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CD193 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS221319

Rabbit anti Human CD193 antibody recognizes human CD193, otherwise known as CC chemokine receptor 3 (CCR3), a seven-helix transmembrane G-protein coupled receptor which, along with CCR5 and CXCR4, acts as a principal receptor for the fusion and entry of HIV… More details

$670 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CD193, Polyclonal Antibody
Full Product Name
RABBIT ANTI HUMAN CD193
Product Gene Name
anti-CD193 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse, Rat
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 0.5mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Molecular Weight
43,453 Da
OMIM
601268
3D Structure
ModBase 3D Structure for P51677
Perservative Stabilisers
0.02% Sodium Azide (NaN3)
Histology Positive Control Tissue
Human spleen.
Buffer Solution||Phosphate buffered saline
Antiserum Preparation
Antisera to human CD193 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Target Species
Human
Applications Tested/Suitable for anti-CD193 antibody
Immunohistology Frozen, Immunofluorescence (IF), Immunohistology Paraffin*, Western Blot (WB)
Application Notes for anti-CD193 antibody
Western Blot: This item detects a band of approximately 55kDa in human spleen cell lysates (predicted Mwt. 41kDa)
Immunohistology - Paraffin: Maximum Dilution: 10ug/ml; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
Western Blotting: Maximum Dilution: 1ug/ml

Testing Data #1 of anti-CD193 antibody

Western blot analysis on normal human spleen lysate probed with Rabbit anti Human CD193 (MBS221319)
Rabbit Anti-CD193 Polyclonal Antibody – Cat# MBS221319

Testing Data #2 of anti-CD193 antibody

Formalin fixed, paraffin embedded normal human spleen stained with Rabbit anti Human CD193 (MBS221319) following heat mediated antigen retrieval using sodium citrate buffer (pH6.0)
Rabbit Anti-CD193 Polyclonal Antibody, Testing Data #2 – Cat# MBS221319

Other Notes

Small volumes of anti-CD193 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD193 purchase

MBS221319 is an antibody targeting CD193. Also known as RABBIT ANTI HUMAN CD193. Reactive in Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CD193. It may not necessarily be applicable to this product.

NCBI GI #
4502637
NCBI GeneID
1232
NCBI Accession #
NP_001828.1
UniProt Primary Accession #
P51677
UniProt Secondary Accession #
Q15748; Q2YDB9; Q86WD2; Q8TDP6; Q9ULY8; B3KVQ1; F5GWL6
UniProt Related Accession #
P51677
GenBank Nucleotide #
NM_001837.3
NCBI Official Full Name
C-C chemokine receptor type 3 isoform 1
NCBI Official Synonym Full Names
chemokine (C-C motif) receptor 3
NCBI Official Symbol
CCR3
NCBI Official Synonym Symbols
CKR3; CD193; CMKBR3; CC-CKR-3
UniProt Protein Name
C-C chemokine receptor type 3
UniProt Synonym Protein Names
Eosinophil eotaxin receptor; CD_antigen: CD193
Protein Family
C-C chemokine receptor
UniProt Gene Name
CCR3
UniProt Synonym Gene Names
CMKBR3; C-C CKR-3; CC-CKR-3; CCR-3; CCR3; CKR3
UniProt Entry Name
CCR3_HUMAN
NCBI Protein Information
C-C chemokine receptor type 3; C-C CKR-3; CC chemokine receptor 3; CCR-3; b-chemokine receptor; eosinophil CC chemokine receptor 3; eosinophil eotaxin receptor

NCBI Summary for CD193

The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]
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UniProt Comments for CD193

CCR3: Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Motility/polarity/chemotaxis; Membrane protein, multi-pass; Receptor, cytokine; GPCR, family 1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding; C-C chemokine receptor activity; chemokine receptor activity

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; elevation of cytosolic calcium ion concentration; positive regulation of angiogenesis; viral reproduction; cellular defense response; positive regulation of endothelial cell proliferation; cell adhesion; inflammatory response; chemotaxis
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Research Articles on CD193

1. In vitro chemotaxis assay indicates dominant role of RANTES and IP-10 in the selective recruitment of CXCR3(+)CCR5(+)cells at the tubercular pathologic sites.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD193 antibody

 Reference Product  PubMed Publications
 CCL11 antibody  >333 publications with CD193 and CCL11
 CCL5 antibody  >195 publications with CD193 and CCL5
 CCL24 antibody  >99 publications with CD193 and CCL24
 CCL3 antibody  >68 publications with CD193 and CCL3
 CCL26 antibody  >67 publications with CD193 and CCL26
 CXCL10 antibody  >47 publications with CD193 and CXCL10
 CCL7 antibody  >43 publications with CD193 and CCL7
 CCL13 antibody  >32 publications with CD193 and CCL13
 CXCL9 antibody  >29 publications with CD193 and CXCL9
 CXCL11 antibody  >10 publications with CD193 and CXCL11

Pathways associated with anti-CD193 antibody

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram

Diseases associated with anti-CD193 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >366 publications with CD193 and Inflammation
 Asthma Antibodies  >247 publications with CD193 and Asthma
 Lung Diseases Antibodies  >201 publications with CD193 and Lung Diseases
 Respiratory Hypersensitivity Antibodies  >175 publications with CD193 and Respiratory Hypersensitivity
 HIV Infections Antibodies  >123 publications with CD193 and HIV Infections
 Necrosis Antibodies  >82 publications with CD193 and Necrosis
 Dermatitis, Atopic Antibodies  >43 publications with CD193 and Dermatitis, Atopic
 Gastrointestinal Diseases Antibodies  >39 publications with CD193 and Gastrointestinal Diseases
 Cardiovascular Diseases Antibodies  >32 publications with CD193 and Cardiovascular Diseases
 Arthritis, Rheumatoid Antibodies  >27 publications with CD193 and Arthritis, Rheumatoid

Organs/Tissues associated with anti-CD193 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >841 publications with CD193 and Blood
 Connective Tissue Antibodies  >14 publications with CD193 and Connective Tissue
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