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Plasminogen Activator, Urokinase Receptor (uPAR) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2166700

MBS2166700 is an antibody targeting uPAR. Also known as Cy3-Linked Monoclonal Antibody to Plasminogen Activator, Urokinase Receptor (uPAR). Reactive in Rat, Mouse. Host: Mouse. More details

$345 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Plasminogen Activator, Urokinase Receptor (uPAR), Monoclonal Antibody
Full Product Name
Cy3-Linked Monoclonal Antibody to Plasminogen Activator, Urokinase Receptor (uPAR)
Product Gene Name
anti-uPAR antibody
Product Synonym Names
Plasminogen Activator, Urokinase Receptor; CD87; PLAUR; PLAU-R; U-PAR; URKR; Monocyte Activation Antigen Mo3
Immunogen Sequence
Thr17~Asn2 12
Clonality
Monoclonal
Clone Number
2#
Host
Mouse
Species Reactivity
Rat, Mouse
Form/Format
Liquid; 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Purity/Purification
Protein A + Protein G affinity chromatography
Concentration
>=1mg/mL (Please refer to the vial label for the specific concentration.) (lot specific)
Preparation and Storage
Store at 2 degree C to 8 degree C for frequent use, -20 degree C for 12 months
Matching Pairs
Cy3 Conjugated Antibody: uPAR Clone #2# (MBS2166700)
Immunogen: uPAR (MBS2009643)
Matching Pairs
Unconjugated Antibody: uPAR Clone #2# (MBS2170162)
Cy3 Conjugated Antibody: uPAR Clone #2# (MBS2166700)
Molecular Weight
24,417 Da
3D Structure
ModBase 3D Structure for P49616
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Conjugation
Cy3

Product Categories/Family for anti-uPAR antibody

Monoclonal Antibodies (Primary Abs); Primary, Cy3-conjugated; Tumor immunity; Hematology
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-uPAR antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
Application Notes for anti-uPAR antibody
WB: 0.2-2ug/mL
IHC: 5-20ug/mL
ICC: 5-20ug/mL

Other Notes

Small volumes of anti-uPAR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for uPAR. It may not necessarily be applicable to this product.

NCBI GI #
8394516
NCBI GeneID
50692
NCBI Accession #
NP_059046.1
UniProt Primary Accession #
P49616
UniProt Secondary Accession #
O35771; P51573; Q7TN35
UniProt Related Accession #
P49616
GenBank Nucleotide #
NM_017350.1
NCBI Official Full Name
urokinase plasminogen activator surface receptor isoform 2
NCBI Official Synonym Full Names
plasminogen activator, urokinase receptor
NCBI Official Symbol
Plaur
NCBI Official Synonym Symbols
Par; uPAR; Plaur3; uPAR-2; uPAR-3
UniProt Protein Name
Urokinase plasminogen activator surface receptor
UniProt Synonym Protein Names
CD_antigen: CD87
UniProt Gene Name
Plaur
UniProt Synonym Gene Names
U-PAR; uPAR
NCBI Protein Information
urokinase plasminogen activator surface receptor

NCBI Summary for uPAR

receptor for urokinase-plasminogen activator; may play a central role in malignant tumour progression [RGD, Feb 2006]

UniProt Comments for uPAR

uPAR: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. Monomer (Probable). Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2. Expressed in neurons of the rolandic area of the brain. Expressed in the brain. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, GPI anchor; Motility/polarity/chemotaxis; Receptor, misc.

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: cell surface; extracellular region; focal adhesion; integral component of plasma membrane; plasma membrane

Molecular Function: enzyme binding; protein domain specific binding; receptor binding; U-plasminogen activator receptor activity

Biological Process: mesenchymal cell differentiation; negative regulation of apoptosis; positive regulation of DNA binding; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of protein phosphorylation; regulation of proteolysis; skeletal muscle tissue regeneration; spermatogenesis
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Research Articles on uPAR

1. Increased postmortem PLAUR expression could serve as a biomarker to aid diagnosis of early myocardial infarction.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-uPAR antibody

 Reference Product  PubMed Publications
 Serpine1 antibody  >25 publications with uPAR and Serpine1
 Plau antibody  >22 publications with uPAR and Plau
 Plg antibody  >14 publications with uPAR and Plg
 Pigs antibody  >11 publications with uPAR and Pigs
 Hrg antibody  >2 publications with uPAR and Hrg
 Serpinb2 antibody  >2 publications with uPAR and Serpinb2

Pathways associated with anti-uPAR antibody

 Products by Pathway  Pathway Diagram
 Attachment Of GPI Anchor To UPAR Pathway antibodies  Attachment Of GPI Anchor To UPAR Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Dissolution Of Fibrin Clot Pathway antibodies  Dissolution Of Fibrin Clot Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Neutrophil Degranulation Pathway antibodies  Neutrophil Degranulation Pathway Diagram

Diseases associated with anti-uPAR antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >316 publications with uPAR and Carcinoma
 Neoplasm Invasiveness Antibodies  >263 publications with uPAR and Neoplasm Invasiveness
 Neoplasm Metastasis Antibodies  >241 publications with uPAR and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >165 publications with uPAR and Breast Neoplasms
 Inflammation Antibodies  >129 publications with uPAR and Inflammation
 Lung Diseases Antibodies  >94 publications with uPAR and Lung Diseases
 Cardiovascular Diseases Antibodies  >92 publications with uPAR and Cardiovascular Diseases
 Lung Neoplasms Antibodies  >76 publications with uPAR and Lung Neoplasms
 Disease Models, Animal Antibodies  >73 publications with uPAR and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >73 publications with uPAR and Neoplasms, Experimental

Organs/Tissues associated with anti-uPAR antibody

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >66 publications with uPAR and Prostate
 Connective Tissue Antibodies  >34 publications with uPAR and Connective Tissue
 Placenta Antibodies  >29 publications with uPAR and Placenta
 Heart Antibodies  >22 publications with uPAR and Heart
 Pancreas Antibodies  >9 publications with uPAR and Pancreas
 Thymus Antibodies  >4 publications with uPAR and Thymus
 Uncharacterized Tissue Antibodies  >1 publications with uPAR and Uncharacterized Tissue
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