SOS1 Antibody – Mouse Monoclonal

This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq, Jul 2008]

SOS1: a guanine nucleotide exchange factor that activates Ras by catalyzing the exchange of bound GDP for GTP. Interacts with GRB2, NCK, and other adapter proteins. Plays an important role in signaling pathways leading from the G-protein- coupled receptors and receptor tyrosine kinases to MAPK/ERK.

Protein type: GEFs; GEFs, Ras; Motility/polarity/chemotaxis; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: cell soma; postsynaptic density; plasma membrane; cytosol

Molecular Function: protein binding; Rho guanyl-nucleotide exchange factor activity; DNA binding; protein heterodimerization activity; SH3 domain binding; Ras guanyl-nucleotide exchange factor activity

Biological Process: epidermal growth factor receptor signaling pathway; platelet activation; axon guidance; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; signal transduction; positive regulation of small GTPase mediated signal transduction; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; positive regulation of epidermal growth factor receptor signaling pathway; Ras protein signal transduction; insulin receptor signaling pathway; innate immune response; blood coagulation; leukocyte migration

Disease: Fibromatosis, Gingival, 1; Noonan Syndrome 4