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CD5L Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS221457

MBS221457 detects an epitope within the C-terminal (CT) region of human CD5L, also known as Apoptosis Inhibitor expressed by Macrophages (AIM), and SP alpha. CD5L is a soluble 38kD glycoprotein which is specifically produced by mature macrophages, and has… More details

$670 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD5L, Polyclonal Antibody
Full Product Name
RABBIT ANTI CD5L (C-TERMINAL)
Product Gene Name
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 1.0mg/ml (lot specific)
Specificity
This item detects an epitope within the C-terminal (CT) region of human CD5L, also known as Apoptosis Inhibitor expressed by Macrophages (AIM), and SP alpha. CD5L is a soluble 38kD glycoprotein which is specifically produced by mature macrophages, and has been shown to support their survival and enhance phagocytic function. CD5L expression is upregulated in response to LXR/RXR heterodimer activation.

CD5L has been shown to mediate the survival of macrophages in atherosclerotic plaques.
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Molecular Weight
38,088 Da
OMIM
602592
3D Structure
ModBase 3D Structure for O43866
Perservative Stabilisers
0.02% Sodium Azide
Immunogen
13 amino acid peptide sequence near the carboxy terminus of human CD5L.
Buffer Solution||Phosphate buffered saline
Antiserum Preparation
Antisera to human CD5L were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Target Species
Human
Applications Tested/Suitable for anti-CD5L antibody
Immunohistology Paraffin*, Western Blot (WB)
Application Notes for anti-CD5L antibody
Western Blot: This item detects a band of approximately 38kDa in Raji cell lysates.
Immunohistology - Paraffin: Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
Western Blotting: Minimum Dilution: 0.5; Maximum Dilution: 1.0ug/ml

Testing Data #1 of anti-CD5L antibody

Western blot analysis of whole cell lysates from Raji human Burkitt's lymphoma cells probed with Rabbit anti Human CD5L, also known as AIM (MBS221457) at 0.5(A), 1(B) and 2(C) ug/ml
Rabbit Anti-CD5L Polyclonal Antibody – Cat# MBS221457

Testing Data #2 of anti-CD5L antibody

Formalin fixed, paraffin embedded human lymph node stained with Rabbit anti Human CD5L (MBS221457) following heat mediated antigen retrieval using sodium citrate buffer (pH6.0)
Rabbit Anti-CD5L Polyclonal Antibody, Testing Data #2 – Cat# MBS221457

Other Notes

Small volumes of anti-CD5L antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD5L purchase

MBS221457 is an antibody targeting CD5L. Also known as RABBIT ANTI CD5L (C-TERMINAL). Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CD5L. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
CD5 antigen-like
NCBI Official Synonym Full Names
CD5 molecule-like
NCBI Official Symbol
CD5L
NCBI Official Synonym Symbols
AIM; API6; PRO229; Spalpha; SP-ALPHA
UniProt Protein Name
CD5 antigen-like
UniProt Synonym Protein Names
CT-2; IgM-associated peptide; SP-alpha
Protein Family
UniProt Gene Name
CD5L
UniProt Synonym Gene Names
API6
UniProt Entry Name
CD5L_HUMAN
NCBI Protein Information
CD5 antigen-like; CD5 antigen-like (scavenger receptor cysteine rich family); CT-2; apoptosis inhibitor 6; igM-associated peptide

UniProt Comments for CD5L

CD5L: May play a role in the regulation of the immune system. Seems to play a role as an inhibitor of apoptosis.

Protein type: Secreted; Receptor, misc.; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q23.1

Cellular Component: extracellular space; membrane; extracellular region

Molecular Function: scavenger receptor activity

Biological Process: receptor-mediated endocytosis; apoptosis; cellular defense response
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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