Mouse Anti-CYR61 Monoclonal Antibody – Cat# MBS2170163

Western Blot; Sample: MDA-MB-231 cell lysatePrimary Ab: 0.5ug/ml Mouse Anti-Human CYR61 AntibodySecond Ab: 0.2ug/ml HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody #MBS2086035

Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) Antibody – Mouse Monoclonal

Name: CYR61 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS2170163
Price: 215 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2170163

MBS2170163 is an antibody targeting CYR61. Also known as Monoclonal Antibody to Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61). Reactive in Human. Host: Mouse. More details

$215 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61), Monoclonal Antibody

Full Product Name

Monoclonal Antibody to Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61)

Product Gene Name

anti-CYR61 antibody

Product Synonym Names

Cysteine Rich Protein, Angiogenic Inducer 61; Monoclonal Antibody to Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61); CCN1; GIG1; IGFBP10; CCN family member 1; Insulin-like growth factor-binding protein 10

Immunogen Sequence

Leu178~Asp 381

Clonality

Monoclonal

Isotype

IgG

Clone Number

C10

Host

Mouse

Species Reactivity

Human

Form/Format

Liquid; PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.

Purity/Purification

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

Concentration

1mg/mL (lot specific)

Specificity

The antibody is a mouse monoclonal antibody raised against CYR61. It has been selected for its ability to recognize CYR61 in immunohistochemical staining and western blotting.

Preparation and Storage

Store at 4 degree C for frequent use. Store at -20 degree C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Matching Pairs

Unconjugated Antibody: CYR61 Clone #C10 (MBS2170163)
Immunogen: CYR61 (MBS2018603)

Matching Pairs

Unconjugated Antibody: CYR61 Clone #C10 (MBS2170163)
APC-CY7 Conjugated Antibody: CYR61 Clone #C10 (MBS2164102)

Molecular Weight

381

OMIM

602369

3D Structure

ModBase 3D Structure for O00622

Supply Chain Verification

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Conjugation

Unconjugated

Research Area

Tumor immunity

Product Categories/Family for anti-CYR61 antibody

Monoclonal Antibodies (Primary Abs)

ISO Certification

Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.

Applications Tested/Suitable for anti-CYR61 antibody

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Application Notes for anti-CYR61 antibody

WB: 0.2-2ug/mL
IHC: 5-20ug/mL
ICC: 5-20ug/mL

Other Notes

Small volumes of anti-CYR61 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CYR61. It may not necessarily be applicable to this product.

NCBI GI #

3023601

NCBI GeneID

3491

NCBI Accession #

O00622.1

UniProt Primary Accession #

O00622

UniProt Secondary Accession #

O14934; O43775; Q9BZL7

UniProt Related Accession #

O00622

NCBI Official Full Name

Protein CYR61

NCBI Official Synonym Full Names

cysteine-rich, angiogenic inducer, 61

NCBI Official Symbol

CYR61

NCBI Official Synonym Symbols

CCN1; GIG1; IGFBP10

UniProt Protein Name

Protein CYR61

UniProt Synonym Protein Names

CCN family member 1; Cysteine-rich angiogenic inducer 61; Insulin-like growth factor-binding protein 10; IBP-10; IGF-binding protein 10; IGFBP-10; Protein GIG1

Protein Family

Protein

UniProt Gene Name

CYR61

UniProt Synonym Gene Names

CCN1; GIG1; IGFBP10; IBP-10; IGF-binding protein 10; IGFBP-10

UniProt Entry Name

CYR61_HUMAN

NCBI Protein Information

protein CYR61; IBP-10; IGFBP-10; CCN family member 1; IGF-binding protein 10; cysteine-rich, anigogenic inducer, 61; cysteine-rich heparin-binding protein 61; insulin-like growth factor-binding protein 10

NCBI Summary for CYR61

The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]

UniProt Comments for CYR61

CYR61: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. Belongs to the CCN family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1p22.3

Cellular Component: extracellular matrix; proteinaceous extracellular matrix

Molecular Function: heparin binding; integrin binding; insulin-like growth factor binding; extracellular matrix binding

Biological Process: anatomical structure morphogenesis; extracellular matrix organization and biogenesis; positive regulation of caspase activity; chemotaxis; intussusceptive angiogenesis; osteoblast differentiation; positive regulation of osteoblast differentiation; cell proliferation; cell-cell signaling; positive regulation of protein kinase activity; positive regulation of osteoblast proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; regulation of cell growth; cell adhesion; positive regulation of BMP signaling pathway; negative regulation of apoptosis; positive regulation of cell migration

Research Articles on CYR61

1. integrin alpha(v) beta(3) and AMP-Activated Protein Kinases mediate CCN1-induced endothelial cell migration and tube formation independent of intracellular ATP levels alteration.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CYR61 antibody

Reference Product	PubMed Publications
JUN antibody	>85 publications with CYR61 and JUN
FOS antibody	>19 publications with CYR61 and FOS
CTNNB1 antibody	>12 publications with CYR61 and CTNNB1
SRF antibody	>5 publications with CYR61 and SRF
MKL1 antibody	>4 publications with CYR61 and MKL1
ITGB2 antibody	>1 publications with CYR61 and ITGB2
ITGAV antibody	>1 publications with CYR61 and ITGAV

Pathways associated with anti-CYR61 antibody

Products by Pathway	Pathway Diagram
Hypertrophy Model Pathway antibodies	Hypertrophy Model Pathway Diagram
Oncostatin M Signaling Pathway antibodies	Oncostatin M Signaling Pathway Diagram
Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway antibodies	Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway Diagram
RhoA Signaling Pathway antibodies	RhoA Signaling Pathway Diagram
Amb2 Integrin Signaling Pathway antibodies	Amb2 Integrin Signaling Pathway Diagram

Diseases associated with anti-CYR61 antibody

Disease Name	Pubmed Publications
Carcinoma Antibodies	>81 publications with CYR61 and Carcinoma
Inflammation Antibodies	>51 publications with CYR61 and Inflammation
Disease Models, Animal Antibodies	>44 publications with CYR61 and Disease Models, Animal
Breast Neoplasms Antibodies	>39 publications with CYR61 and Breast Neoplasms
Neoplasm Metastasis Antibodies	>39 publications with CYR61 and Neoplasm Metastasis
Fibrosis Antibodies	>36 publications with CYR61 and Fibrosis
Nervous System Diseases Antibodies	>29 publications with CYR61 and Nervous System Diseases
Necrosis Antibodies	>25 publications with CYR61 and Necrosis
Brain Diseases Antibodies	>22 publications with CYR61 and Brain Diseases
Neoplasms, Experimental Antibodies	>22 publications with CYR61 and Neoplasms, Experimental

Organs/Tissues associated with anti-CYR61 antibody

Organ/Tissue Name	Pubmed Publications
Connective Tissue Antibodies	>177 publications with CYR61 and Connective Tissue
Vascular Antibodies	>126 publications with CYR61 and Vascular
Bone Antibodies	>76 publications with CYR61 and Bone
Muscle Antibodies	>75 publications with CYR61 and Muscle
Embryonic Tissue Antibodies	>53 publications with CYR61 and Embryonic Tissue
Lung Antibodies	>47 publications with CYR61 and Lung
Brain Antibodies	>38 publications with CYR61 and Brain
Prostate Antibodies	>31 publications with CYR61 and Prostate
Skin Antibodies	>29 publications with CYR61 and Skin
Kidney Antibodies	>27 publications with CYR61 and Kidney