Rabbit Anti-ARG2 Polyclonal Antibody – Cat# MBS2152808

Arginase II (ARG2) Antibody – Rabbit Polyclonal

Name: ARG2 Antibody; Polyclonal; Rabbit; Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS2152808
Price: 220 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2152808

MBS2152808 is an antibody targeting Arg2. Also known as Polyclonal Antibody to Arginase II (Arg2). Reactive in Rat. Host: Rabbit. More details

$220 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Arginase II (Arg2), Polyclonal Antibody

Full Product Name

Polyclonal Antibody to Arginase II (Arg2)

Product Gene Name

anti-Arg2 antibody

Product Synonym Names

Arginase II; Kidney-type arginase; Non-hepatic arginase

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Rat

Form/Format

Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

Purity/Purification

Affinity Chromatography

Concentration

0.5mg/mL (lot specific)

Specificity

The antibody is a rabbit polyclonal antibody raised against Arg2. It has been selected for its ability to recognize Arg2 in immunohistochemical staining and western blotting.

Preparation and Storage

Store at 4 degree C for frequent use. Store at -20 degree C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Stable for 12 months if correctly stored.
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Matching Pairs

Antibody: Arg2 (MBS2152808)
Immunogen: Arg2 (MBS2011528)

Matching Pairs

Unconjugated Antibody: Arg2 (MBS2152808)
HRP Conjugated Antibody: Arg2 (MBS2141752)

Molecular Weight

38,640 Da

Immunogen Sequence Positions

Val23~Ile354

3D Structure

ModBase 3D Structure for O08701

Supply Chain Verification

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Product Categories/Family for anti-Arg2 antibody

Polyclonal Antibodies (Primary Abs); Polyclonal antibodies; Infection immunity

ISO Certification

Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.

Applications Tested/Suitable for anti-Arg2 antibody

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Application Notes for anti-Arg2 antibody

WB: 0.5-2ug/mL
IHC: 5-20ug/mL
ICC: 5-20ug/mL

Other Notes

Small volumes of anti-Arg2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Arg2. It may not necessarily be applicable to this product.

NCBI GI #

9506399

NCBI GeneID

29215

NCBI Accession #

NP_062041.1

UniProt Primary Accession #

O08701

UniProt Secondary Accession #

P97539

UniProt Related Accession #

O08701

GenBank Nucleotide #

NM_019168.1

NCBI Official Full Name

arginase-2, mitochondrial

NCBI Official Synonym Full Names

arginase 2

NCBI Official Symbol

Arg2

UniProt Protein Name

Arginase-2, mitochondrial

UniProt Synonym Protein Names

Arginase II; Kidney-type arginase; Non-hepatic arginase; Type II arginase

Protein Family

Arginase

UniProt Gene Name

Arg2

NCBI Protein Information

arginase-2, mitochondrial

NCBI Summary for Arg2

catalyzes the hydrolysis of arginine to ornithine and urea; may regulate nitric oxide production [RGD, Feb 2006]

UniProt Comments for Arg2

May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May play a role in promoting prenatal immune suppression. Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction. Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling. Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity.

Research Articles on Arg2

1. Tissue-specific up-regulation of arginase I and II induced by p38 MAPK mediates endothelial dysfunction in type 1 diabetes mellitus

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Arg2 antibody

Products by Pathway	Pathway Diagram
Amoebiasis Pathway antibodies	Amoebiasis Pathway Diagram
Amoebiasis Pathway antibodies	Amoebiasis Pathway Diagram
Arginine And Proline Metabolism Pathway antibodies	Arginine And Proline Metabolism Pathway Diagram
Arginine And Proline Metabolism Pathway antibodies	Arginine And Proline Metabolism Pathway Diagram
Biosynthesis Of Amino Acids Pathway antibodies	Biosynthesis Of Amino Acids Pathway Diagram
Biosynthesis Of Amino Acids Pathway antibodies	Biosynthesis Of Amino Acids Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram
Polyamine Biosynthesis, Arginine => Ornithine => Putrescine Pathway antibodies	Polyamine Biosynthesis, Arginine => Ornithine => Putrescine Pathway Diagram
Polyamine Biosynthesis, Arginine => Ornithine => Putrescine Pathway antibodies	Polyamine Biosynthesis, Arginine => Ornithine => Putrescine Pathway Diagram
Urea Cycle Pathway antibodies	Urea Cycle Pathway Diagram

Diseases associated with anti-Arg2 antibody

Disease Name	Pubmed Publications
Disease Models, Animal Antibodies	>24 publications with Arg2 and Disease Models, Animal
Inflammation Antibodies	>22 publications with Arg2 and Inflammation
Cardiovascular Diseases Antibodies	>21 publications with Arg2 and Cardiovascular Diseases
Nervous System Diseases Antibodies	>18 publications with Arg2 and Nervous System Diseases
Lung Diseases Antibodies	>16 publications with Arg2 and Lung Diseases
Brain Diseases Antibodies	>13 publications with Arg2 and Brain Diseases
Asthma Antibodies	>12 publications with Arg2 and Asthma
Kidney Diseases Antibodies	>10 publications with Arg2 and Kidney Diseases
Hypertension Antibodies	>10 publications with Arg2 and Hypertension
Heart Diseases Antibodies	>6 publications with Arg2 and Heart Diseases

Organs/Tissues associated with anti-Arg2 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>64 publications with Arg2 and Brain
Kidney Antibodies	>31 publications with Arg2 and Kidney
Liver Antibodies	>23 publications with Arg2 and Liver
Small Intestine Antibodies	>17 publications with Arg2 and Small Intestine
Pancreas Antibodies	>6 publications with Arg2 and Pancreas
Prostate Antibodies	>6 publications with Arg2 and Prostate
Placenta Antibodies	>3 publications with Arg2 and Placenta
Thymus Antibodies	>3 publications with Arg2 and Thymus