Ferritin, Heavy Polypeptide (FTH) Antibody – Mouse Monoclonal

Ferritin-H: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited. Belongs to the ferritin family.

Protein type: Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Oxidoreductase; EC 1.16.3.1

Cellular Component: mitochondrion; nucleus

Molecular Function: ferric iron binding; ferroxidase activity; metal ion binding; oxidoreductase activity

Biological Process: cellular iron ion homeostasis; intracellular sequestering of iron ion; iron ion transport; negative regulation of fibroblast proliferation