Jul 2008]
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UniProt Comments for IP10

CXCL10: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Chemokine; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region; external side of plasma membrane

Molecular Function: heparin binding; protein binding; CXCR3 chemokine receptor binding; chemokine activity; cAMP-dependent protein kinase regulator activity; receptor binding

Biological Process: muscle development; blood circulation; protein secretion; positive regulation of leukocyte chemotaxis; positive regulation of cAMP metabolic process; chemotaxis; signal transduction; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; cell surface receptor linked signal transduction; response to vitamin D; cell-cell signaling; positive regulation of cell proliferation; response to gamma radiation; positive regulation of transcription from RNA polymerase II promoter; immune response; positive regulation of release of sequestered calcium ion into cytosol; response to cold; inflammatory response; negative regulation of myoblast differentiation; regulation of protein kinase activity; defense response to virus
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Research Articles on IP10

1. Increased CXCL9 serum levels in hepatitis C-related mixed cryoglobulinemia, with autoimmune thyroiditis, associated with high levels of CXCL10.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IP10 antibody

 Reference Product  PubMed Publications
 CXCL9 antibody  >871 publications with IP10 and CXCL9
 CXCR3 antibody  >795 publications with IP10 and CXCR3
 CCL5 antibody  >614 publications with IP10 and CCL5
 CXCL11 antibody  >440 publications with IP10 and CXCL11
 CCR5 antibody  >167 publications with IP10 and CCR5
 CCL20 antibody  >103 publications with IP10 and CCL20
 CCL11 antibody  >97 publications with IP10 and CCL11
 CXCR2 antibody  >48 publications with IP10 and CXCR2
 CCR3 antibody  >47 publications with IP10 and CCR3
 CCR1 antibody  >46 publications with IP10 and CCR1

Pathways associated with anti-IP10 antibody

 Products by Pathway  Pathway Diagram
 CXCR3-mediated Signaling Events Pathway antibodies  CXCR3-mediated Signaling Events Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram

Diseases associated with anti-IP10 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1078 publications with IP10 and Inflammation
 Necrosis Antibodies  >635 publications with IP10 and Necrosis
 Neoplasms Antibodies  >429 publications with IP10 and Neoplasms
 Lung Diseases Antibodies  >308 publications with IP10 and Lung Diseases
 Liver Diseases Antibodies  >203 publications with IP10 and Liver Diseases
 Cardiovascular Diseases Antibodies  >158 publications with IP10 and Cardiovascular Diseases
 Fibrosis Antibodies  >120 publications with IP10 and Fibrosis
 Neoplasms, Experimental Antibodies  >110 publications with IP10 and Neoplasms, Experimental
 Kidney Diseases Antibodies  >80 publications with IP10 and Kidney Diseases
 Lung Injury Antibodies  >60 publications with IP10 and Lung Injury

Organs/Tissues associated with anti-IP10 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1900 publications with IP10 and Blood
 Lung Antibodies  >428 publications with IP10 and Lung
 Liver Antibodies  >249 publications with IP10 and Liver
 Kidney Antibodies  >168 publications with IP10 and Kidney
 Lymph Node Antibodies  >154 publications with IP10 and Lymph Node
 Muscle Antibodies  >113 publications with IP10 and Muscle
 Intestine Antibodies  >87 publications with IP10 and Intestine
 Nerve Antibodies  >57 publications with IP10 and Nerve
 Uterus Antibodies  >30 publications with IP10 and Uterus
 Placenta Antibodies  >24 publications with IP10 and Placenta
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