CD120a Antibody – Rat Monoclonal

TNF-R1: Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4, BRE, FEM1B, GRB2, SQSTM1 and TRPC4AP. Interacts with HCV core protein. Interacts with human cytomegalovirus/HHV-5 protein UL138. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, cytokine; Membrane protein, integral

Cellular Component: Golgi apparatus; extracellular space; cell surface; protein complex; mitochondrion; integral to membrane; cytosol; lipid raft; Golgi membrane; membrane; axon; plasma membrane; synapse; intracellular; nucleus; receptor complex

Molecular Function: protein binding; tumor necrosis factor receptor activity; protease binding; protein complex binding; tumor necrosis factor binding

Biological Process: positive regulation of protein import into nucleus, translocation; protein heterooligomerization; apoptosis; cytokine and chemokine mediated signaling pathway; programmed cell death; defense response; positive regulation of tumor necrosis factor production; signal transduction; prostaglandin metabolic process; regulation of apoptosis; positive regulation of angiogenesis; positive regulation of tyrosine phosphorylation of Stat1 protein; cell surface receptor linked signal transduction; DNA damage response, signal transduction resulting in induction of apoptosis; tumor necrosis factor-mediated signaling pathway; negative regulation of inflammatory response; positive regulation of neuron apoptosis; defense response to bacterium; negative regulation of interleukin-6 production; positive regulation of transcription from RNA polymerase II promoter; inflammatory response; positive regulation of inflammatory response; negative regulation of apoptosis