Carcinoembryonic Antigen Related Cell Adhesion Molecule 1 (CEACAM1) Antibody – Mouse Monoclonal

CEACAM1: carcinoembryonic antigen-related cell adhesion molecule 1. A cell-cell adhesion molecule that directly associates with annexin II. Has tumor suppressor activity in prostate carcinoma. Belongs to the immunoglobulin superfamily and the CEA family. Abundantly expressed in epithelia, vessel endothelia, trophoblasts, platelets and neutrophilic granulocytes. Also present in many cell types of the immune system such as B cells, T cells, NK cells, macrophages and dendritic cells. Five alternatively spliced isoforms have been described. Two isoforms are type I membrane proteins, while three are secreted.

Protein type: Membrane protein, integral; Immunoglobulin superfamily; Cell adhesion; Motility/polarity/chemotaxis

Cellular Component: extracellular space; membrane; integral to plasma membrane; brush border membrane; integral to membrane; plasma membrane; external side of plasma membrane

Molecular Function: viral receptor activity; protein homodimerization activity; virion binding; protein kinase binding

Biological Process: Peyer's patch development; negative regulation of JNK cascade; entry of virus into host cell; positive regulation of NFAT protein import into nucleus; positive regulation of JNK cascade; positive regulation of immunoglobulin secretion; signal transduction; calcium-independent cell-cell adhesion; negative regulation of interleukin-2 production; positive regulation of MAP kinase activity; negative regulation of T cell proliferation; negative regulation of cytokine production; calcium-dependent cell-cell adhesion; positive regulation of T cell proliferation; homophilic cell adhesion; cell adhesion