CD61 Antibody – Hamster Monoclonal

ITGB3: integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIB/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion

Cellular Component: filopodium membrane; cell surface; focal adhesion; integral to membrane; cell projection; membrane; microvillus membrane; apical plasma membrane; plasma membrane; melanosome; cell junction; integrin complex; nucleus; receptor complex; external side of plasma membrane

Molecular Function: integrin binding; identical protein binding; protein binding; protease binding; extracellular matrix binding; vascular endothelial growth factor receptor 2 binding; fibronectin binding; protein disulfide isomerase activity; receptor activity; cell adhesion molecule binding; peptide binding

Biological Process: negative regulation of lipid transport; entry of virus into host cell; protein folding; positive regulation of osteoclast differentiation; positive regulation of leukocyte migration; positive regulation of smooth muscle cell proliferation; multicellular organismal development; cell-matrix adhesion; smooth muscle cell migration; negative chemotaxis; positive regulation of smooth muscle cell migration; regulation of cell migration; positive regulation of MAPKKK cascade; cell-substrate junction assembly; positive regulation of bone resorption; cell adhesion; cell growth; integrin-mediated signaling pathway; platelet activation; cell migration; negative regulation of lipoprotein metabolic process; positive regulation of cell adhesion mediated by integrin; cell projection morphogenesis; angiogenesis involved in wound healing; regulation of release of sequestered calcium ion into cytosol; cell-substrate adhesion; cellular calcium ion homeostasis; heterotypic cell-cell adhesion; positive regulation of angiogenesis; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of low-density lipoprotein receptor biosynthetic process; positive regulation of osteoblast proliferation; activation of protein kinase activity; positive regulation of endothelial cell proliferation; regulation of G-protein coupled receptor protein signaling pathway; positive regulation of cell migration