Calcitonin Receptor (CTR) Antibody – Rabbit

CALCR: This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. Belongs to the G-protein coupled receptor 2 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 4q13

Cellular Component: acrosomal vesicle; axon; cell soma; cilium; integral component of membrane; neuron projection; plasma membrane

Molecular Function: calcitonin binding; calcitonin receptor activity; protein transporter activity; receptor activity

Biological Process: activation of phospholipase C activity; adenylate cyclase activation; adenylate cyclase-activating G-protein coupled receptor signaling pathway; cell surface receptor signaling pathway; elevation of cytosolic calcium ion concentration; G-protein coupled receptor signaling pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; negative regulation of ossification; osteoclast differentiation; positive regulation of adenylate cyclase activity; positive regulation of cAMP biosynthetic process; positive regulation of cAMP metabolic process; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein kinase B signaling; protein transport; receptor internalization; regulation of bone resorption; regulation of mRNA stability; response to glucocorticoid stimulus