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CD1a Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS216613

MBS216613 is an antibody targeting CD1a. Also known as MOUSE ANTI HUMAN CD1a:RPE. Host: Mouse. More details

$290 / 25 Tests +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD1a, Monoclonal Antibody
Full Product Name
MOUSE ANTI HUMAN CD1a:RPE
Product Gene Name
anti-CD1a antibody
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
NA1/34-HLK
Host
Mouse
Form/Format
Purified IgG conjugated to R. Phycoerythrin (RPE) - lyophilised.
Preparation and Storage
Prior to reconstitution store at 4 degree C. Following reconstitution store at 4 degree C. DO NOT FREEZE. This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of reconstitution.
Molecular Weight
37,077 Da
OMIM
188370
Reconstitution
Reconstitute in 0.25 ml disilled water
Perservative Stabilisers||0.09% Sodium Azide
1.0% Bovine Serum Albumin
5% Sucrose
Preparation||Purified IgG prepared by ion exchange chromatography.
Buffer Solution
Phosphate buffered saline
Target Species
Human
Applications Tested/Suitable for anti-CD1a antibody
Flow cytometry (FC/FACS)
Application Notes for anti-CD1a antibody
Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Flow Cytometry: Maximum Dilution: Neat

Testing Data of anti-CD1a antibody

Published customer image: CLR expression on various DC subsets present in the endometrium. (a) Langerin positive cells were mainly detected within the luminal and glandular epithelium. Positive co-localization (yellow) was detected with Langerin+ cells (green) and (b) CD1a (red) and (c) CD11c (red). (d) Double-positive cells (yellow) expressing Langerin+ (green) and CD4+ (red) cells were also detected within CD4+ lymphoid aggregates. (e) DC-SIGN and (f) MR were detected in the lamina superficialis, just beneath the luminal epithelium (I: minimum distance of cell body to endometrial lumen: 49 um and 40 um, respectively). Both (g) DC-SIGN (green) and (h) MR(green) were co-expressed (yellow) on CD68+ cells (red) as well as (i and j, respectively) CD11c+ cells (red). Neither (k) DC-SIGN (red) nor (l) MR (red) were expressed on CD1a+ (green) cells. Scale bars: a: 500 um; b -d: 25 um; e -l: 100 um.From: Kaldensj¶ T, Petersson P, Tolf A, Morgan G, Broliden K, et al. (2011) Detection of Intraepithelial and Stromal Langerin and CCR5 Positive Cells in the Human Endometrium: Potential Targets for HIV Infection. PLoS ONE 6(6): e21344.
Mouse Anti-CD1a Monoclonal Antibody – Cat# MBS216613

Testing Data of anti-CD1a antibody

Immunofluorescence staining of human tonsil cryosection using Mouse anti Human CD1a antibody (MBS213166. A in red) and Mouse anti Human CD21 (MBS212051. B in green). C is the merged image. Medium power
Mouse Anti-CD1a Monoclonal Antibody, Testing Data – Cat# MBS216613

Testing Data of anti-CD1a antibody

Staining of MOLT 4 cells with Mouse anti Human CD1a:FITC (MBS211106)
Mouse Anti-CD1a Monoclonal Antibody, Testing Data – Cat# MBS216613

Testing Data of anti-CD1a antibody

Immunoperoxidase staining of human tonsil cryosection using Mouse anti Human CD1a antibody (MBS213166) followed by HISTAR detection system. High power
Mouse Anti-CD1a Monoclonal Antibody, Testing Data – Cat# MBS216613

Testing Data of anti-CD1a antibody

Immunoperoxidase staining of human tonsil cryosection using Mouse anti Human CD1a antibody (MBS213166) followed by HISTAR detection system. Low power
Mouse Anti-CD1a Monoclonal Antibody, Testing Data – Cat# MBS216613

Testing Data of anti-CD1a antibody

Immunofluorescence staining of human tonsil cryosection using Mouse anti Human CD1a antibody (MBS213166. A in red) and Mouse anti Human CD21 (MBS212051. B in green). C is the merged image. High power
Mouse Anti-CD1a Monoclonal Antibody, Testing Data – Cat# MBS216613

Testing Data of anti-CD1a antibody

Staining of MOLT 4 cells with Mouse anti Human CD1a:RPE (MBS213885)
Mouse Anti-CD1a Monoclonal Antibody, Testing Data – Cat# MBS216613

Testing Data of anti-CD1a antibody

Staining of MOLT 4 cells with Mouse anti Human CD1a (MBS213166)
Mouse Anti-CD1a Monoclonal Antibody, Testing Data – Cat# MBS216613

Testing Data of anti-CD1a antibody

Immunofluorescence staining of human tonsil cryosection using Mouse anti Human CD1a antibody (MBS213166. A in red) and Mouse anti Human CD21 (MBS212051. B in green). C is the merged image. Low power
Mouse Anti-CD1a Monoclonal Antibody, Testing Data – Cat# MBS216613

Testing Data of anti-CD1a antibody

Immunoperoxidase staining of human tonsil cryosection using Mouse anti Human CD1a antibody (MBS213166) followed by HISTAR detection system. Medium power
Mouse Anti-CD1a Monoclonal Antibody, Testing Data – Cat# MBS216613

Other Notes

Small volumes of anti-CD1a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CD1a. It may not necessarily be applicable to this product.

NCBI GI #
110618224
NCBI GeneID
909
NCBI Accession #
NP_001754.2
UniProt Secondary Accession #
Q13962; Q5TDJ8; Q9UMM4; Q9Y5M5; D3DVD7
UniProt Related Accession #
P06126
GenBank Nucleotide #
NM_001763.2
NCBI Official Full Name
T-cell surface glycoprotein CD1a
NCBI Official Synonym Full Names
CD1a molecule
NCBI Official Symbol
CD1A
NCBI Official Synonym Symbols
R4; T6; CD1; FCB6; HTA1
UniProt Protein Name
T-cell surface glycoprotein CD1a
UniProt Synonym Protein Names
T-cell surface antigen T6/Leu-6; hTa1 thymocyte antigen; CD_antigen: CD1a
Protein Family
T-cell surface glycoprotein
UniProt Gene Name
CD1A
UniProt Synonym Gene Names
hTa1 thymocyte antigen
UniProt Entry Name
CD1A_HUMAN
NCBI Protein Information
T-cell surface glycoprotein CD1a; CD1A antigen, a polypeptide; T-cell surface antigen T6/Leu-6; cluster of differentiation 1 A; cortical thymocyte antigen CD1A; differentiation antigen CD1-alpha-3; epidermal dendritic cell marker CD1a; hTa1 thymocyte antigen

NCBI Summary for CD1a

This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
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UniProt Comments for CD1a

CD1A: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q23.1

Cellular Component: integral to plasma membrane; plasma membrane; endosome membrane

Molecular Function: protein binding; beta-2-microglobulin binding; exogenous lipid antigen binding; endogenous lipid antigen binding

Biological Process: antigen processing and presentation, exogenous lipid antigen via MHC class Ib; immune response
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Research Articles on CD1a

1. A polymorphism in human CD1A is associated with susceptibility to tuberculosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD1a antibody

 Reference Product  PubMed Publications
 CD1B antibody  >151 publications with CD1a and CD1B
 CD207 antibody  >102 publications with CD1a and CD207
 CD1E antibody  >31 publications with CD1a and CD1E
 CD9 antibody  >8 publications with CD1a and CD9
 IL1B antibody  >1 publications with CD1a and IL1B
 B2M antibody  >1 publications with CD1a and B2M

Pathways associated with anti-CD1a antibody

 Products by Pathway  Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram

Diseases associated with anti-CD1a antibody

 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >372 publications with CD1a and Lung Diseases
 Necrosis Antibodies  >324 publications with CD1a and Necrosis
 Inflammation Antibodies  >209 publications with CD1a and Inflammation
 Cardiovascular Diseases Antibodies  >76 publications with CD1a and Cardiovascular Diseases
 Liver Diseases Antibodies  >66 publications with CD1a and Liver Diseases
 Fibrosis Antibodies  >57 publications with CD1a and Fibrosis
 Hyperplasia Antibodies  >57 publications with CD1a and Hyperplasia
 Death Antibodies  >56 publications with CD1a and Death
 Breast Neoplasms Antibodies  >46 publications with CD1a and Breast Neoplasms
 Lung Neoplasms Antibodies  >45 publications with CD1a and Lung Neoplasms

Organs/Tissues associated with anti-CD1a antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1534 publications with CD1a and Blood
 Skin Antibodies  >912 publications with CD1a and Skin
 Lymph Node Antibodies  >281 publications with CD1a and Lymph Node
 Lung Antibodies  >165 publications with CD1a and Lung
 Thymus Antibodies  >118 publications with CD1a and Thymus
 Brain Antibodies  >57 publications with CD1a and Brain
 Heart Antibodies  >30 publications with CD1a and Heart
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