P2X7 Antibody – Rat Monoclonal

P2X7: a receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis by macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Alternatively spliced variants encoding different isoforms have been identified. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. Phosphorylation results in its inactivation.

Protein type: Channel, ligand-gated; Membrane protein, multi-pass; Receptor, misc.; Membrane protein, integral

Cellular Component: cell soma; membrane; integral to plasma membrane; integral to membrane; plasma membrane; synapse; integral to nuclear inner membrane; intercellular junction; intracellular; cytosol; neuromuscular junction; external side of plasma membrane

Molecular Function: protein binding; channel activity; lipopolysaccharide binding; ion channel activity; receptor activity; purinergic nucleotide receptor activity; ATP binding; ATP-gated cation channel activity

Biological Process: positive regulation of catalytic activity; positive regulation of apoptosis; positive regulation of T cell mediated cytotoxicity; activation of MAPK activity; cytolysis; positive regulation of glutamate secretion; programmed cell death; response to lipopolysaccharide; positive regulation of interleukin-1 beta secretion; sensory perception of pain; response to organic cyclic substance; protein amino acid phosphorylation; positive regulation of interleukin-1 alpha secretion; multicellular organismal protein catabolic process; ceramide biosynthetic process; T cell homeostasis; response to electrical stimulus; positive regulation of gamma-aminobutyric acid secretion; response to drug; mitochondrion organization and biogenesis; collagen metabolic process; positive regulation of interleukin-6 production; protein oligomerization; phospholipid translocation; phagolysosome formation; membrane depolarization; defense response to Gram-positive bacterium; response to bacterium; NAD transport; positive regulation of protein secretion; response to zinc ion; response to mechanical stimulus; response to calcium ion; cell volume homeostasis; phospholipid transfer to membrane; cell morphogenesis; T cell proliferation; response to organic substance; positive regulation of mitochondrial depolarization; positive regulation of MAPKKK cascade; plasma membrane organization and biogenesis; transport; calcium ion transport; pore complex biogenesis; inflammatory response; negative regulation of bone resorption; cation transport; negative regulation of MAPKKK cascade; membrane protein ectodomain proteolysis; bleb formation; positive regulation of bone mineralization; response to ATP; positive regulation of ossification; positive regulation of interleukin-1 beta production; synaptic vesicle exocytosis; skeletal morphogenesis; homeostasis of number of cells within a tissue; release of sequestered calcium ion into cytosol; positive regulation of prostaglandin secretion; cellular response to extracellular stimulus; gene expression; protein processing; ion transport; positive regulation of protein amino acid phosphorylation; membrane budding; positive regulation of cytokine secretion