GRIA1 Antibody – Rabbit Polyclonal

GluR1: an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. Expressed in granule and pyramidal cells in the hippocampal formation.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, ligand-gated; Channel, calcium

Cellular Component: endoplasmic reticulum membrane; neuron projection; cell surface; protein complex; endoplasmic reticulum; dendrite; early endosome; postsynaptic density; dendritic spine; integral to membrane; excitatory synapse; cytosol; asymmetric synapse; postsynaptic membrane; recycling endosome; synaptic vesicle; membrane; cell soma; plasma membrane; ionotropic glutamate receptor complex; synapse; dendritic shaft; cell junction; neuromuscular junction

Molecular Function: identical protein binding; protein domain specific binding; protein homodimerization activity; myosin V binding; G-protein beta-subunit binding; G-protein alpha-subunit binding; protein kinase binding; PDZ domain binding; small GTPase binding; protein binding; extracellular-glutamate-gated ion channel activity; ionotropic glutamate receptor activity; beta-2 adrenergic receptor binding; protein kinase A binding; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; adenylate cyclase binding

Biological Process: regulation of synaptic transmission; response to drug; synaptic transmission, glutamatergic; response to peptide hormone stimulus; response to toxin; response to arsenic; response to lithium ion; generation of action potential; regulation of synaptic plasticity; response to cocaine; response to organic cyclic substance; positive regulation of synaptic transmission; response to estradiol stimulus; synaptic transmission; long-term memory; ionotropic glutamate receptor signaling pathway; spinal cord development; receptor internalization; regulation of receptor recycling; response to electrical stimulus; positive regulation of membrane potential