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Tropomodulin 1 (TMOD1) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS219480

MBS219480 specifically recognises an epitope between amino acid residues 6-57 within the N-terminal (NT) region of Tropomodulin 1 (Tmod1), otherwise known as erythrocyte tropomodulin (E-Tmod). Tmod1 is a sarcomeric protein highly expressed by erythrocytes,… More details

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Product Overview

Product Name
TROPOMODULIN 1 (TMOD1), Monoclonal Antibody
Full Product Name
MOUSE ANTI TROPOMODULIN 1 (N-TERMINAL)
Product Gene Name
anti-TMOD1 antibody
Clonality
Monoclonal
Isotype
IgG1
Clone Number
TRM-17 (Mab17)
Host
Mouse
Species Reactivity
Birds, Fish (Expected from Sequence), Insect (Expected from Sequence), Mammals, Reptile (Expected from Sequence)
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 1.0 mg/ml (lot specific)
Specificity
This item specifically recognises an epitope between amino acid residues 6-57 within the N-terminal (NT) region of Tropomodulin 1 (Tmod1), otherwise known as erythrocyte tropomodulin (E-Tmod). Tmod1 is a sarcomeric protein highly expressed by erythrocytes, heart and skeletal muscle, which binds to and caps pointed ends of actin filaments to prevent thin filament elongation. The binding of the N-terminal region of Tmod1 with the actin-binding protein tropomyosin blocks the elongation and depolymerization of actin filaments, contributing to the geometry of the membrane skeleton. Clone TRM-17 functionally inhibits the binding of Tmod1 to tropomyosin.
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Molecular Weight
26,014 Da
OMIM
190930
Perservative Stabilisers
0.05% Sodium Azide (NaN3)
Preparation||Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
Immunogen
Recombinant chicken E-Tmod
Buffer Solution||Phosphate buffered saline
Target Species
Chicken
Applications Tested/Suitable for anti-TMOD1 antibody
ELISA (EIA), Functional Assays (FN)*, Immunofluorescence (IF), Western Blot (WB)
Application Notes for anti-TMOD1 antibody
Western Blot: This item detects a band of approximately 40kDa in chick heart lysates.
Functional Assays: Application Note: Removal of sodium azide is recommended prior to use in functional assays.

Other Notes

Small volumes of anti-TMOD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TMOD1 purchase

MBS219480 is an antibody targeting TMOD1. Also known as MOUSE ANTI TROPOMODULIN 1 (N-TERMINAL). Reactive in Birds, Fish (Expected from Sequence), Insect (Expected from Sequence), Mammals, Reptile (Expected from Sequence). Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for TMOD1. It may not necessarily be applicable to this product.

NCBI GI #
12803651
NCBI GeneID
7111
NCBI Accession #
AAH02660.1
UniProt Secondary Accession #
Q5T7W3; Q9BUF1; B2RB77
UniProt Related Accession #
P28289
NCBI Official Full Name
Tropomodulin 1
NCBI Official Synonym Full Names
tropomodulin 1
NCBI Official Symbol
TMOD1
NCBI Official Synonym Symbols
TMOD; ETMOD; D9S57E
UniProt Protein Name
Tropomodulin-1
UniProt Synonym Protein Names
Erythrocyte tropomodulin; E-Tmod
Protein Family
Tropomodulin
UniProt Gene Name
TMOD1
UniProt Synonym Gene Names
D9S57E; TMOD; E-Tmod
UniProt Entry Name
TMOD1_HUMAN
NCBI Protein Information
tropomodulin-1; E-Tmod; e-tropomodulin; erythrocyte tropomodulin

NCBI Summary for TMOD1

This gene encodes a member of the tropomodulin family. The encoded protein is an actin-capping protein that regulates tropomyosin by binding to its N-terminus, inhibiting depolymerization and elongation of the pointed end of actin filaments and thereby influencing the structure of the erythrocyte membrane skeleton. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]
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UniProt Comments for TMOD1

TMOD1: Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus. Belongs to the tropomodulin family.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal; Contractile; Cell development/differentiation

Chromosomal Location of Human Ortholog: 9q22.3

Cellular Component: signalosome; cortical cytoskeleton; membrane; cytosol; striated muscle thin filament

Molecular Function: actin filament binding; tropomyosin binding

Biological Process: myofibril assembly; muscle contraction; adult locomotory behavior; actin filament organization; pointed-end actin filament capping; muscle filament sliding
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Research Articles on TMOD1

1. The structures and biochemical analysis of structure-inspired mutants showed that one Tmod molecule interacts with three actin subunits at the pointed end, while also contacting two tropomyosin molecules on each side of the filament.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TMOD1 antibody

 Reference Product  PubMed Publications
 TPM3 antibody  >55 publications with TMOD1 and TPM3
 TPM1 antibody  >3 publications with TMOD1 and TPM1
 TNNT2 antibody  >1 publications with TMOD1 and TNNT2
 TTN antibody  >1 publications with TMOD1 and TTN

Pathways associated with anti-TMOD1 antibody

 Products by Pathway  Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
 Striated Muscle Contraction Pathway antibodies  Striated Muscle Contraction Pathway Diagram
 Striated Muscle Contraction Pathway antibodies  Striated Muscle Contraction Pathway Diagram

Diseases associated with anti-TMOD1 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >12 publications with TMOD1 and Cardiovascular Diseases
 Heart Diseases Antibodies  >11 publications with TMOD1 and Heart Diseases
 Hypertrophy Antibodies  >4 publications with TMOD1 and Hypertrophy
 Disease Models, Animal Antibodies  >3 publications with TMOD1 and Disease Models, Animal
 Heart Defects, Congenital Antibodies  >1 publications with TMOD1 and Heart Defects, Congenital
 Memory Disorders Antibodies  >1 publications with TMOD1 and Memory Disorders
 Fetal Death Antibodies  >1 publications with TMOD1 and Fetal Death
 Weight Loss Antibodies  >1 publications with TMOD1 and Weight Loss
 Learning Disorders Antibodies  >1 publications with TMOD1 and Learning Disorders
 Inflammation Antibodies  >1 publications with TMOD1 and Inflammation

Organs/Tissues associated with anti-TMOD1 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >57 publications with TMOD1 and Muscle
 Heart Antibodies  >26 publications with TMOD1 and Heart
 Embryonic Tissue Antibodies  >12 publications with TMOD1 and Embryonic Tissue
 Eye Antibodies  >10 publications with TMOD1 and Eye
 Brain Antibodies  >10 publications with TMOD1 and Brain
 Liver Antibodies  >4 publications with TMOD1 and Liver
 Kidney Antibodies  >3 publications with TMOD1 and Kidney
 Intestine Antibodies  >2 publications with TMOD1 and Intestine
 Ganglia Antibodies  >2 publications with TMOD1 and Ganglia
 Lung Antibodies  >2 publications with TMOD1 and Lung
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