G PROTEIN ALPHA 0 (GNAO1) Antibody – Rabbit Polyclonal

G-alpha(o): Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14. Interacts with RGS14. G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Belongs to the G-alpha family. G(i/o/t/z) subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: G protein; G protein, heterotrimeric alpha G((i/o/t/z)); G protein, heterotrimeric

Cellular Component: neuron projection; protein complex; membrane; dendrite; plasma membrane; heterotrimeric G-protein complex; intracellular; myelin sheath

Molecular Function: GTPase activity; corticotropin-releasing hormone receptor 1 binding; GTP binding; guanyl nucleotide binding; metal ion binding; nucleotide binding; GTPase activating protein binding; signal transducer activity; protein binding; mu-type opioid receptor binding; G-protein beta/gamma-subunit binding; protein complex binding; metabotropic serotonin receptor binding

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein coupled receptor protein signaling pathway; negative regulation of calcium ion transport; metabolic process; dopamine receptor signaling pathway; locomotory behavior; signal transduction; response to organic nitrogen; cellular process; regulation of heart contraction; positive regulation of GTPase activity; aging