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Glutamate Receptor, Ionotropic, Nmethyldaspartate 2d (GRIN2D) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2136662

MBS2136662 is an antibody targeting GRIN2D. Also known as Biotin Linked Monoclonal Antibody to Glutamate Receptor, Ionotropic, NMethylDAspartate 2D (GRIN2D). Reactive in Human. Host: Mouse. More details

$235 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Glutamate Receptor, Ionotropic, NMethylDAspartate 2D (GRIN2D), Monoclonal Antibody
Full Product Name
Biotin Linked Monoclonal Antibody to Glutamate Receptor, Ionotropic, NMethylDAspartate 2D (GRIN2D)
Product Gene Name
anti-GRIN2D antibody
Product Synonym Names
GRIN2D/Glutamate Receptor, Ionotropic, NMethylDAspartate 2D; EB11; NMDAR2D; NR2D; NMethyldAspartate Receptor Subunit 2D; Glutamate [NMDA] receptor subunit epsilon4
Clonality
Monoclonal
Isotype
IgG1 Kappa
Clone Number
D5
Host
Mouse
Species Reactivity
Human
Form/Format
Liquid; 0.01M PBS, pH7.4, containing 0.05% Proclin300, 50% glycerol.
Purity/Purification
Protein A + Protein G affinity chromatography
Concentration
>=1mg/mL (Please refer to the vial label for the specific concentration.) (lot specific)
Specificity
The antibody is a mouse monoclonal antibody raised against GRIN2D. It has been selected for its ability to recognize GRIN2D in immunohistochemical staining and western blotting.
Preparation and Storage
Store at 2 degree C to 8 degree C for frequent use, 20 degree C for 24 months
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Matching Pairs
Unconjugated Antibody: GRIN2D Clone #D5 (MBS2139305)
Biotin Conjugated Antibody: GRIN2D Clone #D5 (MBS2136662)
Molecular Weight
143,752 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (48898132..48948188). Location: 19q13.33
OMIM
602717
3D Structure
ModBase 3D Structure for O15399
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen Type
Prokaryotic Recombinant proteins/RP
Sequence of Immunogen
Phe28~Ala584
Conjugation
Biotin

Product Categories/Family for anti-GRIN2D antibody

Neuro science; Primary, Biotin labeled
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-GRIN2D antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
Application Notes for anti-GRIN2D antibody
WB: 0.52ug/mL
IHC: 520ug/mL
ICC: 520ug/mL

Other Notes

Small volumes of anti-GRIN2D antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GRIN2D. It may not necessarily be applicable to this product.

NCBI GI #
153946391
NCBI GeneID
2906
NCBI Accession #
NP_000827.2
UniProt Primary Accession #
O15399
UniProt Related Accession #
O15399
GenBank Nucleotide #
NM_000836.2
NCBI Official Full Name
glutamate receptor ionotropic, NMDA 2D
NCBI Official Synonym Full Names
glutamate receptor, ionotropic, N-methyl D-aspartate 2D
NCBI Official Symbol
GRIN2D
NCBI Official Synonym Symbols
EB11; NR2D; GluN2D; NMDAR2D
UniProt Protein Name
Glutamate receptor ionotropic, NMDA 2D
UniProt Synonym Protein Names
EB11; Glutamate [NMDA] receptor subunit epsilon-4; N-methyl D-aspartate receptor subtype 2D
Protein Family
Glutamate receptor ionotropic
UniProt Gene Name
GRIN2D
UniProt Synonym Gene Names
GluN2D; NMDAR2D; GluN2D; NMDAR2D; NR2D
UniProt Entry Name
NMDE4_HUMAN
NCBI Protein Information
glutamate receptor ionotropic, NMDA 2D; estrogen receptor binding CpG island; N-methyl D-aspartate receptor subtype 2D; N-methyl-d-aspartate receptor subunit 2D; glutamate [NMDA] receptor subunit epsilon-4

NCBI Summary for GRIN2D

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). [provided by RefSeq, Mar 2010]
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UniProt Comments for GRIN2D

NMDAR2D: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2D/GRIN2D subfamily.

Protein type: Membrane protein, multi-pass; Channel, ligand-gated; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: postsynaptic membrane; dendrite; plasma membrane; cell junction; N-methyl-D-aspartate selective glutamate receptor complex

Molecular Function: protein binding; extracellular-glutamate-gated ion channel activity; N-methyl-D-aspartate selective glutamate receptor activity

Biological Process: synaptic transmission; synaptic transmission, glutamatergic; startle response; adult locomotory behavior; ionotropic glutamate receptor signaling pathway; regulation of sensory perception of pain; signal transduction
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Research Articles on GRIN2D

1. Absence of truncating mutation in GRIN1 and GRIN2D genes in patients with autism spectrum disorder and schizophrenia and controls.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GRIN2D antibody

 Reference Product  PubMed Publications
 GRIN1 antibody  >5 publications with GRIN2D and GRIN1

Pathways associated with anti-GRIN2D antibody

 Products by Pathway  Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram

Diseases associated with anti-GRIN2D antibody

 Disease Name  Pubmed Publications
 Schizophrenia Antibodies  >6 publications with GRIN2D and Schizophrenia
 Nervous System Diseases Antibodies  >1 publications with GRIN2D and Nervous System Diseases
 Brain Diseases Antibodies  >1 publications with GRIN2D and Brain Diseases
 Seizures Antibodies  >1 publications with GRIN2D and Seizures

Organs/Tissues associated with anti-GRIN2D antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with GRIN2D and Brain
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