Rabbit Anti-uPA Polyclonal Antibody – Cat# MBS2143720

Plasminogen Activator, Urokinase (uPA) Antibody – Rabbit Polyclonal

Name: uPA Antibody; Polyclonal; Rabbit; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS2143720
Price: 215 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2143720

MBS2143720 is an antibody targeting uPA. Also known as Biotin-Linked Polyclonal Antibody to Plasminogen Activator, Urokinase (uPA). Reactive in Mouse. Host: Rabbit. More details

$215 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Plasminogen Activator, Urokinase (uPA), Polyclonal Antibody

Full Product Name

Biotin-Linked Polyclonal Antibody to Plasminogen Activator, Urokinase (uPA)

Product Gene Name

anti-uPA antibody

Product Synonym Names

Plasminogen Activator, Urokinase; PLAU; ATF; URK; UK; UP-A; Abbokinase; Urokinase-Type Plasminogen Activator

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Mouse

Form/Format

Liquid. PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.

Purity/Purification

Affinity Chromatography

Concentration

>=0.5mg/mL (Please refer to the vial label for the specific concentration.) (lot specific)

Preparation and Storage

Store at 2 degree C to 8 degree C for frequent use, -20 degree C for 12 months
Stable for 12 months if correctly stored.

Matching Pairs

Antibody: uPA (MBS2143720)
Immunogen: uPA (MBS2031074)

Matching Pairs

Unconjugated Antibody: uPA (MBS2151619)
Biotin Conjugated Antibody: uPA (MBS2143720)

Molecular Weight

160,000

Immunogen Sequence Positions

Ile180~Phe433

Chromosome Location

Chromosome: 14; NC_000080.6 (20836662..20843388). Location: 14 A3; 14 11.53 cM

3D Structure

ModBase 3D Structure for P06869

Supply Chain Verification

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Conjugation

Biotin

Product Categories/Family for anti-uPA antibody

Polyclonal Antibodies (Primary Abs); Primary, Biotin-conjugated; Tumor immunity

ISO Certification

Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.

Applications Tested/Suitable for anti-uPA antibody

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Application Notes for anti-uPA antibody

WB: 0.5-2ug/mL
IHC: 5-20ug/mL
ICC: 5-20ug/mL

Other Notes

Small volumes of anti-uPA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for uPA. It may not necessarily be applicable to this product.

NCBI GI #

6679377

NCBI GeneID

18792

NCBI Accession #

NP_032899.1

UniProt Primary Accession #

P06869

UniProt Related Accession #

P06869

GenBank Nucleotide #

NM_008873.3

NCBI Official Full Name

urokinase-type plasminogen activator

NCBI Official Synonym Full Names

plasminogen activator, urokinase

NCBI Official Symbol

Plau

NCBI Official Synonym Symbols

uPA; u-PA

UniProt Protein Name

Urokinase-type plasminogen activator

UniProt Gene Name

Plau

UniProt Synonym Gene Names

U-plasminogen activator; uPA

UniProt Entry Name

UROK_MOUSE

NCBI Protein Information

urokinase-type plasminogen activator; U-plasminogen activator

UniProt Comments for uPA

uPA: Specifically cleave the zymogen plasminogen to form the active enzyme plasmin. Defects in PLAU are the cause of Quebec platelet disorder (QPD). QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Protease; EC 3.4.21.73; Secreted; Motility/polarity/chemotaxis

Cellular Component: extracellular space; focal adhesion; cell surface; membrane; extracellular region

Molecular Function: peptidase activity; hydrolase activity; serine-type peptidase activity; serine-type endopeptidase activity; catalytic activity

Biological Process: wound healing; smooth muscle cell migration; skeletal muscle regeneration; positive regulation of smooth muscle cell migration; proteolysis; regulation of cell proliferation; regulation of cell adhesion mediated by integrin; fibrinolysis; regulation of smooth muscle cell migration; positive regulation of cell proliferation; response to hypoxia; regulation of receptor activity; angiogenesis

Research Articles on uPA

1. uPA's dual effects on tumor progression occur in the context of its interactions with endogenous PAI-1 expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-uPA antibody

Products by Pathway	Pathway Diagram
Blood Clotting Cascade Pathway antibodies	Blood Clotting Cascade Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Dissolution Of Fibrin Clot Pathway antibodies	Dissolution Of Fibrin Clot Pathway Diagram
Endochondral Ossification Pathway antibodies	Endochondral Ossification Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
NF-kappa B Signaling Pathway antibodies	NF-kappa B Signaling Pathway Diagram
Proteoglycans In Cancer Pathway antibodies	Proteoglycans In Cancer Pathway Diagram
Proteoglycans In Cancer Pathway antibodies	Proteoglycans In Cancer Pathway Diagram

Diseases associated with anti-uPA antibody

Disease Name	Pubmed Publications
Adenocarcinoma Antibodies	>15 publications with uPA and Adenocarcinoma
Alzheimer Disease Antibodies	>14 publications with uPA and Alzheimer Disease
Inflammation Antibodies	>13 publications with uPA and Inflammation
Neoplasm Invasiveness Antibodies	>9 publications with uPA and Neoplasm Invasiveness
Prostatic Neoplasms Antibodies	>8 publications with uPA and Prostatic Neoplasms
Neoplasm Metastasis Antibodies	>7 publications with uPA and Neoplasm Metastasis
Stomach Neoplasms Antibodies	>5 publications with uPA and Stomach Neoplasms
Pancreatic Neoplasms Antibodies	>4 publications with uPA and Pancreatic Neoplasms
Hemorrhage Antibodies	>3 publications with uPA and Hemorrhage
Necrosis Antibodies	>2 publications with uPA and Necrosis

Organs/Tissues associated with anti-uPA antibody

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>5 publications with uPA and Kidney
Connective Tissue Antibodies	>3 publications with uPA and Connective Tissue
Ovary Antibodies	>2 publications with uPA and Ovary
Mammary Gland Antibodies	>2 publications with uPA and Mammary Gland