Mouse Anti-KIF5B Monoclonal Antibody – Cat# MBS213375

KINESIN HEAVY CHAIN (KIF5B) Antibody – Mouse Monoclonal

Name: KIF5B Antibody; Monoclonal; Mouse; Chicken-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS213375
Price: 760 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS213375

MBS213375 recognises the heavy chain of kinesin toward the N-terminus. The epitope is located in the region of amino acids 420-445. Kinesins are microtubule associated motor proteins, responsible for converting nucleoside triphosphate released energy into… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

KINESIN HEAVY CHAIN (KIF5B), Monoclonal Antibody

Full Product Name

MOUSE ANTI KINESIN HEAVY CHAIN

Product Gene Name

anti-KIF5B antibody

Clonality

Monoclonal

Isotype

IgG2b

Clone Number

Host

Mouse

Species Reactivity

Chicken (Expected from Sequence), InVertebrates (Expected from Sequence), Mammals (Expected from Sequence)

Form/Format

Purified
Purified IgG - liquid

Concentration

IgG concentration 1.0 mg/ml (lot specific)

Specificity

This item recognises the heavy chain of kinesin toward the N-terminus. The epitope is located in the region of amino acids 420-445.Kinesins are microtubule associated motor proteins, responsible for converting nucleoside triphosphate released energy into mechanical energy. Kinesin-1 exists as a homodimer of 120-130kDa chains, known as heavy chains. Associated with this dimer when purified from brain homogenates are light chains of 60-70kDa. The light chains are involved in binding of kinesin to organelles and appear to have regulatory functions. They are not essential for motility generation.

Preparation and Storage

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of despatch.

Molecular Weight

109,685 Da

OMIM

602809

3D Structure

ModBase 3D Structure for P33176

Perservative Stabilisers

0.1% Sodium Azide (NaN3)

Immunogen

Bovine brain kinesin
Buffer Solution||Phosphate buffered saline

Target Species

Bovine

Applications Tested/Suitable for anti-KIF5B antibody

Immunohistology Frozen, ELISA (EIA), Immunoblotting (IB), Immunoprecipitation (IP), Immunohistology Paraffin, Western Blot (WB)

Application Notes for anti-KIF5B antibody

Western Blotting: Minimum Dilution: 1/500

Other Notes

Small volumes of anti-KIF5B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KIF5B purchase

MBS213375 is an antibody targeting KIF5B. Also known as MOUSE ANTI KINESIN HEAVY CHAIN. Reactive in Chicken (Expected from Sequence), InVertebrates (Expected from Sequence), Mammals (Expected from Sequence). Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for KIF5B. It may not necessarily be applicable to this product.

NCBI GI #

34083

NCBI GeneID

3799

NCBI Accession #

CAA46703.1

UniProt Primary Accession #

P33176

UniProt Secondary Accession #

Q5VZ85; A0AVB2

UniProt Related Accession #

P33176

NCBI Official Full Name

kinesin heavy chain

NCBI Official Synonym Full Names

kinesin family member 5B

NCBI Official Symbol

KIF5B

NCBI Official Synonym Symbols

KNS; KINH; KNS1; UKHC; HEL-S-61

UniProt Protein Name

Kinesin-1 heavy chain

UniProt Synonym Protein Names

Conventional kinesin heavy chain; Ubiquitous kinesin heavy chain; UKHC

Protein Family

Kinesin

UniProt Gene Name

KIF5B

UniProt Synonym Gene Names

KNS; KNS1; UKHC

UniProt Entry Name

KINH_HUMAN

NCBI Protein Information

kinesin-1 heavy chain; conventional kinesin heavy chain; epididymis secretory protein Li 61; kinesin 1 (110-120kD); ubiquitous kinesin heavy chain

UniProt Comments for KIF5B

KIF5B: Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Belongs to the kinesin-like protein family. Kinesin subfamily.

Protein type: Motor; Microtubule-binding

Chromosomal Location of Human Ortholog: 10p11.22

Cellular Component: ciliary rootlet; microtubule; kinesin complex; neuron projection; membrane; perinuclear region of cytoplasm; endocytic vesicle; cytoplasm; microtubule organizing center; vesicle

Molecular Function: protein binding; plus-end-directed microtubule motor activity; microtubule binding; ATPase activity; microtubule motor activity; ATP binding

Biological Process: axon guidance; regulation of membrane potential; cellular protein metabolic process; positive regulation of potassium ion transport; vesicle transport along microtubule; positive regulation of synaptic transmission, GABAergic; cytoplasm organization and biogenesis; cytoskeleton-dependent intracellular transport; microtubule-based movement

Research Articles on KIF5B

1. nesprin-dependent recruitment of kinesin-1 to the nuclear envelope through the interaction of a conserved LEWD motif with kinesin light chain might be a general mechanism for cell-type-specific nuclear positioning during development.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KIF5B antibody

Reference Product	PubMed Publications
KLC1 antibody	>12 publications with KIF5B and KLC1
KLC2 antibody	>6 publications with KIF5B and KLC2
RANBP2 antibody	>4 publications with KIF5B and RANBP2
VAMP2 antibody	>2 publications with KIF5B and VAMP2
INS antibody	>1 publications with KIF5B and INS
MYO5A antibody	>1 publications with KIF5B and MYO5A
KLC3 antibody	>1 publications with KIF5B and KLC3

Pathways associated with anti-KIF5B antibody

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Dopaminergic Synapse Pathway antibodies	Dopaminergic Synapse Pathway Diagram
Dopaminergic Synapse Pathway antibodies	Dopaminergic Synapse Pathway Diagram
Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies	Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Insulin Signaling Pathway antibodies	Insulin Signaling Pathway Diagram
Insulin Processing Pathway antibodies	Insulin Processing Pathway Diagram
Kinesins Pathway antibodies	Kinesins Pathway Diagram
MHC Class II Antigen Presentation Pathway antibodies	MHC Class II Antigen Presentation Pathway Diagram

Diseases associated with anti-KIF5B antibody

Disease Name	Pubmed Publications
Carcinoma, Non-Small-Cell Lung Antibodies	>22 publications with KIF5B and Carcinoma, Non-Small-Cell Lung
Congenital Abnormalities Antibodies	>3 publications with KIF5B and Congenital Abnormalities
Pain Antibodies	>3 publications with KIF5B and Pain
Inflammation Antibodies	>3 publications with KIF5B and Inflammation
Hypertrophy Antibodies	>2 publications with KIF5B and Hypertrophy
Heart Diseases Antibodies	>2 publications with KIF5B and Heart Diseases
Diabetes Mellitus Antibodies	>2 publications with KIF5B and Diabetes Mellitus
Cognition Disorders Antibodies	>1 publications with KIF5B and Cognition Disorders
Nerve Degeneration Antibodies	>1 publications with KIF5B and Nerve Degeneration
Liver Neoplasms Antibodies	>1 publications with KIF5B and Liver Neoplasms

Organs/Tissues associated with anti-KIF5B antibody

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>51 publications with KIF5B and Lung
Brain Antibodies	>32 publications with KIF5B and Brain
Nerve Antibodies	>21 publications with KIF5B and Nerve
Muscle Antibodies	>15 publications with KIF5B and Muscle
Heart Antibodies	>9 publications with KIF5B and Heart
Blood Antibodies	>8 publications with KIF5B and Blood
Eye Antibodies	>5 publications with KIF5B and Eye
Thyroid Antibodies	>5 publications with KIF5B and Thyroid
Lymph Node Antibodies	>4 publications with KIF5B and Lymph Node
Embryonic Tissue Antibodies	>4 publications with KIF5B and Embryonic Tissue