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IFN GAMMA (IFNG) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS220076

MBS220076 recognizes chicken Interferon gamma (chIFN-gamma). Original studies investigating the properties of chicken Interferon (chIFN), revealed properties similar to mammalian IFN type I (IFNI), and it has since become apparent that there are at least… More details

$760 / 0.5 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IFN GAMMA (IFNG), Polyclonal Antibody
Full Product Name
RABBIT ANTI CHICKEN INTERFERON GAMMA:Preservative Free
Product Gene Name
anti-IFNG antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Form/Format
Preservative Free
Purified IgG - liquid
Concentration
IgG concentration 0.5 mg/ml (lot specific)
Specificity
This item recognizes chicken Interferon gamma (chIFN-gamma). Original studies investigating the properties of chicken Interferon (chIFN), revealed properties similar to mammalian IFN type I (IFNI), and it has since become apparent that there are at least three distinct chicken interferon proteins, designated as chIFN-alpha, chIFN-beta and chIFN-gamma. chIFN-gamma was first identified, when supernatant from chicken spleen cells stimulated with concanavalin A (ConA), displayed macrophage-activating factor (MAF) activity - the principle function of mammalian type II IFN-gamma. Several independent studies have since supported the existence of this chicken homolog, by the cloning of IFN-gamma cDNA from activated chicken T cells and demonstrating that recombinant chicken IFN-gamma strongly upregulates the expression of MHC class II and iNOS genes. This item, can be used to neutralize chIFN-gamma activity and to discriminate the antiviral activity of chIFN-gamma from that of chIFN-alpha and chIFN-beta, see Weining, K.C. et al. for details.
Preparation and Storage
Store at -20 degree C only. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Molecular Weight
18,953 Da
3D Structure
ModBase 3D Structure for P49708
Immunogen
Recombinant chicken Interferon Gamma
Buffer Solution||Phosphate buffered saline
Antiserum Preparation
Antisera to chicken Interferon Gamma were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography on protein G.
Target Species
Chicken
Applications Tested/Suitable for anti-IFNG antibody
ELISA (EIA), Functional Assays (FN), Western Blot (WB)
Application Notes for anti-IFNG antibody
Western Blot: This item detects a band of approximately 18 kDa.

Other Notes

Small volumes of anti-IFNG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IFNG purchase

MBS220076 is an antibody targeting IFNG. Also known as RABBIT ANTI CHICKEN INTERFERON GAMMA:Preservative Free. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IFNG. It may not necessarily be applicable to this product.

NCBI GI #
45433518
NCBI GeneID
396054
NCBI Accession #
NP_990480.1
UniProt Primary Accession #
P49708
UniProt Secondary Accession #
Q53YS2; D3GGX1
UniProt Related Accession #
P49708
GenBank Nucleotide #
NM_205149.1
NCBI Official Full Name
interferon gamma
NCBI Official Synonym Full Names
interferon, gamma
NCBI Official Symbol
IFNG
UniProt Protein Name
Interferon gamma
Protein Family
Interferon
UniProt Gene Name
IFNG
UniProt Synonym Gene Names
IFN-gamma
UniProt Entry Name
IFNG_CHICK
NCBI Protein Information
interferon gamma; IFN-gamma; Interferon-gamma level; interferon-gama

UniProt Comments for IFNG

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons ().
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Research Articles on IFNG

1. Vitiligo in Smyth line chickens appears to be a Th1-polarized autoimmune disease, whereby IFN-gamma expression is strongly associated with parallel increases in IL-10 and IL-21, particularly during the early and active stages of vitiligo.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-IFNG antibody

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Proteasome Pathway antibodies  Proteasome Pathway Diagram
 Proteasome Pathway antibodies  Proteasome Pathway Diagram

Diseases associated with anti-IFNG antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >155 publications with IFNG and Necrosis
 Autoimmune Diseases Antibodies  >90 publications with IFNG and Autoimmune Diseases
 Respiratory Tract Diseases Antibodies  >71 publications with IFNG and Respiratory Tract Diseases
 Hepatitis Antibodies  >34 publications with IFNG and Hepatitis
 Lymphoproliferative Disorders Antibodies  >21 publications with IFNG and Lymphoproliferative Disorders
 Diabetes Mellitus, Type 1 Antibodies  >17 publications with IFNG and Diabetes Mellitus, Type 1
 HIV Infections Antibodies  >17 publications with IFNG and HIV Infections
 Hepatitis C Antibodies  >16 publications with IFNG and Hepatitis C
 Arthritis, Rheumatoid Antibodies  >15 publications with IFNG and Arthritis, Rheumatoid
 Leishmaniasis Antibodies  >11 publications with IFNG and Leishmaniasis

Organs/Tissues associated with anti-IFNG antibody

 Organ/Tissue Name  Pubmed Publications
 Other Antibodies  >177 publications with IFNG and Other
 Ovary Antibodies  >15 publications with IFNG and Ovary
 Thyroid Antibodies  >2 publications with IFNG and Thyroid
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