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XEDAR Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS221471

MBS221471 detects human X-linked ectodermal dysplasia receptor (XEDAR), a 33kD type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily. XEDAR is a homologue of the ectodermal dysplasia receptor (EDAR), and binds to an isoform… More details

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Testing Data View PDF
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Product Overview

Product Name
XEDAR, Polyclonal Antibody
Full Product Name
RABBIT ANTI HUMAN XEDAR
Product Gene Name
anti-XEDAR antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 1.0mg/ml (lot specific)
Specificity
This item detects human X-linked ectodermal dysplasia receptor (XEDAR), a 33kD type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily. XEDAR is a homologue of the ectodermal dysplasia receptor (EDAR), and binds to an isoform of ectodysplasin termed EDA-A2. Binding of ectodysplasin to XEDAR results in the induction of apoptosis, and is thought to be involved ectodermal organ development. New evidence suggests XEDAR may also be involved in skeletal muscle development.
Two predominant isoforms of XEDAR exist; XEDAR-s and XEDAR-L, produced by alternative splicing.
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Molecular Weight
32,959 Da
OMIM
300276
3D Structure
ModBase 3D Structure for Q9HAV5
Perservative Stabilisers
0.02% Sodium Azide
Immunogen
Recombinant human XEDAR.
Buffer Solution||Phosphate buffered saline
Antiserum Preparation
Antisera to XEDAR were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Target Species
Human
Applications Tested/Suitable for anti-XEDAR antibody
Western Blot (WB)
Application Notes for anti-XEDAR antibody
Western Blot: This item detects a band of approximately 33kDa in 293 cell lysates.
Western Blotting: Minimum Dilution: 0.5; Maximum Dilution: 2.0ug/ml

Testing Data #1 of anti-XEDAR antibody

Western blot analysis of whole cell lysates from HEH293 human epithelial kidney cells probed with Rabbit anti Human XEDAR (MBS221471) at 0.5(A), 1(B) and 2(C)
Rabbit Anti-XEDAR Polyclonal Antibody – Cat# MBS221471

Testing Data #2 of anti-XEDAR antibody

Immunohistochemical staining of human skin with Rabbit anti Human XEDAR (MBS221471)
Rabbit Anti-XEDAR Polyclonal Antibody, Testing Data #2 – Cat# MBS221471

Other Notes

Small volumes of anti-XEDAR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for XEDAR purchase

MBS221471 is an antibody targeting XEDAR. Also known as RABBIT ANTI HUMAN XEDAR. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for XEDAR. It may not necessarily be applicable to this product.

NCBI GI #
314122209
NCBI GeneID
60401
NCBI Accession #
NP_001186616.1
UniProt Primary Accession #
Q9HAV5
UniProt Secondary Accession #
Q5VYX9; Q5VYY0; Q6UWM2; Q8IZA6
UniProt Related Accession #
Q9HAV5
GenBank Nucleotide #
NM_001199687.2
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 27 isoform 1
NCBI Official Synonym Full Names
ectodysplasin A2 receptor
NCBI Official Symbol
EDA2R
NCBI Official Synonym Symbols
XEDAR; EDAA2R; EDA-A2R; TNFRSF27
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 27
UniProt Synonym Protein Names
X-linked ectodysplasin-A2 receptor; EDA-A2 receptor
UniProt Gene Name
EDA2R
UniProt Synonym Gene Names
TNFRSF27; XEDAR; EDA-A2 receptor
UniProt Entry Name
TNR27_HUMAN
NCBI Protein Information
tumor necrosis factor receptor superfamily member 27; EDA-A2 receptor; X-linked ectodysplasin-A2 receptor; tumor necrosis factor receptor superfamily member XEDAR

NCBI Summary for XEDAR

EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that are encoded by the anhidrotic ectodermal dysplasia (EDA) gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. The protein encoded by this gene specifically binds to EDA-A2 isoform. This protein is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains 3 cysteine-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, May 2011]
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UniProt Comments for XEDAR

EDA2R: Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq12

Cellular Component: integral to plasma membrane; integral to membrane

Molecular Function: protein binding; tumor necrosis factor receptor activity; receptor activity

Biological Process: epidermis development; tumor necrosis factor-mediated signaling pathway; multicellular organismal development; positive regulation of JNK cascade; activation of NF-kappaB transcription factor
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Research Articles on XEDAR

1. To investigate the evolutionary history of the EDA2R/AR intergenic region, we characterized the haplotype structure of 52 of its highly differentiated SNPs. Nearly all human X chromosomes carry one of two modal haplotypes for these 52 SNPs.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-XEDAR antibody

 Reference Product  PubMed Publications
 EDA antibody  >11 publications with XEDAR and EDA
 TRAF6 antibody  >3 publications with XEDAR and TRAF6
 SLC24A5 antibody  >2 publications with XEDAR and SLC24A5
 FADD antibody  >1 publications with XEDAR and FADD
 CASP8 antibody  >1 publications with XEDAR and CASP8
 CYLD antibody  >1 publications with XEDAR and CYLD
 SLC45A2 antibody  >1 publications with XEDAR and SLC45A2
 TP53 antibody  >1 publications with XEDAR and TP53
 TRAF3 antibody  >1 publications with XEDAR and TRAF3

Pathways associated with anti-XEDAR antibody

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram

Diseases associated with anti-XEDAR antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >9 publications with XEDAR and Necrosis
 Gastrointestinal Diseases Antibodies  >2 publications with XEDAR and Gastrointestinal Diseases
 Congenital Abnormalities Antibodies  >2 publications with XEDAR and Congenital Abnormalities
 Breast Neoplasms Antibodies  >2 publications with XEDAR and Breast Neoplasms
 Carcinoma Antibodies  >1 publications with XEDAR and Carcinoma
 Ovarian Neoplasms Antibodies  >1 publications with XEDAR and Ovarian Neoplasms
 Neoplasms, Experimental Antibodies  >1 publications with XEDAR and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >1 publications with XEDAR and Lung Neoplasms

Organs/Tissues associated with anti-XEDAR antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >7 publications with XEDAR and Skin
 Bone Antibodies  >2 publications with XEDAR and Bone
 Brain Antibodies  >2 publications with XEDAR and Brain
 Muscle Antibodies  >1 publications with XEDAR and Muscle
 Lung Antibodies  >1 publications with XEDAR and Lung
 Embryonic Tissue Antibodies  >1 publications with XEDAR and Embryonic Tissue
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