Neuronal Cell Adhesion Molecule (NRCAM) Antibody – Rabbit Polyclonal

Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

NRCAM: Cell adhesion, ankyrin-binding protein involved in neuron-neuron adhesion. May play a role in the molecular assembly of the nodes of Ranvier. Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion

Chromosomal Location of Human Ortholog: 7q31

Cellular Component: external side of plasma membrane; extracellular region; integral to plasma membrane; neuron projection; plasma membrane; synapse

Molecular Function: ankyrin binding; protein binding

Biological Process: action potential propagation; angiogenesis; axonal fasciculation; axonogenesis; cell-cell adhesion; central nervous system development; clustering of voltage-gated sodium channels; heterotypic cell-cell adhesion; neuron migration; positive regulation of neuron differentiation; protein localization; regulation of axon extension; retinal ganglion cell axon guidance; synaptogenesis