Mouse Anti-CD23 Monoclonal Antibody – Cat# MBS214075

Staining of human tonsil. Formalin fixed, paraffin processed tissue. Mag. x 100 with Mouse anti human CD23 (MBS215238)

CD23 Antibody – Mouse Monoclonal

Name: CD23 Antibody; Monoclonal; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS214075
Price: 1385 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS214075

Mouse anti Human CD23 antibody, clone 1B12 recognizes the human CD23 cell surface antigen, a 45kDa glycoprotein that is a low affinity receptor for IgE. CD23 is expressed by peripheral B lymphocytes, cells of B cell chronic lymphocytic leukaemia and upon EBV… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

CD23, Monoclonal Antibody

Full Product Name

MOUSE ANTI HUMAN CD23

Product Gene Name

anti-CD23 antibody

Clonality

Monoclonal

Isotype

IgG1

Clone Number

1B12

Host

Mouse

Form/Format

Tissue Culture Supernatant - lyophilised

Preparation and Storage

Prior to reconstitution store at 4 degree C. Following reconstitution store at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of reconstitution.

Molecular Weight

36,469 Da

OMIM

151445

3D Structure

ModBase 3D Structure for P06734

Reconstitution

Reconstitute with 1.0ml distilled water. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution.
Perservative Stabilisers||0.09% Sodium Azide

Immunogen

Recombinant human CD23
Histology Positive Control Tissue||Tonsil
Fusion Partners||Spleen cells from immunised mice were fused with cells of the mouse p3-NS1-Ag4-1 myeloma cell line

Target Species

Human

Applications Tested/Suitable for anti-CD23 antibody

Immunohistology Frozen, Flow cytometry (FC/FACS), Immunohistology Paraffin*

Application Notes for anti-CD23 antibody

Immunohistology - Frozen: Minimum Dilution: 1/20; Maximum Dilution: 1/40;
Immunohistology - Paraffin: Minimum Dilution: 1/20; Maximum Dilution: 1/40; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.

Other Notes

Small volumes of anti-CD23 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD23 purchase

MBS214075 is an antibody targeting CD23. Also known as MOUSE ANTI HUMAN CD23. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD23. It may not necessarily be applicable to this product.

NCBI GI #

334085205

NCBI GeneID

2208

NCBI Accession #

NP_001193948.2

UniProt Primary Accession #

P06734

UniProt Related Accession #

P06734

GenBank Nucleotide #

NM_001207019.2

NCBI Official Full Name

low affinity immunoglobulin epsilon Fc receptor isoform b

NCBI Official Synonym Full Names

Fc fragment of IgE, low affinity II, receptor for (CD23)

NCBI Official Symbol

FCER2

NCBI Official Synonym Symbols

CD23; FCE2; CD23A; IGEBF; CLEC4J; BLAST-2

UniProt Protein Name

Low affinity immunoglobulin epsilon Fc receptor

UniProt Synonym Protein Names

BLAST-2; C-type lectin domain family 4 member J; Fc-epsilon-RII; Immunoglobulin E-binding factor; Lymphocyte IgE receptor; CD_antigen: CD23Cleaved into the following 2 chains:Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form

Protein Family

Low affinity immunoglobulin epsilon Fc receptor

UniProt Gene Name

FCER2

UniProt Synonym Gene Names

CD23A; CLEC4J; FCE2; IGEBF

UniProt Entry Name

FCER2_HUMAN

NCBI Protein Information

low affinity immunoglobulin epsilon Fc receptor; C-type lectin domain family 4, member J; CD23 antigen; fc-epsilon-RII; immunoglobulin E-binding factor; lymphocyte IgE receptor

NCBI Summary for CD23

The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

UniProt Comments for CD23

Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).

Research Articles on CD23

1. Crystal structure of the CD23-Fc3-4 complex with different molecular-packing constraints.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CD23 antibody

Products by Pathway	Pathway Diagram
Epstein-Barr Virus Infection Pathway antibodies	Epstein-Barr Virus Infection Pathway Diagram
Epstein-Barr Virus Infection Pathway antibodies	Epstein-Barr Virus Infection Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
IL-3 Signaling Pathway antibodies	IL-3 Signaling Pathway Diagram
IL4-mediated Signaling Events Pathway antibodies	IL4-mediated Signaling Events Pathway Diagram
NOTCH2 Intracellular Domain Regulates Transcription Pathway antibodies	NOTCH2 Intracellular Domain Regulates Transcription Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By NOTCH Pathway antibodies	Signaling By NOTCH Pathway Diagram
Signaling By NOTCH2 Pathway antibodies	Signaling By NOTCH2 Pathway Diagram

Diseases associated with anti-CD23 antibody

Disease Name	Pubmed Publications
Asthma Antibodies	>17 publications with CD23 and Asthma
Lung Diseases Antibodies	>15 publications with CD23 and Lung Diseases
Respiratory Hypersensitivity Antibodies	>14 publications with CD23 and Respiratory Hypersensitivity
Hypersensitivity Antibodies	>14 publications with CD23 and Hypersensitivity
Hypersensitivity, Immediate Antibodies	>14 publications with CD23 and Hypersensitivity, Immediate
Inflammation Antibodies	>2 publications with CD23 and Inflammation
Carcinoma Antibodies	>1 publications with CD23 and Carcinoma
Intestinal Diseases Antibodies	>1 publications with CD23 and Intestinal Diseases
Hyperplasia Antibodies	>1 publications with CD23 and Hyperplasia
Bronchial Hyperreactivity Antibodies	>1 publications with CD23 and Bronchial Hyperreactivity

Organs/Tissues associated with anti-CD23 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>10 publications with CD23 and Blood
Lymph Node Antibodies	>1 publications with CD23 and Lymph Node
Spleen Antibodies	>1 publications with CD23 and Spleen