• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Thymidine Kinase 1, Soluble (TK1) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2135457

MBS2135457 is an antibody targeting TK1. Also known as PE Linked Monoclonal Antibody to Thymidine Kinase 1, Soluble (TK1). Reactive in Human, Pig. Host: Mouse. More details

$350 / 0.1 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Thymidine Kinase 1, Soluble (TK1), Monoclonal Antibody
Full Product Name
PE Linked Monoclonal Antibody to Thymidine Kinase 1, Soluble (TK1)
Product Gene Name
anti-TK1 antibody
Product Synonym Names
TK1/Thymidine Kinase 1, Soluble; TK2; Thymidine kinase, cytosolic
Clonality
Monoclonal
Isotype
IgG2b Kappa
Clone Number
D2
Host
Mouse
Species Reactivity
Human, Pig
Form/Format
Liquid; 0.01M PBS, pH7.4, containing 0.05% Proclin300, 50% glycerol.
Purity/Purification
Protein A + Protein G affinity chromatography
Concentration
>=0.1mg/mL (Please refer to the vial label for the specific concentration.) (lot specific)
Specificity
The antibody is a mouse monoclonal antibody raised against TK1. It has been selected for its ability to recognize TK1 in immunohistochemical staining and western blotting.
Preparation and Storage
Store at 2 degree C to 8 degree C for frequent use, 20 degree C for 24 months
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Matching Pairs
Unconjugated Antibody: TK1 Clone #D2 (MBS2139189)
PE Conjugated Antibody: TK1 Clone #D2 (MBS2135457)
Molecular Weight
25,469 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (76170160..76183285, complement). Location: 17q23.2-q25.3
OMIM
188300
3D Structure
ModBase 3D Structure for P04183
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen Type
Prokaryotic Recombinant proteins/RP
Conjugation
PE

Product Categories/Family for anti-TK1 antibody

Enzyme & Kinase; Primary, PE labeled
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-TK1 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
Application Notes for anti-TK1 antibody
WB: 0.52ug/mL
IHC: 520ug/mL
ICC: 520ug/mL

Other Notes

Small volumes of anti-TK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TK1. It may not necessarily be applicable to this product.

NCBI GI #
164698438
NCBI GeneID
7083
NCBI Accession #
NP_003249.3
UniProt Primary Accession #
P04183
UniProt Secondary Accession #
Q969V0; Q9UMG9; B2RC58
UniProt Related Accession #
P04183
GenBank Nucleotide #
NM_003258.4
NCBI Official Full Name
thymidine kinase, cytosolic
NCBI Official Synonym Full Names
thymidine kinase 1, soluble
NCBI Official Symbol
TK1
NCBI Official Synonym Symbols
TK2
UniProt Protein Name
Thymidine kinase, cytosolic
Protein Family
Thymidine kinase
UniProt Gene Name
TK1
UniProt Entry Name
KITH_HUMAN
NCBI Protein Information
thymidine kinase, cytosolic; thymidine kinase-1; thymidine kinase 1 soluble isoform

UniProt Comments for TK1

TK: cytosolic thymidine kinase. Phosphorylated during mitosis. Its enzymatic activity is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very low in resting cells.

Protein type: Nucleotide Metabolism - pyrimidine; EC 2.7.1.21; Xenobiotic Metabolism - drug metabolism - other enzymes; Kinase, other

Chromosomal Location of Human Ortholog: 17q23.2-q25.3

Cellular Component: cytosol

Molecular Function: identical protein binding; nucleoside kinase activity; zinc ion binding; thymidine kinase activity; ATP binding

Biological Process: response to nutrient levels; skeletal muscle cell proliferation; nucleobase, nucleoside and nucleotide metabolic process; response to toxin; liver development; fetal process involved in parturition; deoxyribonucleoside monophosphate biosynthetic process; protein homotetramerization; response to cortisol stimulus; pyrimidine base metabolic process; gut development; response to copper ion; nucleotide biosynthetic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; thymidine metabolic process; pyrimidine nucleoside salvage; phosphorylation
Show more

Research Articles on TK1

1. Increased serum level of thymidine kinase 1 correlates with metastatic site in patients with malignant melanoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TK1 antibody

 Reference Product  PubMed Publications
 TP53 antibody  >8 publications with TK1 and TP53
 CDKN1A antibody  >2 publications with TK1 and CDKN1A
 GAPDH antibody  >1 publications with TK1 and GAPDH
 CDK1 antibody  >1 publications with TK1 and CDK1

Pathways associated with anti-TK1 antibody

 Products by Pathway  Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 E2F Transcription Factor Network Pathway antibodies  E2F Transcription Factor Network Pathway Diagram
 Fluoropyrimidine Activity Pathway antibodies  Fluoropyrimidine Activity Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Salvage Reactions Pathway antibodies  Pyrimidine Salvage Reactions Pathway Diagram

Diseases associated with anti-TK1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >142 publications with TK1 and Neoplasms
 Carcinoma Antibodies  >44 publications with TK1 and Carcinoma
 Neoplasms, Experimental Antibodies  >26 publications with TK1 and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >25 publications with TK1 and Breast Neoplasms
 Lung Neoplasms Antibodies  >20 publications with TK1 and Lung Neoplasms
 Drug Toxicity Antibodies  >19 publications with TK1 and Drug Toxicity
 Lung Diseases Antibodies  >17 publications with TK1 and Lung Diseases
 Adenocarcinoma Antibodies  >17 publications with TK1 and Adenocarcinoma
 Disease Models, Animal Antibodies  >12 publications with TK1 and Disease Models, Animal
 Brain Diseases Antibodies  >10 publications with TK1 and Brain Diseases

Organs/Tissues associated with anti-TK1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >96 publications with TK1 and Blood
 Lung Antibodies  >26 publications with TK1 and Lung
 Brain Antibodies  >19 publications with TK1 and Brain
 Liver Antibodies  >17 publications with TK1 and Liver
 Lymph Antibodies  >15 publications with TK1 and Lymph
 Lymph Node Antibodies  >15 publications with TK1 and Lymph Node
 Bone Antibodies  >11 publications with TK1 and Bone
 Muscle Antibodies  >8 publications with TK1 and Muscle
 Bone Marrow Antibodies  >7 publications with TK1 and Bone Marrow
 Kidney Antibodies  >7 publications with TK1 and Kidney
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000