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Lymphotactin (XCL1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS221563

Rabbit anti Human Lymphotactin antibody recognizes human Lymphotactin, otherwise known as XCL1, the only member of the C-chemokine family identified so far. Unlike other members of the chemokine superfamily, Lymphotactin uniquely acts as a chemoattractant for… More details

$740 / 0.1 mg +1 FREE 8GB USB
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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
LYMPHOTACTIN (XCL1), Polyclonal Antibody
Full Product Name
RABBIT ANTI HUMAN LYMPHOTACTIN
Product Gene Name
anti-XCL1 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Form/Format
Purified
Purified IgG - lyophilised
Concentration
IgG concentration 1.0 mg/ml (lot specific)
Preparation and Storage
Prior to reconstitution store at 4 degree C. After reconstitution store at -20 degree C. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of reconstitution
Molecular Weight
12,517 Da
OMIM
600250
3D Structure
ModBase 3D Structure for P47992
Reconstitution
Reconstitute with 0.1 ml distilled water. For long term storage the addition of 0.09% sodium azide is recommended. NB: For functional studies do not use azide.
Immunogen
Recombinant human lymphotactin
Buffer Solution||Phosphate buffered saline
Antiserum Preparation
Antisera to human lymphotactin were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Target Species
Human
Applications Tested/Suitable for anti-XCL1 antibody
ELISA (EIA), Functional Assays (FN), Immunohistology Paraffin*, Western Blot (WB)
Application Notes for anti-XCL1 antibody
ELISA: Minimum Dilution: 0.5; Maximum Dilution: 2.0ug/ml;
Functional Assays: Minimum Dilution: 1.7; Maximum Dilution: 3.0ug/ml;
Immunohistology - Paraffin: Maximum Dilution: 0.5ug/ml; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
Western Blotting: Minimum Dilution: 0.1; Maximum Dilution: 0.2ug/ml

Other Notes

Small volumes of anti-XCL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for XCL1 purchase

MBS221563 is an antibody targeting XCL1. Also known as RABBIT ANTI HUMAN LYMPHOTACTIN. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for XCL1. It may not necessarily be applicable to this product.

NCBI GI #
4506853
NCBI GeneID
6375
NCBI Accession #
NP_002986.1
UniProt Primary Accession #
P47992
UniProt Secondary Accession #
Q52MA8
UniProt Related Accession #
P47992
GenBank Nucleotide #
NM_002995.2
NCBI Official Full Name
lymphotactin
NCBI Official Synonym Full Names
chemokine (C motif) ligand 1
NCBI Official Symbol
XCL1
NCBI Official Synonym Symbols
LTN; ATAC; LPTN; SCM1; SCM-1; SCM1A; SCYC1; SCM-1a
UniProt Protein Name
Lymphotactin
UniProt Synonym Protein Names
ATAC; C motif chemokine 1; Cytokine SCM-1; Lymphotaxin; SCM-1-alpha; Small-inducible cytokine C1; XC chemokine ligand 1
Protein Family
Lymphotactin
UniProt Gene Name
XCL1
UniProt Synonym Gene Names
LTN; SCYC1
UniProt Entry Name
XCL1_HUMAN
NCBI Protein Information
lymphotactin; SCM-1-alpha; XC chemokine ligand 1; c motif chemokine 1; cytokine SCM-1; lymphotaxin; single cysteine motif 1a; small inducible cytokine subfamily C, member 1 (lymphotactin); small-inducible cytokine C1

NCBI Summary for XCL1

This antimicrobial gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1. [provided by RefSeq, Sep 2014]
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UniProt Comments for XCL1

XCL1: Chemotactic activity for lymphocytes but not for monocytes or neutrophils. Belongs to the intercrine gamma family.

Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1q23

Cellular Component: extracellular space; extracellular region

Molecular Function: protein homodimerization activity; chemokine receptor binding; chemokine activity

Biological Process: neutrophil chemotaxis; negative regulation of T-helper 1 type immune response; positive regulation of T cell mediated cytotoxicity; negative regulation of transcription factor activity; response to virus; positive regulation of T cell cytokine production; positive regulation of leukocyte chemotaxis; negative regulation of T cell cytokine production; signal transduction; positive regulation of interleukin-10 production; negative regulation of interleukin-2 production; cell-cell signaling; negative regulation of interferon-gamma production; release of sequestered calcium ion into cytosol; regulation of inflammatory response; immune response; positive regulation of release of sequestered calcium ion into cytosol; negative regulation of transcription, DNA-dependent
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Research Articles on XCL1

1. XCL1 displays antimicrobial activity against E. coli and S. aureus.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-XCL1 antibody

 Reference Product  PubMed Publications
 CD4 antibody  >46 publications with XCL1 and CD4
 XCR1 antibody  >32 publications with XCL1 and XCR1
 CXCR3 antibody  >10 publications with XCL1 and CXCR3
 CCR5 antibody  >8 publications with XCL1 and CCR5
 CCR1 antibody  >5 publications with XCL1 and CCR1
 CX3CR1 antibody  >4 publications with XCL1 and CX3CR1
 CCR7 antibody  >3 publications with XCL1 and CCR7
 CCR2 antibody  >3 publications with XCL1 and CCR2
 CCR3 antibody  >2 publications with XCL1 and CCR3

Pathways associated with anti-XCL1 antibody

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram

Diseases associated with anti-XCL1 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >27 publications with XCL1 and Inflammation
 Necrosis Antibodies  >17 publications with XCL1 and Necrosis
 Disease Models, Animal Antibodies  >16 publications with XCL1 and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >14 publications with XCL1 and Neoplasms, Experimental
 Lung Diseases Antibodies  >12 publications with XCL1 and Lung Diseases
 Nervous System Diseases Antibodies  >6 publications with XCL1 and Nervous System Diseases
 Colonic Neoplasms Antibodies  >4 publications with XCL1 and Colonic Neoplasms
 Eye Diseases Antibodies  >4 publications with XCL1 and Eye Diseases
 Kidney Diseases Antibodies  >3 publications with XCL1 and Kidney Diseases
 Pain Antibodies  >3 publications with XCL1 and Pain

Organs/Tissues associated with anti-XCL1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >138 publications with XCL1 and Blood
 Lung Antibodies  >16 publications with XCL1 and Lung
 Lymph Node Antibodies  >8 publications with XCL1 and Lymph Node
 Kidney Antibodies  >7 publications with XCL1 and Kidney
 Prostate Antibodies  >2 publications with XCL1 and Prostate
 Uterus Antibodies  >1 publications with XCL1 and Uterus
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