Mouse Anti-CD279 Monoclonal Antibody – Cat# MBS219116

Western blot analysis of CD279 expression in cell lysates probed with Mouse anti human CD279, clone 4F12

CD279 Antibody – Mouse Monoclonal

Name: CD279 Antibody; Monoclonal; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS219116
Price: 560 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS219116

Mouse anti Human CD279, clone 4F12 recognizes human CD279, otherwise known as PD-1/PDCD1, a type I transmembrane glycoprotein and member of the Ig superfamily, which acts as a co-stimulatory molecule and negative regulator of T-cell activation (Patsoukis et… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

CD279, Monoclonal Antibody

Full Product Name

MOUSE ANTI HUMAN CD279

Product Gene Name

anti-CD279 antibody

Clonality

Monoclonal

Isotype

IgG2b

Clone Number

4F12

Host

Mouse

Form/Format

Purified
Purified IgG - liquid

Concentration

IgG concentration 1.0 mg/ml (lot specific)

Preparation and Storage

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Molecular Weight

31,647 Da

OMIM

109100

3D Structure

ModBase 3D Structure for Q15116

Perservative Stabilisers

0.1% Sodium Azide (NaN3)
Preparation||Purified IgG prepared by affinity chromatography on Protein G

Immunogen

Recombinant human CD279 (amino acids 21-167) purified from Escherichia coli.
Buffer Solution||Phosphate buffered saline

Target Species

Human

Applications Tested/Suitable for anti-CD279 antibody

ELISA (EIA), Western Blot (WB)

Application Notes for anti-CD279 antibody

Western Blot: This item detects a band of approximately 32-36 kDa in 293T and U937 cell lysates.
Western Blotting: Minimum Dilution: 1/500; Maximum Dilution: 1/1000

Other Notes

Small volumes of anti-CD279 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD279 purchase

MBS219116 is an antibody targeting CD279. Also known as MOUSE ANTI HUMAN CD279. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD279. It may not necessarily be applicable to this product.

NCBI GI #

167857792

NCBI GeneID

5133

NCBI Accession #

NP_005009.2

UniProt Primary Accession #

Q15116

UniProt Secondary Accession #

O00517; Q8IX89

UniProt Related Accession #

Q15116

GenBank Nucleotide #

NM_005018.2

NCBI Official Full Name

programmed cell death protein 1

NCBI Official Synonym Full Names

programmed cell death 1

NCBI Official Symbol

PDCD1

NCBI Official Synonym Symbols

PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1

UniProt Protein Name

Programmed cell death protein 1

UniProt Synonym Protein Names

CD_antigen: CD279

Protein Family

Programmed cell death protein

UniProt Gene Name

PDCD1

UniProt Synonym Gene Names

PD1; Protein PD-1; hPD-1

UniProt Entry Name

PDCD1_HUMAN

NCBI Protein Information

programmed cell death protein 1; protein PD-1; systemic lupus erythematosus susceptibility 2

NCBI Summary for CD279

This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]

UniProt Comments for CD279

PDCD1: a single-pass type I membrane protein. A negative regulator of activated T cells, is upregulated in human and mouse 'exhausted' T cells during persistent viral infection. A marker of angioimmunoblastic T-cell lymphoma and germinal center associated T cells.

Protein type: Membrane protein, integral; Apoptosis

Chromosomal Location of Human Ortholog: 2q37.3

Cellular Component: integral to membrane; plasma membrane; external side of plasma membrane

Molecular Function: signal transducer activity; protein binding

Biological Process: apoptosis; multicellular organismal development; T cell costimulation; signal transduction; humoral immune response

Disease: Systemic Lupus Erythematosus

Research Articles on CD279

1. These data strongly support testing of PD-1-blocking agents in combination with standard-of-care chemoradiotherapy for papillomavirus (HPV)-related oropharyngeal cancer .

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD279 antibody

Reference Product	PubMed Publications
CD4 antibody	>418 publications with CD279 and CD4
CD274 antibody	>336 publications with CD279 and CD274
PDCD1LG2 antibody	>99 publications with CD279 and PDCD1LG2
PTPN6 antibody	>7 publications with CD279 and PTPN6
PTPN11 antibody	>7 publications with CD279 and PTPN11
HLA-DR4 antibody	>1 publications with CD279 and HLA-DR4

Pathways associated with anti-CD279 antibody

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Costimulation By The CD28 Family Pathway antibodies	Costimulation By The CD28 Family Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
PD-1 Signaling Pathway antibodies	PD-1 Signaling Pathway Diagram
T Cell Receptor Signaling Pathway antibodies	T Cell Receptor Signaling Pathway Diagram
T Cell Receptor Signaling Pathway antibodies	T Cell Receptor Signaling Pathway Diagram

Diseases associated with anti-CD279 antibody

Disease Name	Pubmed Publications
Liver Diseases Antibodies	>147 publications with CD279 and Liver Diseases
Inflammation Antibodies	>115 publications with CD279 and Inflammation
Melanoma Antibodies	>79 publications with CD279 and Melanoma
Necrosis Antibodies	>75 publications with CD279 and Necrosis
Lupus Erythematosus, Systemic Antibodies	>72 publications with CD279 and Lupus Erythematosus, Systemic
Lung Diseases Antibodies	>58 publications with CD279 and Lung Diseases
Lung Neoplasms Antibodies	>38 publications with CD279 and Lung Neoplasms
Adenocarcinoma Antibodies	>35 publications with CD279 and Adenocarcinoma
Kidney Diseases Antibodies	>28 publications with CD279 and Kidney Diseases
Liver Neoplasms Antibodies	>26 publications with CD279 and Liver Neoplasms

Organs/Tissues associated with anti-CD279 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>945 publications with CD279 and Blood
Kidney Antibodies	>36 publications with CD279 and Kidney