Mouse Anti-CD79a Monoclonal Antibody – Cat# MBS216236

Staining of paraffin embedded human tonsil with Mouse anti Human CD79a (MBS214376)

CD79a Antibody – Mouse Monoclonal

Name: CD79a Antibody; Monoclonal; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS216236
Price: 245 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS216236

Mouse anti Human CD79a antibody, clone HM57 recognizes an epitope within the cytoplasmic domain of CD79a. CD79a, also known as mb-1, is a 45kD protein that is expressed by B lymphocytes during differentiation from early pre-B cell stage through to plasma… More details

$245 / 0.025 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CD79a, Monoclonal Antibody

Full Product Name

MOUSE ANTI HUMAN CD79a

Product Gene Name

anti-CD79a antibody

Clonality

Monoclonal

Isotype

IgG1

Clone Number

HM57

Host

Mouse

Form/Format

Purified
Purified IgG - liquid

Concentration

IgG concentration 1.0mg/ml (lot specific)

Preparation and Storage

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Molecular Weight

20,786 Da

OMIM

112205

3D Structure

ModBase 3D Structure for P11912

Perservative Stabilisers

0.09% Sodium Azide (NaN3)
Preparation||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Histology Positive Control Tissue

Human tonsil
Buffer Solution||Phosphate buffered saline

Target Species

Human

Applications Tested/Suitable for anti-CD79a antibody

Immunohistology Frozen, Flow cytometry (FC/FACS)*, Immunohistology Paraffin*, Western Blot (WB)

Application Notes for anti-CD79a antibody

Flow Cytometry: Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
Flow Cytometry: Minimum Dilution: 1/10; Maximum Dilution: 1/50; Application Note: Membrane permeabilisation is required for this application. MyBioSource recommends the use of Leucoperm for this purpose.
Immunohistology - Paraffin: Minimum Dilution: 1/100; Maximum Dilution: 1/500; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.

Other Notes

Small volumes of anti-CD79a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD79a purchase

MBS216236 is an antibody targeting CD79a. Also known as MOUSE ANTI HUMAN CD79a. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD79a. It may not necessarily be applicable to this product.

NCBI GI #

4502685

NCBI GeneID

973

NCBI Accession #

NP_001774.1

UniProt Primary Accession #

P11912

UniProt Secondary Accession #

Q53FB8; A0N775

UniProt Related Accession #

P11912

GenBank Nucleotide #

NM_001783.3

NCBI Official Full Name

B-cell antigen receptor complex-associated protein alpha chain isoform 1

NCBI Official Synonym Full Names

CD79a molecule, immunoglobulin-associated alpha

NCBI Official Symbol

CD79A

NCBI Official Synonym Symbols

IGA; MB-1

UniProt Protein Name

B-cell antigen receptor complex-associated protein alpha chain

UniProt Synonym Protein Names

Ig-alpha; MB-1 membrane glycoprotein; Membrane-bound immunoglobulin-associated protein; Surface IgM-associated protein; CD_antigen: CD79a

Protein Family

B-cell antigen receptor complex-associated protein

UniProt Gene Name

CD79A

UniProt Synonym Gene Names

IGA; MB1

UniProt Entry Name

CD79A_HUMAN

NCBI Protein Information

B-cell antigen receptor complex-associated protein alpha chain; CD79a antigen (immunoglobulin-associated alpha); MB-1 membrane glycoprotein; ig-alpha; membrane-bound immunoglobulin-associated protein; surface IgM-associated protein

NCBI Summary for CD79a

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-alpha protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

UniProt Comments for CD79a

Ig-alpha: an integral membrane protein that associates with surface immunoglobulin B lymphocyte antigen receptor multimeric complex. Surface Ig non-covalently associates with 2 other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. Two alternatively spliced isoforms have been described.

Protein type: Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: multivesicular body; plasma membrane; integral to membrane; B cell receptor complex; lipid raft; external side of plasma membrane

Molecular Function: transmembrane receptor activity

Biological Process: B cell proliferation; B cell receptor signaling pathway; B cell activation; B cell differentiation

Disease: Agammaglobulinemia 3, Autosomal Recessive

Research Articles on CD79a

1. Phosphorylation of CD79a causes a decrease in helical propensity in the C-terminal region, for CD79b, the opposite was observed and phosphorylation resulted in an increase of helical propensity in the C-terminal part.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD79a antibody

Reference Product	PubMed Publications
CD79B antibody	>616 publications with CD79a and CD79B
CD19 antibody	>150 publications with CD79a and CD19
PTPRC antibody	>85 publications with CD79a and PTPRC
CD22 antibody	>69 publications with CD79a and CD22
SYK antibody	>36 publications with CD79a and SYK
LYN antibody	>27 publications with CD79a and LYN
BLNK antibody	>12 publications with CD79a and BLNK
FYN antibody	>10 publications with CD79a and FYN
BLK antibody	>5 publications with CD79a and BLK

Pathways associated with anti-CD79a antibody

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway antibodies	Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
BCR Signaling Pathway antibodies	BCR Signaling Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Primary Immunodeficiency Pathway antibodies	Primary Immunodeficiency Pathway Diagram
Primary Immunodeficiency Pathway antibodies	Primary Immunodeficiency Pathway Diagram
Signaling By The B Cell Receptor (BCR) Pathway antibodies	Signaling By The B Cell Receptor (BCR) Pathway Diagram

Diseases associated with anti-CD79a antibody

Disease Name	Pubmed Publications
Lymphoma Antibodies	>725 publications with CD79a and Lymphoma
Leukemia Antibodies	>267 publications with CD79a and Leukemia
Skin Neoplasms Antibodies	>85 publications with CD79a and Skin Neoplasms
Neoplasms, Experimental Antibodies	>77 publications with CD79a and Neoplasms, Experimental
Inflammation Antibodies	>45 publications with CD79a and Inflammation
Liver Diseases Antibodies	>42 publications with CD79a and Liver Diseases
Necrosis Antibodies	>40 publications with CD79a and Necrosis
Hyperplasia Antibodies	>39 publications with CD79a and Hyperplasia
Lung Diseases Antibodies	>38 publications with CD79a and Lung Diseases
Liver Neoplasms Antibodies	>29 publications with CD79a and Liver Neoplasms

Organs/Tissues associated with anti-CD79a antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>579 publications with CD79a and Blood
Lymph Node Antibodies	>226 publications with CD79a and Lymph Node
Lymph Antibodies	>211 publications with CD79a and Lymph
Spleen Antibodies	>90 publications with CD79a and Spleen
Liver Antibodies	>83 publications with CD79a and Liver
Lung Antibodies	>55 publications with CD79a and Lung
Intestine Antibodies	>45 publications with CD79a and Intestine
Thymus Antibodies	>31 publications with CD79a and Thymus
Heart Antibodies	>28 publications with CD79a and Heart
Mouth Antibodies	>22 publications with CD79a and Mouth