Growth Differentiation Factor 2 (GDF2) ELISA Kit for Human

Name: Human GDF2 ELISA Kit; Growth Differentiation Factor 2; MyBioSource
Brand: MyBioSource
SKU: MBS021947
Price: 675 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS021947

Introduction: ELISA is a simple and highly sensitive method of analysis that allows for simultaneous and rapid quantification of a large number of samples. The assay is based on the specific recognition of the target compound (analyte/antigen) by antibodies… More details

$675 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

Growth Differentiation Factor 2 (GDF2), ELISA Kit

Full Product Name

Human Growth Differentiation Factor 2 ELISA Kit

Product Gene Name

GDF2 elisa kit

Species Reactivity

Human

Assay Type

Sandwich

Samples

Serum, Plasma, Tissue Homogenate, Feces, Urine and Body Fluids

Detection Range

3.12 pg/ml – 100 pg/ml.

Sensitivity

1.0 pg/ml.

Specificity

No significant cross-reactivity or interference between Human GDF2 and analogues was observed.

Preparation and Storage

Store all reagents at 2-8 degree C

Inter-assay Precision

Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean x100]

Intra-assay Precision

Intra-assay CV (%) is less than 15%.

Molecular Weight

47,320 Da

Chromosome Location

Chromosome: 10; NC_000010.10 (48413092..48416853, complement). Location: 10q11.22

OMIM

605120

3D Structure

ModBase 3D Structure for Q9UK05

Intended Uses

ELISA is a simple and highly sensitive method of analysis that allows for simultaneous and rapid quantification of a large number of samples. The assay is based on the specific recognition of the target compound (analyte/antigen) by antibodies which bind to the compound. The antigen-antibody complex is detected and measured with the aid of an enzyme-labeled antibody or antigen. Upon addition of a non-colored reagent, the enzyme produces a color reaction where the color intensity is directly or inversely proportional to the concentration of the analyte in the sample. This quantitative Sandwich ELISA kit is in tended to determinate GDF2 concentrations in Human serum, plasma, tissue homogenates, feces, urine and body fluids, and it is only for research, not for drug, household, therapeutic applications

Other Notes

Small volumes of GDF2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GDF2 purchase

MBS021947 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Growth Differentiation Factor 2 (GDF2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing GDF2. The ELISA analytical biochemical technique of the MBS021947 kit is based on GDF2 antibody-GDF2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GDF2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GDF2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for GDF2. It may not necessarily be applicable to this product.

NCBI GI #

7705308

NCBI GeneID

2658

NCBI Accession #

NP_057288.1

UniProt Primary Accession #

Q9UK05

UniProt Secondary Accession #

Q5VSQ9; Q9Y571

UniProt Related Accession #

Q9UK05

GenBank Nucleotide #

NM_016204.1

NCBI Official Full Name

growth/differentiation factor 2

NCBI Official Synonym Full Names

growth differentiation factor 2

NCBI Official Symbol

GDF2

NCBI Official Synonym Symbols

BMP9; BMP-9

UniProt Protein Name

Growth/differentiation factor 2

UniProt Synonym Protein Names

Bone morphogenetic protein 9

Protein Family

Growth/differentiation factor

UniProt Gene Name

GDF2

UniProt Synonym Gene Names

BMP9; GDF-2; BMP-9

UniProt Entry Name

GDF2_HUMAN

NCBI Protein Information

growth/differentiation factor 2; GDF-2; bone morphogenetic protein 9

NCBI Summary for GDF2

The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein plays a role in the adult liver and in differentiation of cholinergic central nervous system neurons. [provided by RefSeq, Jul 2008]

UniProt Comments for GDF2

GDF2: Could be involved in bone formation. Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 10q11.22

Cellular Component: extracellular space

Molecular Function: protein binding; growth factor activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: cellular iron ion homeostasis; positive regulation of transcription, DNA-dependent; activin receptor signaling pathway; regulation of apoptosis; positive regulation of interleukin-8 production; BMP signaling pathway; positive regulation of endothelial cell differentiation; angiogenesis; vasculogenesis; positive regulation of BMP signaling pathway; ossification; negative regulation of blood vessel endothelial cell migration; osteoblast differentiation; patterning of blood vessels; positive regulation of osteoblast differentiation; negative regulation of angiogenesis; positive regulation of angiogenesis; negative regulation of DNA replication; cartilage development; regulation of MAPKKK cascade; negative regulation of endothelial cell proliferation; blood vessel morphogenesis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of endothelial cell proliferation; negative regulation of cell growth; cell development; growth

Disease: Telangiectasia, Hereditary Hemorrhagic, Type 5

Research Articles on GDF2

1. the enhanced expression of BMP-9 in osteosarcoma cells by adBMP-9 exerted inhibitory effects on growth and migration of osteosarcoma cells possibly via blockade of the PI3K/AKT signaling pathway.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GDF2 elisa kit

Reference Product	PubMed Publications
ACVRL1 elisa kit	>15 publications with GDF2 and ACVRL1
BMPR2 elisa kit	>13 publications with GDF2 and BMPR2
ENG elisa kit	>10 publications with GDF2 and ENG
SMAD5 elisa kit	>4 publications with GDF2 and SMAD5
HEY1 elisa kit	>3 publications with GDF2 and HEY1
CHAT elisa kit	>2 publications with GDF2 and CHAT
HAMP elisa kit	>1 publications with GDF2 and HAMP
SMAD9 elisa kit	>1 publications with GDF2 and SMAD9

Pathways associated with GDF2 elisa kit

Products by Pathway	Pathway Diagram
ALK1 Signaling Events Pathway antibodies	ALK1 Signaling Events Pathway Diagram

Diseases associated with GDF2 elisa kit

Disease Name	Pubmed Publications
Neoplasms Antibodies	>6 publications with GDF2 and Neoplasms
Congenital Abnormalities Antibodies	>4 publications with GDF2 and Congenital Abnormalities
Disease Models, Animal Antibodies	>3 publications with GDF2 and Disease Models, Animal
Lung Diseases Antibodies	>1 publications with GDF2 and Lung Diseases
Drug Toxicity Antibodies	>1 publications with GDF2 and Drug Toxicity
Intestinal Diseases Antibodies	>1 publications with GDF2 and Intestinal Diseases
Inflammation Antibodies	>1 publications with GDF2 and Inflammation

Organs/Tissues associated with GDF2 elisa kit

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>6 publications with GDF2 and Liver