Mouse Anti-COL8a1 Monoclonal Antibody – Cat# MBS2134838

Collagen Type VIII Alpha 1 (COL8a1) Antibody – Mouse Monoclonal

Name: COL8a1 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS2134838
Price: 485 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2134838

MBS2134838 is an antibody targeting COL8a1. Also known as APC_Cy7 Linked Monoclonal Antibody to Collagen Type VIII Alpha 1 (COL8a1). Reactive in Human. Host: Mouse. More details

$485 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Collagen Type VIII Alpha 1 (COL8a1), Monoclonal Antibody

Full Product Name

APC_Cy7 Linked Monoclonal Antibody to Collagen Type VIII Alpha 1 (COL8a1)

Product Gene Name

anti-COL8a1 antibody

Product Synonym Names

COL8a1/Collagen Type VIII Alpha 1; COL8A1; Collagen Alpha1(VIII)chain; Endothelial collagen; Vastatin

Clonality

Monoclonal

Isotype

IgG2a Kappa

Clone Number

Host

Mouse

Species Reactivity

Human

Form/Format

Liquid; 0.01M PBS, pH7.4, containing 0.05% Proclin300, 50% glycerol.

Purity/Purification

Protein A + Protein G affinity chromatography

Concentration

>=0.1mg/mL (Please refer to the vial label for the specific concentration.) (lot specific)

Specificity

The antibody is a mouse monoclonal antibody raised against COL8a1. It has been selected for its ability to recognize COL8a1 in immunohistochemical staining and western blotting.

Preparation and Storage

Store at 2 degree C to 8 degree C for frequent use, 20 degree C for 24 months
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Matching Pairs

Unconjugated Antibody: COL8a1 Clone #C4 (MBS2139122)
APC-CY7 Conjugated Antibody: COL8a1 Clone #C4 (MBS2134838)

Molecular Weight

73,364 Da

Chromosome Location

Chromosome: 3; NC_000003.11 (99357440..99515577). Location: 3q12.3

OMIM

120251

3D Structure

ModBase 3D Structure for P27658

Supply Chain Verification

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Immunogen Type

Prokaryotic Recombinant proteins/RP

Sequence of Immunogen

Pro575~Pro743

Conjugation

APC Cy7

Product Categories/Family for anti-COL8a1 antibody

Metabolic pathway; Developmental science; Nutrition metabolism; Bone metabolism; Primary, APC/Cy12554 labeled

ISO Certification

Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.

Applications Tested/Suitable for anti-COL8a1 antibody

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Application Notes for anti-COL8a1 antibody

WB: 0.52ug/mL
IHC: 520ug/mL
ICC: 520ug/mL

Other Notes

Small volumes of anti-COL8a1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for COL8a1. It may not necessarily be applicable to this product.

NCBI GI #

32895368

NCBI GeneID

1295

NCBI Accession #

NP_065084.2

UniProt Primary Accession #

P27658

UniProt Secondary Accession #

Q53XI6; Q96D07; D3DN42

UniProt Related Accession #

P27658

GenBank Nucleotide #

NM_020351.3

NCBI Official Full Name

collagen alpha-1(VIII) chain

NCBI Official Synonym Full Names

collagen, type VIII, alpha 1

NCBI Official Symbol

COL8A1

NCBI Official Synonym Symbols

C3orf7

UniProt Protein Name

Collagen alpha-1(VIII) chain

UniProt Synonym Protein Names

Endothelial collagen

Protein Family

Collagen

UniProt Gene Name

COL8A1

UniProt Synonym Gene Names

C3orf7

UniProt Entry Name

CO8A1_HUMAN

NCBI Protein Information

collagen alpha-1(VIII) chain; collagen alpha-1(VIII) chain; endothelial collagen; collagen VIII, alpha-1 polypeptide; cell proliferation-inducing protein 41; smooth muscle cell-expressed and macrophage conditioned medium-induced protein smag-64

NCBI Summary for COL8a1

This gene encodes one of the two alpha chains of type VIII collagen. The gene product is a short chain collagen and a major component of the basement membrane of the corneal endothelium. The type VIII collagen fibril can be either a homo- or a heterotrimer. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Dec 2011]

UniProt Comments for COL8a1

COL8A1: Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis.

Protein type: Extracellular matrix; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 3q12.3

Cellular Component: extracellular matrix; intracellular membrane-bound organelle; endoplasmic reticulum lumen; extracellular region; collagen type VIII

Biological Process: collagen catabolic process; extracellular matrix disassembly; epithelial cell proliferation; extracellular matrix organization and biogenesis; camera-type eye morphogenesis; angiogenesis; cell adhesion

Research Articles on COL8a1

1. The purpose of this study is to evaluate COL8A1 and COL8A2 as candidate genes for thin central corneal thickness in human primary open angle glaucoma patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-COL8a1 antibody

Reference Product	PubMed Publications
COL8A2 antibody	>10 publications with COL8a1 and COL8A2
COL4A1 antibody	>1 publications with COL8a1 and COL4A1
COL12A1 antibody	>1 publications with COL8a1 and COL12A1
COL11A1 antibody	>1 publications with COL8a1 and COL11A1
COL3A1 antibody	>1 publications with COL8a1 and COL3A1
COL1A1 antibody	>1 publications with COL8a1 and COL1A1

Pathways associated with anti-COL8a1 antibody

Products by Pathway	Pathway Diagram
Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies	Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
Collagen Biosynthesis And Modifying Enzymes Pathway antibodies	Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
Collagen Formation Pathway antibodies	Collagen Formation Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram

Diseases associated with anti-COL8a1 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>3 publications with COL8a1 and Neoplasms
Carcinoma Antibodies	>3 publications with COL8a1 and Carcinoma
Kidney Diseases Antibodies	>3 publications with COL8a1 and Kidney Diseases
Fibrosis Antibodies	>2 publications with COL8a1 and Fibrosis
Liver Neoplasms Antibodies	>2 publications with COL8a1 and Liver Neoplasms
Disease Models, Animal Antibodies	>2 publications with COL8a1 and Disease Models, Animal
Liver Diseases Antibodies	>2 publications with COL8a1 and Liver Diseases
Carcinoma, Hepatocellular Antibodies	>2 publications with COL8a1 and Carcinoma, Hepatocellular
Congenital Abnormalities Antibodies	>2 publications with COL8a1 and Congenital Abnormalities
Drug Toxicity Antibodies	>1 publications with COL8a1 and Drug Toxicity

Organs/Tissues associated with anti-COL8a1 antibody

Organ/Tissue Name	Pubmed Publications
Eye Antibodies	>7 publications with COL8a1 and Eye
Kidney Antibodies	>5 publications with COL8a1 and Kidney
Vascular Antibodies	>4 publications with COL8a1 and Vascular
Bone Antibodies	>1 publications with COL8a1 and Bone