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G-CSF Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS220159

Rabbit anti Human G-CSF antibody recognizes human G-CSF (Granulocyte colony-stimulating factor), a 19.6kDa haematopoietic growth factor and member of the CSF family of hormone-like glycoproteins, which stimulates the development of bone marrow progenitor… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
G-CSF, Polyclonal Antibody
Full Product Name
RABBIT ANTI HUMAN G-CSF:Biotin
Product Gene Name
anti-G-CSF antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Form/Format
Biotin
Purified IgG conjugated to Biotin - lyophilised
Concentration
IgG concentration 0.1 mg/ml after reconstitution. (lot specific)
Preparation and Storage
Prior to reconstitution store at 4 degree C. After reconstitution store at -20 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of reconstitution.
Molecular Weight
18,434 Da
OMIM
138970
3D Structure
ModBase 3D Structure for P09919
Reconstitution
Reconstitute with 0.5ml sterile PBS containing 0.1% Bovine Serum Albumin. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution. For long term storage the addition of 0.09% sodium azide is recommended.
Immunogen
Recombinant human G-CSF
Buffer Solution||Phosphate buffered saline
Antiserum Preparation
Antisera to human G-CSF were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Target Species
Human
Applications Tested/Suitable for anti-G-CSF antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-G-CSF antibody
ELISA: This biotinylated human G-CSF antibody may be used in a direct ELISA or as the detection reagent in a sandwich ELISA with our purified human G-CSF antibody as the capture reagent and recombinant human G-CSF as the standard.
ELISA: Minimum Dilution: 0.25; Maximum Dilution: 1.0ug/ml
Western Blotting: Minimum Dilution: 0.1; Maximum Dilution: 0.2ug/ml

Testing Data #1 of anti-G-CSF antibody

Staining of formalin fixed, paraffin embedded human angiosarcoma with Rabbit anti Human G-CSF (MBS221336) following heat mediated antigen retrieval using sodium citrate buffer (pH6.0)
Rabbit Anti-G-CSF Polyclonal Antibody – Cat# MBS220159

Testing Data #2 of anti-G-CSF antibody

Staining of formalin fixed, paraffin embedded human angiosarcoma with Rabbit anti Human G-CSF (MBS221336) following heat mediated antigen retrieval using sodium citrate buffer (pH6.0)
Rabbit Anti-G-CSF Polyclonal Antibody, Testing Data #2 – Cat# MBS220159

Other Notes

Small volumes of anti-G-CSF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for G-CSF purchase

MBS220159 is an antibody targeting G-CSF. Also known as RABBIT ANTI HUMAN G-CSF:Biotin. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for G-CSF. It may not necessarily be applicable to this product.

NCBI GI #
4503079
NCBI GeneID
1440
NCBI Accession #
NP_000750.1
UniProt Primary Accession #
P09919
UniProt Secondary Accession #
A8MXR7
UniProt Related Accession #
P09919
GenBank Nucleotide #
NM_000759.3
NCBI Official Full Name
granulocyte colony-stimulating factor isoform a
NCBI Official Synonym Full Names
colony stimulating factor 3 (granulocyte)
NCBI Official Symbol
CSF3
NCBI Official Synonym Symbols
GCSF; CSF3OS; C17orf33
UniProt Protein Name
Granulocyte colony-stimulating factor
UniProt Synonym Protein Names
Pluripoietin; INN: Filgrastim; INN: Lenograstim
Protein Family
Granulocyte colony-stimulating factor receptor
UniProt Gene Name
CSF3
UniProt Synonym Gene Names
C17orf33; GCSF; G-CSF
UniProt Entry Name
CSF3_HUMAN
NCBI Protein Information
granulocyte colony-stimulating factor; filgrastim; granulocyte-colony stimulating factor; lenograstim; pluripoietin

NCBI Summary for G-CSF

The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]

UniProt Comments for G-CSF

G-CSF: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes. Belongs to the IL-6 superfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Secreted, signal peptide; Secreted; Cell cycle regulation

Chromosomal Location of Human Ortholog: 17q11.2-q12

Cellular Component: extracellular space

Molecular Function: enzyme binding; growth factor activity; cytokine activity; granulocyte colony-stimulating factor receptor binding

Biological Process: positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein binding; positive regulation of actin filament polymerization; positive regulation of myeloid cell differentiation; granulocyte differentiation; cytokine and chemokine mediated signaling pathway; multicellular organismal development; positive regulation of cell proliferation; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; immune response; positive regulation of peptidyl-serine phosphorylation
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Research Articles on G-CSF

1. G-CSF constrains cancer to grow and progress by, respectively, supporting the survival of sympathetic nerve fibers in 6-hydroxydopamine-sympathectomized mice.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-G-CSF antibody

 Reference Product  PubMed Publications
 CSF3R antibody  >14 publications with G-CSF and CSF3R
 MMP9 antibody  >7 publications with G-CSF and MMP9
 IL10 antibody  >6 publications with G-CSF and IL10
 CXCL12 antibody  >4 publications with G-CSF and CXCL12
 ERBB2 antibody  >2 publications with G-CSF and ERBB2
 STAT3 antibody  >2 publications with G-CSF and STAT3
 SELL antibody  >1 publications with G-CSF and SELL
 CXCR4 antibody  >1 publications with G-CSF and CXCR4

Pathways associated with anti-G-CSF antibody

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response Pathway antibodies  Cytokines And Inflammatory Response Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram

Diseases associated with anti-G-CSF antibody

 Disease Name  Pubmed Publications
 Disease Susceptibility Antibodies  >6 publications with G-CSF and Disease Susceptibility
 Nervous System Diseases Antibodies  >5 publications with G-CSF and Nervous System Diseases
 Breast Neoplasms Antibodies  >3 publications with G-CSF and Breast Neoplasms
 Neutropenia Antibodies  >3 publications with G-CSF and Neutropenia
 Leukopenia Antibodies  >2 publications with G-CSF and Leukopenia
 Anemia Antibodies  >2 publications with G-CSF and Anemia
 Neoplasm Metastasis Antibodies  >2 publications with G-CSF and Neoplasm Metastasis
 Leukemia, Myeloid, Acute Antibodies  >2 publications with G-CSF and Leukemia, Myeloid, Acute
 Peripheral Nervous System Diseases Antibodies  >1 publications with G-CSF and Peripheral Nervous System Diseases
 Pulmonary Fibrosis Antibodies  >1 publications with G-CSF and Pulmonary Fibrosis

Organs/Tissues associated with anti-G-CSF antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >7 publications with G-CSF and Skin
 Muscle Antibodies  >5 publications with G-CSF and Muscle
 Lung Antibodies  >5 publications with G-CSF and Lung
 Brain Antibodies  >3 publications with G-CSF and Brain
 Liver Antibodies  >2 publications with G-CSF and Liver
 Uterus Antibodies  >2 publications with G-CSF and Uterus
 Uncharacterized Tissue Antibodies  >1 publications with G-CSF and Uncharacterized Tissue
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