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GRO BETA/MIP-2 (CXCL2) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS221290

Rabbit anti Rat GRO beta/MIP-2 antibody recognizes rat GRO beta/MIP-2, also known CXCL2, an 8kD chemokine which promotes neutrophil chemotaxis and degranulation and is expressed by monocytes, fibroblasts, endothelial cells, synovial cell and several tumour… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
GRO BETA/MIP-2 (Cxcl2), Polyclonal Antibody
Full Product Name
RABBIT ANTI RAT GRO BETA/MIP-2
Product Gene Name
anti-Cxcl2 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Form/Format
Purified
Purified IgG - lyophilised
Concentration
IgG concentration 1.0 mg/ml (lot specific)
Preparation and Storage
Prior to reconstitution store at 4 degree C. Following reconstitution store at -20 degree C. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of reconstitution.
Molecular Weight
10,783 Da
3D Structure
ModBase 3D Structure for P30348
Reconstitution
Reconstitute with 0.1 ml distilled water. The addition of 0.09% sodium azide is recommended for long term storage.N.B. For functional studies do not add sodium azide.
Immunogen
Recombinant rat GRO beta/MIP-2
Buffer Solution||Phosphate buffered saline
Antiserum Preparation
Antisera to rat GRO beta/MIP-2 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Target Species
Rat
Applications Tested/Suitable for anti-Cxcl2 antibody
ELISA (EIA), Functional Assays (FN), Western Blot (WB)
Application Notes for anti-Cxcl2 antibody
ELISA: Maximum Dilution: 0.5ug/ml;
Functional Assays: Minimum Dilution: 3.0ug/ml; Maximum Dilution: 5.0ug/ml;
Western Blotting: Minimum Dilution: 0.1ug/ml; Maximum Dilution: 0.2ug/ml

Other Notes

Small volumes of anti-Cxcl2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Cxcl2 purchase

MBS221290 is an antibody targeting Cxcl2. Also known as RABBIT ANTI RAT GRO BETA/MIP-2. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Cxcl2. It may not necessarily be applicable to this product.

NCBI GI #
16758460
NCBI GeneID
114105
NCBI Accession #
NP_446099.1
UniProt Primary Accession #
P30348
UniProt Secondary Accession #
Q5WA60
UniProt Related Accession #
P30348
GenBank Nucleotide #
NM_053647.1
NCBI Official Full Name
C-X-C motif chemokine 2
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 2
NCBI Official Symbol
Cxcl2
NCBI Official Synonym Symbols
Mip-2; Scyb2
UniProt Protein Name
C-X-C motif chemokine 2
UniProt Synonym Protein Names
Cytokine-induced neutrophil chemoattractant 3; CINC-3; Macrophage inflammatory protein 2; MIP2
Protein Family
C-X-C motif chemokine
UniProt Gene Name
Cxcl2
UniProt Synonym Gene Names
Cinc3; Mip-2; Mip2; Scyb2; CINC-3; MIP2
UniProt Entry Name
CXCL2_RAT
NCBI Protein Information
C-X-C motif chemokine 2; CINC-3; MIP2; cytokine-induced neutrophil chemoattractant 3; macrophage inflammatory protein 2; small inducible cytokine subfamily, member 2

NCBI Summary for Cxcl2

chemokine involved in the pulmonary inflammatory response [RGD, Feb 2006]

UniProt Comments for Cxcl2

CXCL3: Ligand for CXCR2. Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted

Cellular Component: extracellular space

Molecular Function: chemokine activity; CXCR chemokine receptor binding

Biological Process: neutrophil chemotaxis; wound healing; leukocyte chemotaxis; response to amphetamine; response to glucocorticoid stimulus; positive regulation of leukocyte chemotaxis; response to estradiol stimulus; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; response to heat; response to molecule of bacterial origin; response to gamma radiation; immune response; inflammatory response
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Research Articles on Cxcl2

1. IL-1beta-mediated regulation of the CXCL1 and CXCL2 genes in pancreatic beta-cells requires stimulus-induced changes in histone chemical modifications, recruitment of the NF-kappaB and STAT1 transcription factors to genomic regulatory sequences within the proximal gene promoters, and increases in phosphorylated forms of RNA polymerase II.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Cxcl2 antibody

 Reference Product  PubMed Publications
 Cxcl1 antibody  >569 publications with Cxcl2 and Cxcl1
 Ccl2 antibody  >380 publications with Cxcl2 and Ccl2
 Il8rb antibody  >121 publications with Cxcl2 and Il8rb
 Cxcl3 antibody  >100 publications with Cxcl2 and Cxcl3
 Cxcr4 antibody  >44 publications with Cxcl2 and Cxcr4
 Ccr2 antibody  >42 publications with Cxcl2 and Ccr2
 Cxcl6 antibody  >37 publications with Cxcl2 and Cxcl6
 Ccr1 antibody  >26 publications with Cxcl2 and Ccr1
 Cxcr3 antibody  >18 publications with Cxcl2 and Cxcr3
 Ppbp antibody  >3 publications with Cxcl2 and Ppbp

Pathways associated with anti-Cxcl2 antibody

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram

Diseases associated with anti-Cxcl2 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1032 publications with Cxcl2 and Inflammation
 Necrosis Antibodies  >652 publications with Cxcl2 and Necrosis
 Lung Diseases Antibodies  >390 publications with Cxcl2 and Lung Diseases
 Disease Models, Animal Antibodies  >365 publications with Cxcl2 and Disease Models, Animal
 Lung Injury Antibodies  >264 publications with Cxcl2 and Lung Injury
 Pneumonia Antibodies  >175 publications with Cxcl2 and Pneumonia
 Reperfusion Injury Antibodies  >115 publications with Cxcl2 and Reperfusion Injury
 Wounds and Injuries Antibodies  >98 publications with Cxcl2 and Wounds and Injuries
 Edema Antibodies  >95 publications with Cxcl2 and Edema
 Skin Diseases Antibodies  >84 publications with Cxcl2 and Skin Diseases

Organs/Tissues associated with anti-Cxcl2 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >636 publications with Cxcl2 and Lung
 Connective Tissue Antibodies  >28 publications with Cxcl2 and Connective Tissue
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