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Myeloperoxidase (MPO) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2130403

MBS2130403 is an antibody targeting MPO. Also known as APC_Cy7 Linked Polyclonal Antibody to Myeloperoxidase (MPO). Reactive in Rat. Host: Rabbit. More details

$450 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Myeloperoxidase (MPO), Polyclonal Antibody
Full Product Name
APC_Cy7 Linked Polyclonal Antibody to Myeloperoxidase (MPO)
Product Gene Name
anti-MPO antibody
Product Synonym Names
MPO/Myeloperoxidase
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Rat
Form/Format
Liquid; 0.01M PBS, pH7.4, containing 0.05% Proclin300, 50% glycerol.
Purity/Purification
Antigenspecific affinity chromatography followed by Protein A affinity chromatography
Concentration
>=0.1mg/mL (Please refer to the vial label for the specific concentration.) (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against MPO. It has been selected for its ability to recognize MPO in immunohistochemical staining and western blotting.
Preparation and Storage
Store at 2 degree C to 8 degree C for frequent use, 20 degree C for 24 months
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Matching Pairs
Unconjugated Antibody: MPO (MBS2139512)
APC-CY7 Conjugated Antibody: MPO (MBS2130403)
Molecular Weight
51,883 Da
3D Structure
ModBase 3D Structure for D3ZGE2
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen Type
Prokaryotic Recombinant proteins/RP
Sequence of Immunogen
Val252~Thr458
Conjugation
APC Cy7

Product Categories/Family for anti-MPO antibody

Enzyme & Kinase; Infection immunity; Cardiovascular biology; Hepatology; Primary, APC/Cy12368 labeled
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-MPO antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
Application Notes for anti-MPO antibody
WB: 0.52ug/mL
IHC: 520ug/mL
ICC: 520ug/mL

Other Notes

Small volumes of anti-MPO antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MPO. It may not necessarily be applicable to this product.

NCBI GI #
157820285
NCBI GeneID
303413
NCBI Accession #
NP_001100506.1
UniProt Primary Accession #
D3ZGE2
GenBank Nucleotide #
NM_001107036.1
NCBI Official Full Name
myeloperoxidase
NCBI Official Synonym Full Names
myeloperoxidase
NCBI Official Symbol
Mpo
UniProt Protein Name
Myeloperoxidase
UniProt Synonym Protein Names
Myeloperoxidase
Protein Family
Myeloperoxidase
UniProt Gene Name
Mpo
NCBI Protein Information
myeloperoxidase

NCBI Summary for MPO

myeloperoxidase family member that may contribute to hyperoxia-mediated lung injury via nitration of proteins, resulting in reactive nitrogen species [RGD, Feb 2006]

UniProt Comments for MPO

MPO: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Homodimer; disulfide-linked. Each monomer consists of a light and a heavy chain. Belongs to the peroxidase family. XPO subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.11.2.2; Oxidoreductase

Chromosomal Location of Human Ortholog: 10q26

Cellular Component: azurophil granule; cytoplasm; extracellular space; intracellular membrane-bound organelle; mitochondrion; nucleus; secretory granule

Molecular Function: heme binding; heparin binding; peroxidase activity

Biological Process: aging; defense response; defense response to bacterium; defense response to fungus; defense response to Gram-positive bacterium; hydrogen peroxide catabolic process; removal of superoxide radicals; respiratory burst involved in defense response; response to food; response to lipopolysaccharide; response to mechanical stimulus; response to oxidative stress; response to yeast
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Research Articles on MPO

1. Consistent with these in vitro data, in diabetic rat aortas, both MPO expresion and NADPH oxidase activity were increased while the endothelial function was simultaneously impaired. The results suggested that vascular-bound MPO could amplify high glucose-induced vascular injury in diabetes. MPO-NADPH oxidase-HOCl may represent an important pathogenic pathway in diabetic vascular diseases.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-MPO antibody

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