Peroxisome Proliferator Activated Receptor Alpha (PPARa) Antibody – Rabbit Polyclonal

PPAR-alpha: Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. Belongs to the nuclear hormone receptor family. NR1 subfamily.

Protein type: DNA-binding; Nuclear receptor

Cellular Component: nucleus

Molecular Function: protein domain specific binding; ligand-dependent nuclear receptor activity; NFAT protein binding; zinc ion binding; metal ion binding; receptor activity; drug binding; phosphatase binding; protein binding; DNA binding; ubiquitin conjugating enzyme binding; sequence-specific DNA binding; protein heterodimerization activity; protein complex binding; steroid hormone receptor activity; lipid binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; epidermis development; wound healing; positive regulation of transcription, DNA-dependent; rhythmic process; behavioral response to nicotine; negative regulation of transcription from RNA polymerase II promoter; fatty acid metabolic process; negative regulation of appetite; response to insulin stimulus; positive regulation of gluconeogenesis; regulation of transcription, DNA-dependent; regulation of fatty acid metabolic process; negative regulation of blood pressure; circadian regulation of gene expression; negative regulation of protein binding; intracellular receptor-mediated signaling pathway; transcription, DNA-dependent; glucose metabolic process; lipoprotein metabolic process; regulation of circadian rhythm; regulation of gene expression; positive regulation of fatty acid oxidation; response to hypoxia; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; lipid metabolic process