Rat Anti-CD273 Monoclonal Antibody – Cat# MBS214325

CD273 Antibody – Rat Monoclonal

Name: CD273 Antibody; Monoclonal; Rat; MyBioSource
Brand: MyBioSource
SKU: MBS214325
Price: 510 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS214325

Rat anti Mouse CD273 antibody, clone TY25 recognises mouse CD273, a 42kD member of the B7 family, otherwise known as B7-dendritic cell (B7-DC), or programmed death ligand-2 (PD-L2). The expression of CD273 is restricted to a subpopulation of dendritic cells… More details

$510 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CD273, Monoclonal Antibody

Full Product Name

RAT ANTI MOUSE CD273:FITC

Product Gene Name

anti-CD273 antibody

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

TY25

Host

Rat

Form/Format

FITC
Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid

Concentration

IgG concentration 0.1 mg/ml (lot specific)

Preparation and Storage

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Molecular Weight

27,820 Da

3D Structure

ModBase 3D Structure for Q9WUL5

Perservative Stabilisers

0.09% Sodium Azide
1% Bovine Serum Albumin
Preparation||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Buffer Solution

Phosphate buffered saline

Target Species

Mouse

Applications Tested/Suitable for anti-CD273 antibody

Flow cytometry (FC/FACS)

Application Notes for anti-CD273 antibody

Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity Fc receptors. This may be reduced by using SeroBlock FcR
Flow Cytometry: Minimum Dilution: Neat; Maximum Dilution: 1/5

Other Notes

Small volumes of anti-CD273 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD273 purchase

MBS214325 is an antibody targeting CD273. Also known as RAT ANTI MOUSE CD273:FITC. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for CD273. It may not necessarily be applicable to this product.

NCBI GI #

10946740

NCBI GeneID

58205

NCBI Accession #

NP_067371.1

UniProt Primary Accession #

Q9WUL5

UniProt Related Accession #

Q9WUL5

GenBank Nucleotide #

NM_021396.2

NCBI Official Full Name

programmed cell death 1 ligand 2

NCBI Official Synonym Full Names

programmed cell death 1 ligand 2

NCBI Official Symbol

Pdcd1lg2

NCBI Official Synonym Symbols

Btdc; B7-DC; PD-L2; F730015O22Rik

UniProt Protein Name

Programmed cell death 1 ligand 2

UniProt Synonym Protein Names

Butyrophilin B7-DC; B7-DC; CD_antigen: CD273

Protein Family

Programmed cell death

UniProt Gene Name

Pdcd1lg2

UniProt Synonym Gene Names

B7dc; Btdc; Cd273; Pdl2; PD-1 ligand 2; PD-L2; PDCD1 ligand 2; Programmed death ligand 2; B7-DC

UniProt Entry Name

PD1L2_MOUSE

NCBI Protein Information

programmed cell death 1 ligand 2; PD-1 ligand 2; PDCD1 ligand 2; butyrophilin B7-DC; butyrophilin-like protein; programmed death ligand 2

UniProt Comments for CD273

PDCD1LG2: Involved in the costimulatory signal, essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production. Belongs to the immunoglobulin superfamily. BTN/MOG family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Cellular Component: membrane; integral to membrane; plasma membrane

Molecular Function: protein binding

Biological Process: negative regulation of T cell proliferation; negative regulation of interleukin-10 production; negative regulation of activated T cell proliferation; negative regulation of interferon-gamma production; positive regulation of T cell proliferation

Research Articles on CD273

1. This study reveals DOK3 as a nonredundant regulator of plasma cell differentiation by up-regulating PD-1 ligand expression through the attenuation of calcium signaling.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CD273 antibody

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Costimulation By The CD28 Family Pathway antibodies	Costimulation By The CD28 Family Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
PD-1 Signaling Pathway antibodies	PD-1 Signaling Pathway Diagram

Diseases associated with anti-CD273 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>28 publications with CD273 and Inflammation
Necrosis Antibodies	>16 publications with CD273 and Necrosis
Carcinoma Antibodies	>13 publications with CD273 and Carcinoma
Nervous System Diseases Antibodies	>12 publications with CD273 and Nervous System Diseases
Lung Diseases Antibodies	>12 publications with CD273 and Lung Diseases
Adenocarcinoma Antibodies	>8 publications with CD273 and Adenocarcinoma
Cardiovascular Diseases Antibodies	>7 publications with CD273 and Cardiovascular Diseases
Liver Neoplasms Antibodies	>5 publications with CD273 and Liver Neoplasms
Kidney Diseases Antibodies	>4 publications with CD273 and Kidney Diseases
Lung Neoplasms Antibodies	>4 publications with CD273 and Lung Neoplasms

Organs/Tissues associated with anti-CD273 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>9 publications with CD273 and Brain
Skin Antibodies	>5 publications with CD273 and Skin
Thymus Antibodies	>2 publications with CD273 and Thymus