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IAPP Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS245007

Islet of insulinoma amyloid polypeptide (IAPP) is a 37 amino acids monomeric polypeptide isolated from pancreatic amyloid. It is commonly found in the islet of patients with diabetes mellitus type II and in insulinomas. IAPP selectively inhibits… More details

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Product Overview

Online Datasheet in PDF
Product Name
IAPP / Amylin, Monoclonal Antibody
Full Product Name
Mouse Monoclonal [clone R10/99] (IgG1) to Human IAPP / Amylin
Product Gene Name
Product Synonym Names
Anti-IAPP / Amylin Antibody (clone R10/99) IHC-plus; IAPP; Diabetes-associated peptide; Islet amyloid polypeptide; AMYLIN; IAP; Insulinoma amyloid peptide; Human IAPP; Amylin
Clonality
Monoclonal
Isotype
IgG1
Clone Number
R10/99
Host
Mouse
Species Reactivity
Human
Form/Format
Tissue culture supernatant, 0.09% sodium azide. Sourced in TCS.
Purity/Purification
Tissue culture supernatant
Preparation and Storage
Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
Molecular Weight
9,806 Da
OMIM
147940
3D Structure
ModBase 3D Structure for P10997
Target Species
Human
Immunogen Description
CATQRLANFLV coupled to tuberculin.
Immunogen Type
Synthetic peptide
Immunogen
IAPP / Amylin antibody was raised against cATQRLANFLV coupled to tuberculin.
Applications Tested/Suitable for anti-IAPP antibody
Immunohistochemistry (IHC - Paraffin, IHC - Frozen), Immunofluorescence (IF)
Application Notes for anti-IAPP antibody
IF, IHC-Fr, IHC-P (1:100)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibo...

Immunohistochemistry (IHC) of anti-IAPP antibody

Anti-Amylin antibody IHC of human pancreas, islet of Langerhans. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Mouse Anti-IAPP Monoclonal Antibody – Cat# MBS245007

Other Notes

Small volumes of anti-IAPP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IAPP purchase

MBS245007 is an antibody targeting IAPP. Also known as Mouse Monoclonal [clone R10/99] (IgG1) to Human IAPP / Amylin. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for IAPP. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
islet amyloid polypeptide
NCBI Official Synonym Full Names
islet amyloid polypeptide
NCBI Official Symbol
IAPP
NCBI Official Synonym Symbols
DAP; IAP
UniProt Protein Name
Islet amyloid polypeptide
UniProt Synonym Protein Names
Amylin; Diabetes-associated peptide; DAP; Insulinoma amyloid peptide
UniProt Gene Name
IAPP
UniProt Synonym Gene Names
DAP
UniProt Entry Name
IAPP_HUMAN
NCBI Protein Information
islet amyloid polypeptide; amylin; insulinoma amyloid peptide; diabetes-associated peptide; Islet amyloid polypeptide (diabetes-associated peptide; amylin)

NCBI Summary for IAPP

The protein encoded by this gene is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. Studies suggest that this protein, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes. This protein also exhibits an bactericidal, antimicrobial activity. [provided by RefSeq, Sep 2014]
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UniProt Comments for IAPP

IAPP: Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. Belongs to the calcitonin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12p12.1

Cellular Component: extracellular space; cell soma; extracellular region

Molecular Function: identical protein binding; hormone activity; receptor binding

Biological Process: negative regulation of cell differentiation; cell-cell signaling; eating behavior; apoptosis; negative regulation of bone resorption; sensory perception of pain; signal transduction; endocrine pancreas development
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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