CD138 Antibody – Mouse Monoclonal

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008]

syndecan-1: Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Belongs to the syndecan proteoglycan family.

Protein type: Membrane protein, integral; Extracellular matrix; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2p24.1

Cellular Component: lysosomal lumen; protein complex; focal adhesion; cell surface; Golgi lumen; integral to plasma membrane; cytoplasm; plasma membrane; external side of plasma membrane

Molecular Function: protein C-terminus binding; protein binding; glycoprotein binding

Biological Process: phototransduction, visible light; extracellular matrix organization and biogenesis; myoblast development; response to cAMP; wound healing; glycosaminoglycan metabolic process; striated muscle cell development; response to toxin; response to glucocorticoid stimulus; lipoprotein metabolic process; pathogenesis; Wnt receptor signaling pathway through beta-catenin; Sertoli cell development; chondroitin sulfate metabolic process; odontogenesis; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; response to hydrogen peroxide; ureteric bud development; carbohydrate metabolic process; retinoid metabolic process; inflammatory response; response to calcium ion