CD16/CD32 Antibody – Rat Monoclonal

FCGR2B: a transmembrane receptor for the Fc region of complexed or aggregated immunoglobulin gamma (IgG). Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down modulation of previous state of cell activation triggered via antigen receptors on B cells, T cells or via another Fc receptor. Three splice-variant isoforms have been observed.

Protein type: Membrane protein, integral; Oncoprotein; Cell surface

Cellular Component: recycling endosome; cell surface; cytoskeleton; membrane; integral to plasma membrane; cytoplasm; integral to membrane; extracellular region; plasma membrane; external side of plasma membrane; lipid raft

Molecular Function: protein binding; IgG binding; receptor signaling protein activity; immunoglobulin binding

Biological Process: negative regulation of phagocytosis; receptor-mediated endocytosis; negative regulation of interleukin-10 production; negative regulation of acute inflammatory response to antigenic stimulus; negative regulation of immune response; antigen processing and presentation of exogenous peptide antigen via MHC class II; defense response; negative regulation of B cell proliferation; endocytic recycling; negative regulation of type I hypersensitivity; mast cell activation; negative regulation of neutrophil apoptosis; negative regulation of humoral immune response mediated by circulating immunoglobulin; cell surface receptor linked signal transduction; response to bacterium; positive regulation of phagocytosis; negative regulation of immunoglobulin production; immune complex clearance; immune response; negative regulation of inflammatory response to antigenic stimulus; immunoglobulin mediated immune response; phagocytosis, engulfment