hnRNPK Antibody – Mouse Monoclonal

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progession. Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized. [provided by RefSeq, Jul 2008]

hnRNP K: a heterogeneous nuclear ribonucleoprotein (hnRNP). One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Two alternatively spliced isoforms have been described.

Protein type: Spliceosome; RNA splicing; RNA-binding

Chromosomal Location of Human Ortholog: 9q21.32-q21.33

Cellular Component: nucleoplasm; focal adhesion; cell projection; membrane; nuclear chromatin; cytoplasm; podosome; nucleus

Molecular Function: protein binding; RNA binding; single-stranded DNA binding

Biological Process: RNA processing; nuclear mRNA splicing, via spliceosome; viral reproduction; transcription, DNA-dependent; RNA splicing; positive regulation of low-density lipoprotein receptor biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; gene expression; signal transduction; positive regulation of receptor-mediated endocytosis