Published customer image: Progressive degeneration of the nigral dopaminergic neurons after intrastriatal LPS. (A) Representative TH immunostaining of coronal midbrain sections demonstrates that the numbers of TH-positive neurons and fibers in the substantia nigra pars compacta are gradually reduced by intrastriatal LPS injection. Note that TH-positive neurons in the medial substantia nigra pars compacta and ventral tegmental area are spared; scale bar: 200 um. (B) Stereological cell counts of the TH-positive neurons in the substantia nigra pars compacta (n = 5 -6/group, ** p
Published customer imageEffect of levodopa/benserazide treatment on MHC II+cells in the corpus callosum (CC) after tMCAO. (A) Number of MHC II+ cells in the CC contralateral to the lesioned hemisphere of rats treated with vehicle (n?=?7) or levodopa/benserazide (n?=?6). Data are presented as means?+/-?SEM and statistical difference was tested with the Student's t-test, P?
Published customer imageReduction of MHC II protein and pro-inflammatory cytokines 14 days after tMCAO. (A) Co-localization of MHC II (Cy3, red) and D1 receptors (Alexa 488, green) in the peri-infarct area 14 days after tMCAO; two cells are indicated with an arrow. Higher magnification of the area delineated in the merged low power micrograph. The asterisk indicates the infarct core. Scale bars: low magnification - 50 um; high magnification - 5 um. (B) Western blot analysis for MHC II in the infarct core of rats treated either with vehicle (VH, n?=?4) or levodopa/benserazide (LD, n?=?4). Levels of MHC II protein are presented as arbitrary units (AU) to the right. Data are displayed as means?+/-?SEM, Student's t-test, P?
Staining of rat spleen cells with Mouse anti H-2I-Ak/s: FITC (MBS214435)
Published customer image: Visualization of microglia in midbrain with GSA-I-B4 lectin (A-F) and in motor cortex with OX-42 (G) and OX-6 (H) during symptomatic disease. A, low power view of midbrain reveals enhanced lectin staining in the red nucleus. B, higher magnification shows that enhanced lectin reactivity is confined strictly to red nucleus region (arrows indicate perimeter of red nucleus). C, microglial fusions are interspersed with rubrospinal neurons that appear undamaged. D, lectin-positive microglial fusion (giant cell) within red nucleus. E, oculomotor nucleus reveals normal-appearing motor neurons and lack of microgliosis. F, substantia nigra (pars compacta) shows presence of normal, ramified microglial cells. G, motor cortex shows normal, ramified microglia. H, single, ramified microglial cell positive with OX-6 (arrow) near lateral ventricle. Scale bars: 400 um (A); 200 um (E); 100 um (B,H); 50 um (C,F,G); 20 um (D).From: Fendrick SE, Xue QS, Streit WJ. Formation of multinucleated giant cells and microglial degeneration in rats expressing a mutant Cu/Zn superoxide dismutase gene. J Neuroinflammation. 2007 Feb 28;4:9.
Staining of rat spleen cells with Mouse anti H-2I-Ak/s: Alexa Fluor 488
Staining of rat spleen cells with Mouse anti H-2I-Ak/s (MBS214438)
Published customer image: Activation of microglial cells. Vertical section of retinas from a SD (A-C), untreated P23H (D-F) and tauroursodeoxycholic acid (TUDCA)-treated P23H (G-I) rat stained for Iba1 (green; A, D, G) MHC-II RT 1B (red; B, E, H) or both (C, F, I). Nuclei stained with a nuclear marker (TO-PRO 3, blue). All images were collected from the central area of the retina, close to the optic nerve. GCL, ganglion cell layer; IPL, inner plexiform layer; INL, inner nuclear layer; OPL, outer plexiform layer; ONL, outer nuclear layer. Scale bar: 20 um.From: Noailles A, Fern¡ndez-S¡nchez L, Lax P, Cuenca N. Microglia activation in a model of retinal degeneration and TUDCA neuroprotective effects. J Neuroinflammation. 2014 Oct 29;11(1):186.
Published cusromer image: OX-6 IHC staining in the DG. No OX-6 positive cells were identified in P1 D1D2 pups treated with either NS (a) or Dex (b). Brain tumor implant staining as a positive control showed OX-6 positive cells stained brown (c), arrow). Magnification, 400x; scale bar, 50?um.From: Sze CI, Lin YC, Lin YJ, Hsieh TH, Kuo YM, Lin CH. The role of glucocorticoid receptors in dexamethasone-induced apoptosis of neuroprogenitor cells in the hippocampus of rat pups. Mediators Inflamm. 2013;2013:628094.
Staining of rat spleen cells with Mouse anti H-2I-Ak/s: Alexa Fluor 647
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