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Chemokine (CXC Motif) Ligand 1 (CXCL1) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2138316

MBS2138316 is an antibody targeting CXCL1. Also known as Monoclonal Antibody to Chemokine (CXC Motif) Ligand 1 (CXCL1). Reactive in Rat. Host: Mouse. More details

$220 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Chemokine (CXC Motif) Ligand 1 (CXCL1), Monoclonal Antibody
Full Product Name
Monoclonal Antibody to Chemokine (CXC Motif) Ligand 1 (CXCL1)
Product Gene Name
anti-CXCL1 antibody
Product Synonym Names
CXCL1/Chemokine (CXC Motif) Ligand 1; NAP3; GRO1; GROa; GROA; MGSAA; NAP3; SCYB1; Chemokine CXCMotif Ligand 1; Melanoma Growth Stimulating Activity Alpha; Fibroblast Secretory Protein
Clonality
Monoclonal
Isotype
IgG2b Kappa
Clone Number
A7
Host
Mouse
Species Reactivity
Rat
Form/Format
Liquid; 0.01M PBS, pH7.4, containing 0.05% Proclin300, 50% glycerol.
Purity/Purification
Protein A + Protein G affinity chromatography
Concentration
1mg/mL (lot specific)
Specificity
The antibody is a mouse monoclonal antibody raised against CXCL1. It has been selected for its ability to recognize CXCL1 in immunohistochemical staining and western blotting.
Preparation and Storage
Store at 2 degree C to 8 degree C for frequent use, 20 degree C for 24 months
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Matching Pairs
Unconjugated Antibody: CXCL1 Clone #A7 (MBS2138316)
APC-CY7 Conjugated Antibody: CXCL1 Clone #A7 (MBS2127619)
Matching Pairs
Unconjugated Antibody: CXCL1 Clone #A7 (MBS2138316)
PE Conjugated Antibody: CXCL1 Clone #A7 (MBS2127624)
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Molecular Weight
10,249 Da
3D Structure
ModBase 3D Structure for P14095
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen Type
Prokaryotic Recombinant proteins/RP
Sequence of Immunogen
Ala25~Lys96
Conjugation
Unconjugated

Product Categories/Family for anti-CXCL1 antibody

Cytokine; Tumor immunity; Infection immunity; Primary
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-CXCL1 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
Application Notes for anti-CXCL1 antibody
WB: 0.52ug/mL
IHC: 520ug/mL
ICC: 520ug/mL

Immunohistochemistry (IHC) of anti-CXCL1 antibody

DAB staining on IHCP; Sample: Rat Testis Tissue; Primary Ab: 30ug/ml Mouse AntiRat NAP3 Antibody Second Ab: 2ug/mL HRPLinked Caprine AntiMouse IgG Polyclonal Antibody (Catalog: SAA544Mu19)
Mouse Anti-CXCL1 Monoclonal Antibody – Cat# MBS2138316

Immunohistochemistry (IHC) of anti-CXCL1 antibody

DAB staining on IHCP;Sample: Rat Small intestine Tissue; Primary Ab: 30ug/ml Mouse AntiRat NAP3 AntibodySecond Ab: 2ug/mL HRPLinked Caprine AntiMouse IgG Polyclonal Antibody(Catalog: SAA544Mu19)
Mouse Anti-CXCL1 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2138316

Immunohistochemistry (IHC) of anti-CXCL1 antibody

DAB staining on IHCP;Sample: Rat Stomach Tissue; Primary Ab: 30ug/ml Mouse AntiRat NAP3 AntibodySecond Ab: 2ug/mL HRPLinked Caprine AntiMouse IgG Polyclonal Antibody(Catalog: SAA544Mu19)
Mouse Anti-CXCL1 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2138316

Immunohistochemistry (IHC) of anti-CXCL1 antibody

DAB staining on IHCP;Sample: Rat Spleen Tissue; Primary Ab: 30ug/ml Mouse AntiRat NAP3 AntibodySecond Ab: 2ug/mL HRPLinked Caprine AntiMouse IgG Polyclonal Antibody(Catalog: SAA544Mu19)
Mouse Anti-CXCL1 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2138316

Immunohistochemistry (IHC) of anti-CXCL1 antibody

DAB staining on IHCP;Sample: Rat Cerebrum Tissue; Primary Ab: 30ug/ml Mouse AntiRat NAP3 AntibodySecond Ab: 2ug/mL HRPLinked Caprine AntiMouse IgG Polyclonal Antibody(Catalog: SAA544Mu19)
Mouse Anti-CXCL1 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2138316

Other Notes

Small volumes of anti-CXCL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CXCL1. It may not necessarily be applicable to this product.

NCBI GI #
13540652
NCBI GeneID
81503
NCBI Accession #
NP_110472.1
UniProt Primary Accession #
P14095
UniProt Related Accession #
P14095
GenBank Nucleotide #
NM_030845.1
NCBI Official Full Name
growth-regulated alpha protein
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 1
NCBI Official Symbol
Cxcl1
NCBI Official Synonym Symbols
Gro1; CINC-1
UniProt Protein Name
Growth-regulated alpha protein
UniProt Synonym Protein Names
C-X-C motif chemokine 1; Cytokine-induced neutrophil chemoattractant 1; CINC-1; Platelet-derived growth factor-inducible protein KC
Protein Family
Growth-regulated alpha protein
UniProt Gene Name
Cxcl1
UniProt Synonym Gene Names
Cinc1; Gro; Scyb1; CINC-1
UniProt Entry Name
GROA_RAT
NCBI Protein Information
growth-regulated alpha protein; C-X-C motif chemokine 1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha); cytokine-induced neutrophil chemoattractant 1; platelet-derived growth factor-inducible protein KC

NCBI Summary for CXCL1

acts as a neutrophil chemoattractant; may play a role in acute phase inflammatory response [RGD, Feb 2006]

UniProt Comments for CXCL1

CXCL2: Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis

Cellular Component: extracellular space

Molecular Function: growth factor activity; chemokine activity; CXCR chemokine receptor binding

Biological Process: neutrophil chemotaxis; response to amphetamine; positive regulation of potassium ion transport; response to glucocorticoid stimulus; response to lipopolysaccharide; positive regulation of leukocyte chemotaxis; response to estradiol stimulus; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; response to heat; positive regulation of superoxide release; response to molecule of bacterial origin; response to gamma radiation; immune response; acute inflammatory response
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Research Articles on CXCL1

1. IL-1beta-mediated regulation of the CXCL1 and CXCL2 genes in pancreatic beta-cells requires stimulus-induced changes in histone chemical modifications, recruitment of the NF-kappaB and STAT1 transcription factors to genomic regulatory sequences within the proximal gene promoters, and increases in phosphorylated forms of RNA polymerase II.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CXCL1 antibody

 Reference Product  PubMed Publications
 Cxcl2 antibody  >569 publications with CXCL1 and Cxcl2
 Ccl2 antibody  >545 publications with CXCL1 and Ccl2
 Il8rb antibody  >236 publications with CXCL1 and Il8rb
 Cxcl3 antibody  >100 publications with CXCL1 and Cxcl3
 Cxcl6 antibody  >77 publications with CXCL1 and Cxcl6
 Il6 antibody  >69 publications with CXCL1 and Il6
 Cxcr4 antibody  >51 publications with CXCL1 and Cxcr4
 Ccr2 antibody  >44 publications with CXCL1 and Ccr2
 Cxcr3 antibody  >33 publications with CXCL1 and Cxcr3
 Ppbp antibody  >21 publications with CXCL1 and Ppbp

Pathways associated with anti-CXCL1 antibody

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokines And Inflammatory Response (BioCarta) Pathway antibodies  Cytokines And Inflammatory Response (BioCarta) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram

Diseases associated with anti-CXCL1 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1184 publications with CXCL1 and Inflammation
 Necrosis Antibodies  >568 publications with CXCL1 and Necrosis
 Disease Models, Animal Antibodies  >434 publications with CXCL1 and Disease Models, Animal
 Lung Diseases Antibodies  >337 publications with CXCL1 and Lung Diseases
 Cardiovascular Diseases Antibodies  >198 publications with CXCL1 and Cardiovascular Diseases
 Lung Injury Antibodies  >175 publications with CXCL1 and Lung Injury
 Pneumonia Antibodies  >116 publications with CXCL1 and Pneumonia
 Wounds and Injuries Antibodies  >98 publications with CXCL1 and Wounds and Injuries
 Reperfusion Injury Antibodies  >97 publications with CXCL1 and Reperfusion Injury
 Fibrosis Antibodies  >91 publications with CXCL1 and Fibrosis

Organs/Tissues associated with anti-CXCL1 antibody

 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >36 publications with CXCL1 and Pancreas
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