Phospholipase B (PLB) Antibody – Mouse Monoclonal

This gene encodes a membrane-associated phospholipase that displays lysophospholipase and phospholipase A2 activities through removal of sn-1 and sn-2 fatty acids of glycerophospholipids. In addition, it displays lipase and retinyl ester hydrolase activities. The encoded protein is highly conserved and is composed of a large, glycosylated extracellular domain composed of four tandem homologous domains, followed by a hydrophobic segment that anchors the enzyme to the membrane and a short C-terminal cytoplasmic tail. This gene has been identified as a candidate rheumatoid arthritis risk gene. [provided by RefSeq, Jul 2016]

PLB1: Membrane-associated phospholipase. Exhibits a calcium- independent broad substrate specificity including phospholipase A2/lysophospholipase activity. Preferential hydrolysis at the sn-2 position of diacylphospholipids and diacyglycerol, whereas it shows no positional specificity toward triacylglycerol. Exhibits also esterase activity toward p-nitrophenyl. May act on the brush border membrane to facilitate the absorption of digested lipids. Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.1.4; EC 3.1.1.5; Membrane protein, integral; Phospholipase

Chromosomal Location of Human Ortholog: 2p23.2

Cellular Component: apical plasma membrane; integral component of membrane; plasma membrane

Molecular Function: lysophospholipase activity; phospholipase A2 activity; retinyl-palmitate esterase activity

Biological Process: lipid catabolic process; retinoid metabolic process; retinol metabolic process