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MYELIN Proteolipid PROTEIN (PLP1) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS213176

Mouse anti myelin proteolipid protein antibody, clone plpc1 recognizes myelin proteolipid protein (PLP) in many mammalian species (Stoffel et al. 1985). Clone plpc1 also recognizes the alternative PLP splice variant lacking part of the cytoplasmic domain… More details

$810 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
MYELIN PROTEOLIPID PROTEIN (PLP1), Monoclonal Antibody
Full Product Name
MOUSE ANTI MYELIN PROTEOLIPID PROTEIN
Product Gene Name
anti-PLP1 antibody
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
plpc1
Host
Mouse
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 1 mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Molecular Weight
26,212 Da
3D Structure
ModBase 3D Structure for P04116
Perservative Stabilisers
0.09% Sodium Azide
Preparation||Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Target Species
Bovine
Applications Tested/Suitable for anti-PLP1 antibody
Immunohistology Frozen, Flow cytometry (FC/FACS), Immunofluorescence (IF), Immunohistology Paraffin, Western Blot (WB)

Testing Data of anti-PLP1 antibody

Published customer image:NLs on MRI and tissue sections stained for PLP and iron. Examples Examples of NLs from tissue MS1 (A, B and C) identified on MRI magnitude (TE = 25.2 ms) and R2* images as well as color-coded PLP-staining and iron staining. Red arrows point towards NLs identified by MRI and confirmed to correspond to area of demyelination by the color-coded PLP staining. Blue arrows point towards NLs identified by the color-coded PLP staining and only retrospectively identified by MRI. Black arrows and black box point towards NLs identified by the color-coded PLP staining and not by MRI even upon a second retrospective image inspection. In the black box we include a large area of demyelination which goes entirely undetected by MRI. In the color-coded PLP staining of figure: green = complete WM demyelination, red = complete GM demyelination, yellow = areas of variably reduced myelin density.From:Yao B, Hametner S, van Gelderen P, Merkle H, Chen C, et al. (2014) 7 Tesla Magnetic Resonance Imaging to Detect Cortical Pathology in Multiple Sclerosis. PLoS ONE 9(10): e108863. doi:10.1371/journal.pone.0108863
Mouse Anti-PLP1 Monoclonal Antibody – Cat# MBS213176

Testing Data of anti-PLP1 antibody

Published customer image: Iron loss in NLs. PLP myelin staining (B) and iron staining (C) on two consecutive slides of tissue MS2 disclose iron loss together with myelin loss in a NL (red arrows). Higher magnification (D, E, F, G) of PLP (D, F) and iron stainings (E, G). In NAGM (D, E), iron is present in oligodendrocytes (black arrow and inset in E) and myelin sheaths. In a NL (F, G), iron is removed from the demyelinated cortical parenchyma and present in perivascular macrophages and microglia (black arrow and inset in G).From:Yao B, Hametner S, van Gelderen P, Merkle H, Chen C, et al. (2014) 7 Tesla Magnetic Resonance Imaging to Detect Cortical Pathology in Multiple Sclerosis. PLoS ONE 9(10): e108863. doi:10.1371/journal.pone.0108863
Mouse Anti-PLP1 Monoclonal Antibody, Testing Data – Cat# MBS213176

Testing Data of anti-PLP1 antibody

Published customer image: NL scheme and PLP staining. (A) Type-I NL with demyelination of the whole width of the cortex (#) and adjacent WM (*). (B) Type-II intracortical lesion evolving around a vessel. (C) Type-III subpial NL. Demyelination spreads from the pial surface until cortical layer 3. Scale bars represent 500 um.From:Yao B, Hametner S, van Gelderen P, Merkle H, Chen C, et al. (2014) 7 Tesla Magnetic Resonance Imaging to Detect Cortical Pathology in Multiple Sclerosis. PLoS ONE 9(10): e108863. doi:10.1371/journal.pone.0108863
Mouse Anti-PLP1 Monoclonal Antibody, Testing Data – Cat# MBS213176

Other Notes

Small volumes of anti-PLP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PLP1 purchase

MBS213176 is an antibody targeting PLP1. Also known as MOUSE ANTI MYELIN PROTEOLIPID PROTEIN. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for PLP1. It may not necessarily be applicable to this product.

NCBI GI #
68299750
NCBI GeneID
281410
NCBI Accession #
NP_776574.2
UniProt Primary Accession #
P04116
UniProt Secondary Accession #
Q3ZBU4; Q9TSH8; A2VDT3
UniProt Related Accession #
P04116
GenBank Nucleotide #
NM_174149.4
NCBI Official Full Name
myelin proteolipid protein
NCBI Official Synonym Full Names
proteolipid protein 1
NCBI Official Symbol
PLP1
NCBI Official Synonym Symbols
PLP
UniProt Protein Name
Myelin proteolipid protein
UniProt Synonym Protein Names
Lipophilin
Protein Family
Patatin-like protein
UniProt Gene Name
PLP1
UniProt Synonym Gene Names
PLP; PLP
UniProt Entry Name
MYPR_BOVIN
NCBI Protein Information
myelin proteolipid protein; lipophilin

UniProt Comments for PLP1

This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-PLP1 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >232 publications with PLP1 and Nervous System Diseases
 Pelizaeus-Merzbacher Disease Antibodies  >156 publications with PLP1 and Pelizaeus-Merzbacher Disease
 Disease Models, Animal Antibodies  >95 publications with PLP1 and Disease Models, Animal
 Nerve Degeneration Antibodies  >25 publications with PLP1 and Nerve Degeneration
 Congenital Abnormalities Antibodies  >19 publications with PLP1 and Congenital Abnormalities
 Inflammation Antibodies  >15 publications with PLP1 and Inflammation
 Nervous System Malformations Antibodies  >14 publications with PLP1 and Nervous System Malformations
 Atrophy Antibodies  >13 publications with PLP1 and Atrophy
 Spastic paraplegia 2, X-linked Antibodies  >12 publications with PLP1 and Spastic paraplegia 2, X-linked
 Abnormalities, Multiple Antibodies  >8 publications with PLP1 and Abnormalities, Multiple

Organs/Tissues associated with anti-PLP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >187 publications with PLP1 and Brain
 Embryonic Tissue Antibodies  >26 publications with PLP1 and Embryonic Tissue
 Liver Antibodies  >7 publications with PLP1 and Liver
 Muscle Antibodies  >6 publications with PLP1 and Muscle
 Kidney Antibodies  >3 publications with PLP1 and Kidney
 Intestine Antibodies  >1 publications with PLP1 and Intestine
 Uncharacterized Tissue Antibodies  >1 publications with PLP1 and Uncharacterized Tissue
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