ABCA1 Antibody – Rat Monoclonal

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. In humans, this protein functions as a cholesterol efflux pump in the cellular lipid removal pathway. Mutations in the human gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008]

ABCA1: an ATP-binding cassette (ABC) transporter that regulates cholesterol homeostasis and insulin secretion in beta-cells, and protects against cardiovascular disease. Inactivation of ABCA1 in beta-cells markedly impairs glucose tolerance and insulin secretion in mice. Rosiglitazone, an activator of the peroxisome proliferator-activated receptor-gamma, upregulates ABCA1 in beta-cells. ABCA1 expression in beta-cells is required for the beneficial effects of rosiglitazone on glucose tolerance. Mediates the transport of cholesterol and phospholipids from cells to HDL apolipoproteins, modulating HDL levels and atherogenesis. Induced by bacterial lipopolysaccharides (LPS) and repressed by ZNF202. Phosphorylation on Ser-2054 regulates phospholipid efflux. Unsaturated fatty acids destabilize ABCA1 by activating a PKC-delta pathway that phosphorylates ABCA1 serines. Defects in ABCA1 are a cause of high density lipoprotein deficiencies.

Protein type: Membrane protein, multi-pass; Transporter; Membrane protein, integral; Transporter, ABC family; Vesicle

Cellular Component: Golgi apparatus; cell surface; membrane; intracellular membrane-bound organelle; endocytic vesicle; perinuclear region of cytoplasm; integral to plasma membrane; plasma membrane; integral to membrane; phagocytic vesicle; lipid raft; external side of plasma membrane

Molecular Function: apolipoprotein A-I receptor activity; transporter activity; ATPase activity; nucleotide binding; apolipoprotein binding; ATPase binding; small GTPase binding; apolipoprotein A-I binding; protein binding; syntaxin binding; phospholipid transporter activity; ATPase activity, coupled to transmembrane movement of substances; cholesterol transporter activity; anion transmembrane transporter activity; ATP binding; receptor binding

Biological Process: endosome transport; phospholipid efflux; platelet dense granule organization and biogenesis; transport; positive regulation of cAMP biosynthetic process; protein amino acid lipidation; interleukin-1 beta secretion; transmembrane transport; peptide secretion; phospholipid homeostasis; cholesterol metabolic process; regulation of Cdc42 protein signal transduction; cholesterol transport; response to high density lipoprotein stimulus; lipoprotein metabolic process; cholesterol efflux; intracellular cholesterol transport; phospholipid translocation; G-protein coupled receptor protein signaling pathway; cholesterol homeostasis; reverse cholesterol transport; lipoprotein biosynthetic process; lysosome organization and biogenesis; phospholipid transport; phagocytosis, engulfment