Rabbit Anti-MIP-1 BETA Polyclonal Antibody – Cat# MBS221343

Formalin fixed, paraffin embedded human pancreatic adenocarcinoma stained with Rabbit anti human MIP-1β (MBS221343) following heat mediated antigen retrieval using sodium citrate buffer (pH6.0)

MIP-1 BETA Antibody – Rabbit Polyclonal

Name: MIP-1 BETA Antibody; Polyclonal; Rabbit; MyBioSource
Brand: MyBioSource
SKU: MBS221343
Price: 710 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS221343

Rabbit anti Human MIP-1 beta antibody recognizes human MIP-1 beta, otherwise known as CCL4, a 69 amino acid member of the CC chemokine family, shown to signal through the chemokine receptors CCR1, CCR2 and CCR5. MIP-1 beta is involved in host defence against… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

MIP-1 BETA, Polyclonal Antibody

Full Product Name

RABBIT ANTI HUMAN MIP-1 BETA

Product Gene Name

anti-MIP-1 BETA antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Form/Format

Purified
Purified IgG - lyophilised

Concentration

IgG concentration 1.0mg/ml (lot specific)

Preparation and Storage

Prior to reconstitution store at 4 degree C. After reconstitution store at -20 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of reconstitution.

Molecular Weight

10,212 Da

OMIM

182284

3D Structure

ModBase 3D Structure for P13236

Reconstitution

Reconstitute with 0.1ml distilled water. For long term storage the addition of 0.09% sodium azide is recommended. NB: For functional studies do not add azide.

Immunogen

Recombinant human MIP-1 beta.
Buffer Solution||Phosphate buffered saline

Antiserum Preparation

Antisera to human MIP-1 beta were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.

Target Species

Human

Applications Tested/Suitable for anti-MIP-1 BETA antibody

ELISA (EIA), Functional Assays (FN), Immunohistology Paraffin*, Western Blot (WB)

Application Notes for anti-MIP-1 BETA antibody

ELISA: Maximum Dilution: 0.5ug/ml;
Functional Assays: Minimum Dilution: 1.75; Maximum Dilution: 3.0ug/ml;
Immunohistology - Paraffin: Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.

Western Blotting: Minimum Dilution: 0.1; Maximum Dilution: 0.2ug/ml

Other Notes

Small volumes of anti-MIP-1 BETA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MIP-1 BETA purchase

MBS221343 is an antibody targeting MIP-1 BETA. Also known as RABBIT ANTI HUMAN MIP-1 BETA. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MIP-1 BETA. It may not necessarily be applicable to this product.

NCBI GI #

4506845

NCBI GeneID

6351

NCBI Accession #

NP_002975.1

UniProt Primary Accession #

P13236

UniProt Secondary Accession #

P22617; Q13704; Q3SXL8; Q6FGI8

UniProt Related Accession #

P13236

GenBank Nucleotide #

NM_002984.3

NCBI Official Full Name

C-C motif chemokine 4

NCBI Official Synonym Full Names

chemokine (C-C motif) ligand 4

NCBI Official Symbol

CCL4

NCBI Official Synonym Symbols

ACT2; G-26; HC21; LAG1; LAG-1; MIP1B; SCYA2; SCYA4; MIP1B1; AT744.1; MIP-1-beta

UniProt Protein Name

C-C motif chemokine 4

UniProt Synonym Protein Names

G-26 T-lymphocyte-secreted protein; HC21; Lymphocyte activation gene 1 protein; LAG-1; MIP-1-beta(1-69); Macrophage inflammatory protein 1-beta; MIP-1-beta; PAT 744; Protein H400; SIS-gamma; Small-inducible cytokine A4; T-cell activation protein 2; ACT-2

Protein Family

C-C motif chemokine

UniProt Gene Name

CCL4

UniProt Synonym Gene Names

LAG1; MIP1B; SCYA4; LAG-1; MIP-1-beta; ACT-2

UniProt Entry Name

CCL4_HUMAN

NCBI Protein Information

C-C motif chemokine 4; G-26 T-lymphocyte-secreted protein; MIP-1-beta(1-69); PAT 744; SIS-gamma; T-cell activation protein 2; lymphocyte activation gene 1 protein; macrophage inflammatory protein 1-beta; secreted protein G-26; small inducible cytokine A4 (homologous to mouse Mip-1b)

NCBI Summary for MIP-1 BETA

The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. [provided by RefSeq, Dec 2012]

UniProt Comments for MIP-1 BETA

CCL4: Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5- mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Chemokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: extracellular space; extracellular region

Molecular Function: identical protein binding; CCR1 chemokine receptor binding; protein binding; chemokine activity; cytokine activity; CCR5 chemokine receptor binding

Biological Process: cell-cell signaling; response to virus; response to toxin; establishment and/or maintenance of cell polarity; immune response; positive regulation of calcium-mediated signaling; signal transduction; positive regulation of calcium ion transport; cell adhesion; inflammatory response; cell motility

Research Articles on MIP-1 BETA

1. The allele and genotype frequencies of CCL2, CCL3 and CCL4 were not different between HCs and patients with PTB.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MIP-1 BETA antibody

Reference Product	PubMed Publications
CCL3 antibody	>1619 publications with MIP-1 BETA and CCL3
CCR5 antibody	>593 publications with MIP-1 BETA and CCR5
CCR1 antibody	>198 publications with MIP-1 BETA and CCR1
CXCL2 antibody	>188 publications with MIP-1 BETA and CXCL2
CCR2 antibody	>108 publications with MIP-1 BETA and CCR2
CXCR3 antibody	>76 publications with MIP-1 BETA and CXCR3
CCR3 antibody	>71 publications with MIP-1 BETA and CCR3
CCR7 antibody	>53 publications with MIP-1 BETA and CCR7
CCR8 antibody	>24 publications with MIP-1 BETA and CCR8
IL1B antibody	>15 publications with MIP-1 BETA and IL1B

Pathways associated with anti-MIP-1 BETA antibody

Products by Pathway	Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytosolic DNA-sensing Pathway antibodies	Cytosolic DNA-sensing Pathway Diagram
Cytosolic DNA-sensing Pathway antibodies	Cytosolic DNA-sensing Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram

Diseases associated with anti-MIP-1 BETA antibody

Disease Name	Pubmed Publications
Immune System Diseases Antibodies	>692 publications with MIP-1 BETA and Immune System Diseases
Protein Deficiency Antibodies	>158 publications with MIP-1 BETA and Protein Deficiency
Bone Diseases Antibodies	>107 publications with MIP-1 BETA and Bone Diseases
Hypertension, Portal Antibodies	>90 publications with MIP-1 BETA and Hypertension, Portal
Disease Susceptibility Antibodies	>77 publications with MIP-1 BETA and Disease Susceptibility
Gastrointestinal Diseases Antibodies	>76 publications with MIP-1 BETA and Gastrointestinal Diseases
Eye Diseases Antibodies	>73 publications with MIP-1 BETA and Eye Diseases
Pneumonia Antibodies	>69 publications with MIP-1 BETA and Pneumonia
Ischemia Antibodies	>61 publications with MIP-1 BETA and Ischemia
Diabetes Mellitus Antibodies	>50 publications with MIP-1 BETA and Diabetes Mellitus

Organs/Tissues associated with anti-MIP-1 BETA antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>4372 publications with MIP-1 BETA and Liver
Blood Antibodies	>3269 publications with MIP-1 BETA and Blood
Lung Antibodies	>403 publications with MIP-1 BETA and Lung
Bone Marrow Antibodies	>300 publications with MIP-1 BETA and Bone Marrow
Kidney Antibodies	>285 publications with MIP-1 BETA and Kidney
Intestine Antibodies	>118 publications with MIP-1 BETA and Intestine
Lymph Antibodies	>110 publications with MIP-1 BETA and Lymph
Parathyroid Antibodies	>14 publications with MIP-1 BETA and Parathyroid
Prostate Antibodies	>11 publications with MIP-1 BETA and Prostate
Adrenal Gland Antibodies	>7 publications with MIP-1 BETA and Adrenal Gland