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CD186 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS221620

MBS221620 recognises the orphan G protein-coupled chemokine receptor CXCR6, also known as CDw186. CXCR6 has been identified as a co-receptor for simian immunodeficiency virus (SIV), HIV-2 and HIV-1. Lymphoid tissues and activated peripheral blood lymphocytes… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
CD186, Polyclonal Antibody
Full Product Name
RABBIT ANTI HUMAN CD186
Product Gene Name
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 0.5 mg/ml (lot specific)
Specificity
This item recognises the orphan G protein-coupled chemokine receptor CXCR6, also known as CDw186. CXCR6 has been identified as a co-receptor for simian immunodeficiency virus (SIV), HIV-2 and HIV-1. Lymphoid tissues and activated peripheral blood lymphocytes express CXCR6 mRNA.
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Molecular Weight
39,280 Da
OMIM
605163
3D Structure
ModBase 3D Structure for O00574
Perservative Stabilisers
0.02% Sodium Azide
Immunogen
Peptide corresponding to amino acids 11 to 25 of human CXCR6/CDw186 (NT).
Buffer Solution||Phosphate buffered saline
Antiserum Preparation
Antisera to CDw186 (NT) were raised by repeated immunisation of rabbit with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Target Species
Human
Applications Tested/Suitable for anti-CD186 antibody
Western Blot (WB)
Application Notes for anti-CD186 antibody
Western Blotting: Maximum Dilution: 1/500

Testing Data #1 of anti-CD186 antibody

Western blot analysis of CDw186 (also known as CXCR6/Bonzo) in human spleen tissue lysate in the absence (lane A) or presence (lane B) of peptide with MBS221620
Rabbit Anti-CD186 Polyclonal Antibody – Cat# MBS221620

Testing Data #2 of anti-CD186 antibody

Immunocytochemical staining of human spleen with Rabbit anti Human CD186, also known as BONZO (MBS221620)
Rabbit Anti-CD186 Polyclonal Antibody, Testing Data #2 – Cat# MBS221620

Other Notes

Small volumes of anti-CD186 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD186 purchase

MBS221620 is an antibody targeting CD186. Also known as RABBIT ANTI HUMAN CD186. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CD186. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
C-X-C chemokine receptor type 6
NCBI Official Synonym Full Names
chemokine (C-X-C motif) receptor 6
NCBI Official Symbol
CXCR6
NCBI Official Synonym Symbols
BONZO; CD186; STRL33; TYMSTR
UniProt Protein Name
C-X-C chemokine receptor type 6
UniProt Synonym Protein Names
CDw186; G-protein coupled receptor STRL33; G-protein coupled receptor bonzo; CD_antigen: CD186
UniProt Gene Name
CXCR6
UniProt Synonym Gene Names
BONZO; STRL33; TYMSTR; CXC-R6; CXCR-6
UniProt Entry Name
CXCR6_HUMAN
NCBI Protein Information
C-X-C chemokine receptor type 6; CDw186; CXC-R6; CXCR-6; G protein-coupled receptor; G-protein coupled receptor STRL33; G-protein coupled receptor bonzo

UniProt Comments for CD186

CXCR6: Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1

Chromosomal Location of Human Ortholog: 3p21

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; coreceptor activity; C-X-C chemokine receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; viral genome replication; chemotaxis; inflammatory response
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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