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Mannosidase Alpha Class 1a Member 1 (MAN1A1) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2168608

MBS2168608 is an antibody targeting MAN1A1. Also known as FITC-Linked Monoclonal Antibody to Mannosidase Alpha Class 1A Member 1 (MAN1A1). Reactive in Human. Host: Mouse. More details

$275 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Mannosidase Alpha Class 1A Member 1 (MAN1A1), Monoclonal Antibody
Full Product Name
FITC-Linked Monoclonal Antibody to Mannosidase Alpha Class 1A Member 1 (MAN1A1)
Product Gene Name
anti-MAN1A1 antibody
Product Synonym Names
Mannosidase Alpha Class 1A Member 1; HUMM3; HUMM9; MAN9; Mannosyl-Oligosaccharide 1,2-Alpha-Mannosidase IA; Mannosidase alpha class 1A member 1; Processing alpha-1,2-mannosidase IA
Immunogen Sequence
Ile322~Glu 653
Clonality
Monoclonal
Isotype
IgG1 Kappa
Clone Number
C8
Host
Mouse
Species Reactivity
Human
Form/Format
Liquid; 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Purity/Purification
Protein A + Protein G affinity chromatography
Concentration
>=1mg/mL (Please refer to the vial label for the specific concentration.) (lot specific)
Preparation and Storage
Store at 2 degree C to 8 degree C for frequent use, -20 degree C for 12 months
Matching Pairs
FITC Conjugated Antibody: MAN1A1 Clone #C8 (MBS2168608)
Immunogen: MAN1A1 (MBS2034114)
Matching Pairs
Unconjugated Antibody: MAN1A1 Clone #C8 (MBS2169471)
FITC Conjugated Antibody: MAN1A1 Clone #C8 (MBS2168608)
Molecular Weight
72,969 Da
OMIM
604344
3D Structure
ModBase 3D Structure for P33908
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Conjugation
FITC

Product Categories/Family for anti-MAN1A1 antibody

Monoclonal Antibodies (Primary Abs); Primary, FITC-conjugated; Enzyme & Kinase
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-MAN1A1 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
Application Notes for anti-MAN1A1 antibody
WB: 0.01-2ug/mL
IHC: 5-20ug/mL
ICC: 5-20ug/mL

Other Notes

Small volumes of anti-MAN1A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MAN1A1. It may not necessarily be applicable to this product.

NCBI GI #
62906886
NCBI GeneID
4121
NCBI Accession #
P33908.3
UniProt Primary Accession #
P33908
UniProt Secondary Accession #
Q9NU44; Q9UJI3
UniProt Related Accession #
P33908
NCBI Official Full Name
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA
NCBI Official Synonym Full Names
mannosidase, alpha, class 1A, member 1
NCBI Official Symbol
MAN1A1
NCBI Official Synonym Symbols
MAN9; HUMM3; HUMM9
UniProt Protein Name
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA
UniProt Synonym Protein Names
Man(9)-alpha-mannosidase; Man9-mannosidase; Mannosidase alpha class 1A member 1; Processing alpha-1,2-mannosidase IA
Protein Family
Mannosyl-oligosaccharide 1,2-alpha-mannosidase
UniProt Gene Name
MAN1A1
UniProt Synonym Gene Names
Man9-mannosidase
UniProt Entry Name
MA1A1_HUMAN
NCBI Protein Information
mannosyl-oligosaccharide 1,2-alpha-mannosidase IA; Man9-mannosidase; alpha-1,2-mannosidase IA; man(9)-alpha-mannosidase; processing alpha-1,2-mannosidase IA

NCBI Summary for MAN1A1

This gene encodes a class I mammalian Golgi 1,2-mannosidase which is a type II transmembrane protein. This protein catalyzes the hydrolysis of three terminal mannose residues from peptide-bound Man(9)-GlcNAc(2) oligosaccharides and belongs to family 47 of glycosyl hydrolases. [provided by RefSeq, Jul 2012]
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UniProt Comments for MAN1A1

MAN1A1: Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2). Belongs to the glycosyl hydrolase 47 family.

Protein type: Endoplasmic reticulum; Calcium-binding; EC 3.2.1.113; Glycan Metabolism - N-glycan biosynthesis; Membrane protein, integral; Hydrolase

Chromosomal Location of Human Ortholog: 6q22

Cellular Component: Golgi membrane; Golgi apparatus; membrane; endoplasmic reticulum; cytoplasm; ER-Golgi intermediate compartment; integral to membrane

Molecular Function: mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; calcium ion binding; mannosidase activity

Biological Process: cellular protein metabolic process; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification
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Research Articles on MAN1A1

1. Complex N-glycans generated by enzymes such as a-mannosidase I inhibit the activation of naive T cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-MAN1A1 antibody

 Products by Pathway  Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 N-Glycan Biosynthesis Pathway antibodies  N-Glycan Biosynthesis Pathway Diagram
 N-Glycan Biosynthesis Pathway antibodies  N-Glycan Biosynthesis Pathway Diagram
 N-glycan Precursor Trimming Pathway antibodies  N-glycan Precursor Trimming Pathway Diagram
 N-glycan Precursor Trimming Pathway antibodies  N-glycan Precursor Trimming Pathway Diagram
 N-glycan Trimming And Elongation In The Cis-Golgi Pathway antibodies  N-glycan Trimming And Elongation In The Cis-Golgi Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Progressive Trimming Of Alpha-1,2-linked Mannose Residues From Man9/8/7GlcNAc2 To Produce Man5GlcNAc2 Pathway antibodies  Progressive Trimming Of Alpha-1,2-linked Mannose Residues From Man9/8/7GlcNAc2 To Produce Man5GlcNAc2 Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram

Diseases associated with anti-MAN1A1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2 publications with MAN1A1 and Neoplasms
 Skin Diseases Antibodies  >1 publications with MAN1A1 and Skin Diseases
 Breast Neoplasms Antibodies  >1 publications with MAN1A1 and Breast Neoplasms

Organs/Tissues associated with anti-MAN1A1 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >1 publications with MAN1A1 and Kidney
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