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KCNN2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2144882
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MBS2144882 is an antibody targeting KCNN2. Also known as Biotin-Linked Polyclonal Antibody to PotassuM Intermediate Small Conductance CalcuM Activated Channel Subfamily N, Member 2 (KCNN2). Reactive in Human. Host: Rabbit. More details

$235 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PotassuM Intermediate Small Conductance CalcuM Activated Channel Subfamily N, Member 2 (KCNN2), Polyclonal Antibody
Full Product Name
Biotin-Linked Polyclonal Antibody to PotassuM Intermediate Small Conductance CalcuM Activated Channel Subfamily N, Member 2 (KCNN2)
Product Gene Name
anti-KCNN2 antibody
Product Synonym Names
PotassuM Intermediate Small Conductance CalcuM Activated Channel Subfamily N, Member 2; KCa2.2; SK2; SKCA2; hSK2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
>=0.5mg/mL (Please refer to the vial label for the specific concentration.) (lot specific)
Preparation and Storage
Store at 2 degree C to 8 degree C for frequent use, -20 degree C for 12 months
Stable for 12 months if correctly stored.
Matching Pairs
Antibody: KCNN2 (MBS2144882)
Immunogen: KCNN2 (MBS2124671)
Matching Pairs
Unconjugated Antibody: KCNN2 (MBS2152779)
Biotin Conjugated Antibody: KCNN2 (MBS2144882)
Molecular Weight
63,760 Da
Immunogen Sequence Positions
Lys466~Ser579
OMIM
605879
3D Structure
ModBase 3D Structure for Q9H2S1
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Conjugation
Biotin

Product Categories/Family for anti-KCNN2 antibody

Polyclonal Antibodies (Primary Abs); Primary, Biotin-conjugated; Signal transduction
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-KCNN2 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
Application Notes for anti-KCNN2 antibody
WB: 0.2-2ug/mL, 1:250-2500
IHC: 5-20ug/mL, 1:25-100
ICC: 5-20ug/mL, 1:25-100

Other Notes

Small volumes of anti-KCNN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for KCNN2. It may not necessarily be applicable to this product.

NCBI GI #
578810350
NCBI GeneID
3781
NCBI Accession #
XP_006714676.1
UniProt Primary Accession #
Q9H2S1
UniProt Secondary Accession #
Q0VFZ4; Q6PJI0; Q6X2Y2; A6NF94
UniProt Related Accession #
Q9H2S1
GenBank Nucleotide #
XM_006714613.1
NCBI Official Full Name
small conductance calcium-activated potassium channel protein 2 isoform X1
NCBI Official Synonym Full Names
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
NCBI Official Symbol
KCNN2
NCBI Official Synonym Symbols
SK2; hSK2; SKCA2; KCa2.2; SKCa 2
UniProt Protein Name
Small conductance calcium-activated potassium channel protein 2
UniProt Synonym Protein Names
KCa2.2
Protein Family
Small conductance calcium-activated potassium channel protein
UniProt Gene Name
KCNN2
UniProt Synonym Gene Names
SK2; SKCa 2; SKCa2
UniProt Entry Name
KCNN2_HUMAN
NCBI Protein Information
small conductance calcium-activated potassium channel protein 2; apamin-sensitive small-conductance Ca2+-activated potassium channel

NCBI Summary for KCNN2

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
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UniProt Comments for KCNN2

KCNN2: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. Belongs to the potassium channel KCNN family. KCa2.2/KCNN2 subfamily.

Protein type: Membrane protein, integral; Channel, potassium; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 5q22.3

Cellular Component: smooth endoplasmic reticulum; cell soma; T-tubule; plasma membrane; integral to membrane; dendritic spine; Z disc

Molecular Function: calmodulin binding; calcium-activated potassium channel activity; protein homodimerization activity; alpha-actinin binding; small conductance calcium-activated potassium channel activity

Biological Process: synaptic transmission; potassium ion transport
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Research Articles on KCNN2

1. KCNN2 gene can have an important role in the development of coronary artery aneurysms in Kawasaki disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KCNN2 antibody

 Reference Product  PubMed Publications
 KCNN3 antibody  >29 publications with KCNN2 and KCNN3
 KCNN1 antibody  >27 publications with KCNN2 and KCNN1
 ACTN2 antibody  >2 publications with KCNN2 and ACTN2

Pathways associated with anti-KCNN2 antibody

 Products by Pathway  Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Ca2+ Activated K+ Channels Pathway antibodies  Ca2+ Activated K+ Channels Pathway Diagram
 Insulin Secretion Pathway antibodies  Insulin Secretion Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 Serotonergic Synapse Pathway antibodies  Serotonergic Synapse Pathway Diagram

Diseases associated with anti-KCNN2 antibody

 Disease Name  Pubmed Publications
 Arrhythmias, Cardiac Antibodies  >7 publications with KCNN2 and Arrhythmias, Cardiac
 Disease Models, Animal Antibodies  >5 publications with KCNN2 and Disease Models, Animal
 Neurobehavioral Manifestations Antibodies  >4 publications with KCNN2 and Neurobehavioral Manifestations
 Learning Disorders Antibodies  >2 publications with KCNN2 and Learning Disorders
 Pain Antibodies  >2 publications with KCNN2 and Pain
 Inflammation Antibodies  >2 publications with KCNN2 and Inflammation
 Hypotension Antibodies  >1 publications with KCNN2 and Hypotension
 Liver Diseases Antibodies  >1 publications with KCNN2 and Liver Diseases
 Mental Disorders Antibodies  >1 publications with KCNN2 and Mental Disorders
 Hypertension Antibodies  >1 publications with KCNN2 and Hypertension

Organs/Tissues associated with anti-KCNN2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >47 publications with KCNN2 and Brain
 Ear Antibodies  >11 publications with KCNN2 and Ear
 Kidney Antibodies  >8 publications with KCNN2 and Kidney
 Adrenal Gland Antibodies  >3 publications with KCNN2 and Adrenal Gland
 Prostate Antibodies  >2 publications with KCNN2 and Prostate
 Embryonic Tissue Antibodies  >2 publications with KCNN2 and Embryonic Tissue
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