Mouse Anti-BKRF1 Monoclonal Antibody – Cat# MBS214468

EPSTEIN-BARR VIRUS NUCLEAR ANTIGEN (BKRF1) Antibody – Mouse Monoclonal

Name: BKRF1 Antibody; Monoclonal; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS214468
Price: 440 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS214468

MBS214468 specifically recognises the repetitive Gly-Ala region of EBV (Epstein-Barr Virus) nuclear antigen 1 (EBNA-1), a viral protein expressed consistently by EBV- associated malignancies. Epstein-Barr Virus, also known as HHV-4 (Human herpesvirus 4), is a… More details

$440 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

EPSTEIN-BARR VIRUS NUCLEAR ANTIGEN (BKRF1), Monoclonal Antibody

Full Product Name

MOUSE ANTI EPSTEIN-BARR VIRUS NUCLEAR ANTIGEN

Product Gene Name

anti-BKRF1 antibody

Clonality

Monoclonal

Isotype

IgG2b

Clone Number

E1-2.5

Host

Mouse

Form/Format

Purified
Purified IgG - liquid

Concentration

IgG concentration 1.0mg/ml (lot specific)

Specificity

This item specifically recognises the repetitive Gly-Ala region of EBV (Epstein-Barr Virus) nuclear antigen 1 (EBNA-1), a viral protein expressed consistently by EBV- associated malignancies.

Epstein-Barr Virus, also known as HHV-4 (Human herpesvirus 4), is a member of the herpesvirus family and one of the most common infectious viruses known, being responsible for a wide range of illnesses from infectious mononucleosis to nasal-pharyngeal cancer. EBNA-1 is the only viral protein expressed during group 1 latency and mediates the replication and partitioning of the episome during host cell division, binding to a replication origin (oriP) within the viral genome. The Gly-Ala repeat recognized by This item, inhibits the host's CD8-restricted cytotoxic T-cell response to infected cells, by impairing antigen processing and MHC class I-restricted antigen presentation.

This item is reported as being suitable for use in immunocytochemistry.

Preparation and Storage

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Molecular Weight

56,427 Da

3D Structure

ModBase 3D Structure for P03211

Perservative Stabilisers

0.09% Sodium Azide (NaN3)
Preparation||Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant

Buffer Solution

Phosphate buffered saline

Target Species

Viral

Applications Tested/Suitable for anti-BKRF1 antibody

ELISA (EIA)

Other Notes

Small volumes of anti-BKRF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BKRF1 purchase

MBS214468 is an antibody targeting BKRF1. Also known as MOUSE ANTI EPSTEIN-BARR VIRUS NUCLEAR ANTIGEN. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for BKRF1. It may not necessarily be applicable to this product.

NCBI GI #

82503233

NCBI GeneID

3783709

NCBI Accession #

YP_401677.1

UniProt Primary Accession #

P03211

UniProt Secondary Accession #

Q777E1

GenBank Nucleotide #

NC_007605.1

NCBI Official Full Name

EBNA-1 protein

NCBI Official Symbol

BKRF1

UniProt Protein Name

Epstein-Barr nuclear antigen 1

UniProt Gene Name

EBNA1

UniProt Synonym Gene Names

EBNA-1; EBV nuclear antigen 1

UniProt Entry Name

EBNA1_EBVB9

NCBI Protein Information

EBNA-1 protein

UniProt Comments for BKRF1

Plays an essential role in replication and partitioning of viral genomic DNA during latent viral infection. During this phase, the circular double-stranded viral DNA undergoes replication once per cell cycle and is efficiently partitioned to the daughter cells. EBNA1 activates the initiation of viral DNA replication through binding to specific sites in the viral latent origin of replication, oriP. Additionally, it governs the segregation of viral episomes by mediating their attachment to host cell metaphase chromosomes. Also activates the transcription of several viral latency genes. Finally, it can counteract the stabilization of host p53/TP53 by host USP7, thereby decreasing apoptosis and increasing host cell survival.

Research Articles on BKRF1

1. Epstein-Barr virus EBNA1 protein regulates viral latency through effects on let-7 microRNA and dicer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.